Wickens Group

Finally, the mystery is solved 🕵️ We now know why allylic functionalization of alkenes via thianthrenation is Z-selective! In collaboration with the Gutierrez group, we uncovered a rare example of stereoselective deprotonation. Now at JACS! tinyurl.com/t4rkkru3

Elucidating the Mechanism of Electrooxidative Allene Dioxygenation: Dual Role of Tetramethylpiperidine N-Oxyl (TEMPO) | JACS @UWMadisonChem @UWMadison @JenniferSchoma4 @unipv @TotalSyntheses #Mechanism #Electrooxidative #Allene #Dioxygenation #TEMPO pubs.acs.org/doi/10.1021/ja…

Alkene Carboxy-Alkylation via CO2•– | Journal of the American Chemical Society @ZachWickens @WickensGroup @UWMadisonChem @UWMadison @TotalSyntheses #Alkene #CarboxyAlkylation #CO2RadicalAnion pubs.acs.org/doi/10.1021/ja…

As part of our ongoing collaboration with @Charles_chem at Merck, we found a new way to promote alkene carboxy-alkylation that exploits the unique chemoselectivity profile of CO2•- accessed from formate! Check it out: pubs.acs.org/doi/full/10.10… Congrats to all the authors!!

Congratulations Karina, @AchyutRanjanGo1, @angellegnarent1, and @minjik1997!

Finally, the mystery is solved 🕵️ We now know why allylic functionalization of alkenes via thianthrenation is Z-selective! In collaboration with the Gutierrez group, we uncovered a rare example of stereoselective deprotonation. Now at JACS! tinyurl.com/t4rkkru3

The #WickensPOM for April is the Hu group’s azo-free Mitsunobu reaction! Check out their clever use of paired electrolysis to overcome the pKa limitation of nucleophiles in Mitsunobu! tinyurl.com/28s2ea5t

The #WickensPOM for March is the Liu group’s aminative Suzuki-Miyaura reaction involving a formal nitrene insertion. We’re excited to see how this inspires other transition metal chemistry and for future work from the Liu group! tinyurl.com/4pu3vux6

@SongLinLab this is our superbowl

🥁🥁🥁Wickens Paper of the Year drop 🥁🥁🥁 we loved this work from the @SongLinLab showing tunable frustrated radical pairs for regioselective C–H functionalization! bit.ly/49iYa4J

Alkene Thianthrenation Unlocks Diverse Cation Synthons: Recent Progress and New Opportunities (Zachary K. Wickens and co-workers) @WickensGroup @ZachWickens @minjik1997 @De_holst @dj_wang_ #AngewandteReview #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

congratulations @minjik1997, Karina, @De_holst, and @dj_wang_!

Check out our group’s first review article-- a minireview describing how you can get to diverse cation synthons using alkene thianthrenation electrophiles! It’s been amazing to see the progress in this area! bit.ly/3usdcGc

In the latest #WickensPOM, the @MacMillan_Lab developed an undirected alkene dialkylation strategy with perfect regioselectivity by controlling the reactivity of three transient radicals! tinyurl.com/4an4tspj

It’s here! It’s here! Check out the latest episode of the pod featuring @Charles_chem, @MyriaMikhael and @ZachWickens highlighting a great collaboration with the @WickensGroup! #MerckChemistry Show page: anchor.fm/pharm-to-table

In the latest #WickensPOM, the McCusker group and @MacMillan_Lab show Marcus inverted excited state lifetimes and novel photoreactivity for cobalt complexes. We’re excited to see where this paper takes the field of photoredox catalysis in the future! science.org/doi/10.1126/sc…

In the latest #WickensPOM, the @GilmourLab use chiral Al salen complexes with light as a novel mode for deracemization of cyclopropyl ketones. Excited to see what else these systems may accomplish in the future! bit.ly/3F7fXhQ

Congratulations to the team @thechestersang, @SaraAlektiar, @nickcowper, and @jennifer_sowin!

Check out our latest work @J_A_C_S leveraging electrophotocatalysis to access ketyl radicals! We found polycyclic aromatic hydrocarbons are a uniquely competent class of catalysts, which enabled our group's first non-fragmentation based reduction strategy bit.ly/48j9E8v

In the latest #WickensPOM, the @GouverneurGroup developed a direct activation of fluorspar CaF2 via ball milling to access a safe and stable nucleophilic fluorinating reagent that bypasses HF-derived reagents in the synthesis of fluorinated compounds bit.ly/3OWNMXo

Great talks by @HwangGroup , @jjoolab , @kwangminshin , Asst. Prof. Jang & Profs. Hong, Cho & You. Even if I heard their talks before; the science of @WickensGroup & @Hyunwoo__Kim never ceases to amaze!