Hesper Rego

Faculty Search Webinar! Curious about the @YaleMicroPath faculty search and life in CT? Please join us for a Q&A webinar 9/19/24 12pm noon EST. Panelists @Rego_Lab, @HoLabHIV, @Goodman_lab, and Craig Roy. Participation is anonymous. Registration required: yale.zoom.us/webinar/regist…

Faculty search! @YaleMicroPath is looking to hire assistant professor(s) focused on the pathogenesis of viral, bacterial, parasitic, or fungal infections. Info: apply.interfolio.com/151755. Q&A webinar in Sept. Please RT!

@javid_lab Thank you, @javid_lab! Colleague = @jesssherica6, postdoc extraordinaire and fellow UCSF alum. Expect to see more from her in the future.

Lovely and comprehensive review on bacterial phenotypic heterogeneity from @Rego_Lab and colleague. Phenotypic Heterogeneity in Pathogens annualreviews.org/content/journa…

MmpL3, Wag31 and PlrA are involved in coordinating polar growth with peptidoglycan metabolism and nutrient availability biorxiv.org/cgi/content/sh… #biorxiv_micrbio

@FreundlichGroup Thank you!

Congratulations! We look forward to reading it.

Another paper from the lab. The now Dr. Ng, @weilynnng , describes how the nucleoid associated protein, Lsr2, helps promote chromosomal mutagenesis in mycobacteria. journals.asm.org/doi/full/10.11…

@javid_lab @lttlAFM Congratulations Babak and Alex et al!! Very cool work.

Can bacterial *mechanical properties* affect virulence? YES! Excited this is finally out, led by @lttlAFM . "Soft" mycobacteria survive better within macrophages! Mechanical morphotype switching as an adaptive response in mycobacteria | Science Advances science.org/doi/10.1126/sc…

@HeranDarwin Awesome!!!

Lots of cool imaging went into this work (time-lapse 3D-SIM, biosensors, etc). It wouldn't have been possible without the efforts of Lin Shao @shaomumu who built our microscope, and made our analysis methods more robust and scalable.

This led to several surprising insights about the metabolism of mycobacteria at the single cell level. Specifically we show that the complexes that perform OXPHOS are spatially segregated from those that grow the bacterium. And metabolism changes as individual mycobacteria age.

Really excited about this work from the lab. @celenagwin, together with @Kuldeep_R_Gupta, worked to understand how mycobacteria create heterogeneity in growth. biorxiv.org/content/10.110…

Curious about the @YaleMicroPath faculty search? Please join on 9/18/23 at 12 noon EST for a Q&A webinar with @HoLabHIV @Rego_Lab @wmothes @Goodman_lab. Attendance and questions are anonymous. Details on department website. Register here: yale.zoom.us/webinar/regist…. Please RT!

@HarvardMITmdphd @DanielHFRubin @yhgrad @BBS_Harvard Go Dan!!!

We are thrilled to share news of @HarvardMITmdphd student @DanielHFRubin’s successful thesis defense entitled, “Mechanisms and acquisition of antibiotic resistance in N. gonorrhoeae.” Shout out to @yhgrad and Matthew Waldor for their outstanding mentorship! @BBS_Harvard

@RaphaelPark7 Go, Raphael and team!!

First Park lab group photo! 📸📸📸

@javid_lab Agreed!

@Rego_Lab kind of you Hesper and feeling is very mutual! It's been too long since we've caught up!

Awesome opportunity to work with a great person!

@chaaawie @NatureMicrobiol Congratulations, Charlie and team! A beautiful story showcasing the power of live cell imaging. 😀

To learn about phage infection and resistance in mycobacteria, we isolated resistant mutants and used microscopy to visualize the entire lytic lifecycle within single cells and in populations. Check out the video highlights below! @NatureMicrobiol nature.com/articles/s4156…

@SkyeFishbein7 Thanks, Skye!

Really excited and proud of this work out of our lab. elifesciences.org/articles/80395.

Studying a protein of unknown function is not for the faint of heart. We had many misdirections along the way, and there is still much to discover. Most importantly, we had loads of help from amazing collaborators: @ymoritalab, @JunLiuLab, and Ben Swarts' lab at CMU.

@Kuldeep_R_Gupta, working together with @celenagwin, discovered that a protein of unknown function in mycobacteria (PgfA) is recruited to one side of the cell by our favorite protein LamA, where it coordinates lipid trafficking and fast polar growth