Simon J. Clark

Study of 156 dengue patients shows distinct complement signatures by disease severity, with soluble CR1 emerging as an independent early predictor of severe outcomes. #Dengue #Immunology #ComplementSystem #Biomarkers #GlobalHealth #Science buff.ly/da4fIQb

New study links gut microbiome function, not composition, to complement dysregulation and genetic risk in geographic atrophy, highlighting a systemic gut/immune/retina axis. #GeographicAtrophy #AMD #Microbiome #Genomics #Ophthalmology #Science buff.ly/7yU87jB

This is fantastic news from Complement Therapeutics! MHRA CTA approval for CTx001, which will lead to an expansion of the clinical trials into both the US and UK. #FDA #MHRA #clinicaltrials #AMD #IND #compelment #ophthalmology buff.ly/Fx8SF4O

New genetic evidence links higher bone mineral density to a lower risk of wet age-related macular degeneration, reframing AMD as a systemic ageing disease, not just an eye disorder. #AMD #VisionResearch #Ageing #Ophthalmology #BoneHealth #Genetics #Science buff.ly/7n1UsRh

New study shows deleting FHR1 reduces atherosclerosis, inflammation, and plaque formation in mice—revealing a novel immune-lipid axis in cardiovascular disease. #Atherosclerosis #CardioScience #Immunology #ComplementSystem #TranslationalResearch buff.ly/QEVu3ct

New evidence suggests the retina may reveal Alzheimer’s disease before dementia, with OCT/OCT-A detecting early structural and vascular changes—even preclinically. #Alzheimers #Neurodegeneration #OCT #Biomarkers #EarlyDetection #Neuroscience buff.ly/LLd7n8T

New study shows ring aperture Retro mode imaging detects pigment migration in AMD with high sensitivity—matching en face OCT and outperforming standard fundus imaging. #AMD #RetinalImaging #Ophthalmology #MedicalImaging #Diagnostics #VisionScience buff.ly/IiLyyjg

New study shows combining microperimetry with AI-quantified OCT biomarkers captures localized functional loss in geographic atrophy—pointing to more sensitive clinical trial endpoints. #GeographicAtrophy #AMD #Ophthalmology #AIinMedicine #ClinicalTrials buff.ly/DuHs30i

Prelim Phase 2 data hint Ocugen’s AAV5 gene therapy (OCU410) may outperform approved GA treatments at mid-dose, while higher doses raise intriguing biology questions 👀🧬 #GeneTherapy #DryAMD #GeographicAtrophy #Biotech #ClinicalTrials buff.ly/KBGv9y2

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New Cell Reports study moves GWAS from association to causation, using single-cell multiomics to pinpoint causal variants driving macular degeneration. #Genomics #GWAS #CausalVariants #PrecisionMed #AMD #complement buff.ly/w7b7CPU

Scientific Reports links systemic complement activation to choroidal thinning in advanced non-neovascular AMD, pointing to immune-driven disease #AMD #Ophthalmology #Immunology #BiomedicalResearch #Science buff.ly/1w46ZAn

A life-changing breakthrough in eye care: a pioneering injection has restored sight and prevented blindness—showing how medical innovation can truly change lives. 👁️✨ #MedicalBreakthrough #EyeHealth #HealthcareInnovation #ScienceForGood #PatientImpact buff.ly/uMgzlvG

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@ProfClark Please what we are seeing.

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Large-scale pan-cancer analysis identifies Complement Factor H (CFH) as a novel immune-related and prognostic biomarker, linking complement regulation to tumor immunity and patient outcomes. #CancerResearch #ImmunoOncology #Biomarkers #PrecisionMedicine buff.ly/XmlgOQB

TME Pharma is rethinking its eye drug strategy after losing a key partner, shifting focus to preclinical validation of its novel anti-fibrotic approach in ophthalmology. #Biotech #Ophthalmology #DrugDevelopment #PharmaNews buff.ly/u5X3P5L

Great 2026 news for ocular gene therapy: Ikarovec partners with VectorBuilder to attempt intravitreal delivery of IKAR-003. Nice to see continuing innovation in this challenging space. #GeneTherapy #Ophthalmology #AAV buff.ly/8Ich46b

A global first in AMD research: the RIMR AMD Consortium unites 100k+ longitudinal OCT scans across continents, unlocking scalable AI-ready insights into disease progression. #AMD #Retina #Ophthalmology #OCT #AIinHealthcare #BigData #VisionScience #MedTech buff.ly/qQNCKQ5

An opportunity for someone to join our team! We're looking for a 50% Technical Assistant from Feb. 2026 - Dec. 2030 Application deadline 15th Jan 2026! Please see