Our lab just published a JoVE video article covering PDX models for paediatric brain cancer. Here’s a quick preview!
Link to full video and article: hubs.ly/Q042_QJ40
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Prof David Ziegler
377 posts
Prof David Ziegler
@ProfDavidZieg
Paediatric oncologist, clinical trials, neuro-oncology, precision medicine.
Sydney เข้าร่วม Aralık 2019
334 กำลังติดตาม799 ผู้ติดตาม
Prof David Ziegler รีทวีตแล้ว
📰 Discover the special issue of #Daily27 for #ChildhoodCancerDay
Read insights from international experts in our two new articles on #childhoodcancerawareness and new advances in the fight against pediatric brain tumors 💛 #EndChildhoodCancer #Oncology #Health #News 👇🧵
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Thanks to 27 Daily for allowing me to share some thoughts on World Childhood Cancer Day
Daily 27@Daily27Info
🧵'A New Chapter in the Fight Against Childhood Brain Cancer' 🌍 #InternationalChildhoodCancerDay ✍️ David Ziegler, paediatric oncologist at the @KidsCancerInst 🔗 daily27.info/2026/02/15/a-n… #EndChildhoodCancer #BrainCancer #Health #News
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Very excited about this paper - new way to shut down transcription in DMG - looking now at clinical translation
Science Translational Medicine@ScienceTM
Inhibitors of the proteins FACT and BET disrupt transcription in #DiffuseMidlineGlioma and extend survival in mice, hinting this combo can suppress hard-to-target epigenetic drivers of this pediatric cancer. @holly_holliday_ @ProfDavidZieg @KidsCancerInst scim.ag/3ZfoysL
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Congrats to the team for our work - on the cover of Science Translational Medicine! One more step forward to find effective treatments for #DIPG. Thanks to all our funders - See details here:
Holly Holliday@holly_holliday_
New in @ScienceTM 🧬 On the cover! Our work on diffuse midline glioma (#DMG #DIPG), an incurable paediatric brain cancer driven by epigenetic changes. We asked: Can targeting chromatin slow tumour growth?🔗science.org/doi/10.1126/sc… #ScienceTranslationalMedicineResearch
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Prof David Ziegler รีทวีตแล้ว
New in @ScienceTM 🧬 On the cover!
Our work on diffuse midline glioma (#DMG #DIPG), an incurable paediatric brain cancer driven by epigenetic changes. We asked: Can targeting chromatin slow tumour growth?🔗science.org/doi/10.1126/sc…
#ScienceTranslationalMedicineResearch
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Prof David Ziegler รีทวีตแล้ว
Together, these results support dual FACT + BET inhibition as a promising DMG therapy, hitting both tumour-intrinsic vulnerabilities and immune defenses.
@KidsCancerInst @UNSW
Huge thanks to @aaminahkhan_1, @ProfDavidZieg, @maria_tsoli & all collaborators!
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Prof David Ziegler รีทวีตแล้ว
@KidsCancerInst @UNSW @aaminahkhan_1 @ProfDavidZieg @maria_tsoli This work was generously supported by grants from @nhmrc, @cancerNSW, @DIPGCollab, @CureStartsNowAU, @KidsCancerProj, @thekca, We Love You Connie Foundation and Levi’s project
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Prof David Ziegler รีทวีตแล้ว
Listen to Oprah! Time to book your trip to Australia. #ISPNO2026
instagram.com/reel/DRw5SJ1gG…
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Prof David Ziegler รีทวีตแล้ว
Registration and abstract submissions now open for ISPNO 2026! ispno2026.org
The world's entire paediatric brain tumour community will be heading Down Under in 2026 - don't miss out!
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Prof David Ziegler รีทวีตแล้ว
Join us in Sydney for ISPNO 2026! Experience one of the world’s most vibrant cities, where golden beaches, iconic landmarks & rich First Nations culture await. 🌊🌿
📍 Watch: vimeo.com/1126715713
Registrations open: ispno2026.org
#ISPNO2026 #Sydney #SeeAustralia
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You might even get a free koala 🐨
ISPNO2026@ISPNO2026
ISPNO 2026 now just over a year away! We will be attending PedSNO - come visit for a chance at complimentary registration!!
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Prof David Ziegler รีทวีตแล้ว
Great work from the team and hopefully a helpful resource for many @ JoVE app.jove.com/t/67349
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Prof David Ziegler รีทวีตแล้ว
@OdedRechavi I tend to agree but I didn’t see this post so can’t reply
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I'm not basing this on data, just a hunch, but I think that while many academics obviously left Twitter (call it X if you want to, i won't), and people use it less often, I believe most (>70%?) are still here and just don't see each other's posts because the algorithm is broken.
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Prof David Ziegler รีทวีตแล้ว
Excited to see our work published in Neuro-Oncology @NeuroOnc. Large international study of 252 patients with #DMG #DIPG with paired #germline #somatic. One patient had a near-complete response to PARP+immune checkpoint inhibition. pubmed.ncbi.nlm.nih.gov/40072012/
@ProfDavidZieg
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Thanks to all collaborators who helped assemble the largest cohort of DMG patients with germline sequencing. Helping us understand the cause and new DMG treatments:
Germline analysis of an international cohort of pediatric diffuse midline glioma patients academic.oup.com/neuro-oncology…
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12: Thanks to funding from NHMRC, CINSW, Cancer Australia, Cure Brain Cancer, The DIPG Collaborative, The Cure Starts Now, Levi's Project, Benny Wills Fund.
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11: Thanks to all the patients and families who have supported this work through advice, encouragement, fund raising and allowing us to use their child's tumour samples - without which no research is possible
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3: Despite including hundreds of anti-cancer drugs, most of them were completely inactive against DIPG cells - however a small number - 90 - were highly potent
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