Ashita Debnath, PharmD, BCIDP

EMBLAVEO: catchy name & innovative antibiotic Enterobacterales-MBL-AVibactam-aztrEOnam Aztreonam/avibactam is being developed on the rationale that ⚡️Aztreonam isn't hydrolyzed by MBL enzymes ⚡️Avibactam takes care of serine β-lactamases, eg ESBL/AmpC , co-produced by MBL

The removal of #HIV- and #LGBTQ-related resources from the websites of the @CDCgov and other health agencies is deeply concerning. Access to this information is crucial for ID and HIV health care professionals. Our full statement: bit.ly/3PYun9v

📰 Extra! Extra! Read all about the 2024 updates to the IDSA Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections. Below are highlights from the Notable Updates from 2023 section. For more info: buff.ly/3WdrVyr #AntimicrobialResistance #IDTwitter

The largest study of Pseudomonas endocarditis to date 🆕️🔥#JAC @Shahnanigans1 @ryankshields Clinical manifestations and treatment outcomes for patients with Pseudomonas endocarditis Combination therapy did not improve clinical outcomes #IDXposts #IEwiki academic.oup.com/jac/article-ab…

Is anaerobic coverage necessary for aspiration pneumonia with metronidazole or Augmentin? NEJM JWatch reports from a large retro study with N ~ 4000 Findings show no added mortality benefit but an increased risk of CDI journal.chestnet.org/article/S0012-… #IDTwitter #IDXposts

🔥 Just published 🔥 @IDSAInfo 2024 Guideline Update on the Risk Assessment, Diagnostic Imaging, and Microbiological Evaluation of Complicated Intra-abdominal Infections in Adults, Children, and Pregnant People #idxposts #Recommendation:BloodCulturesforKnownorSuspectedIntra-abdominalInfectionAdultsandChildren" target="_blank" rel="nofollow noopener">idsociety.org/practice-guide…

🆕️⚡️#JAC Clinical outcomes in patients infected with ertapenem only resistant Enterobacterales versus multi-carbapenem-resistant Enterobacterales #IDXposts #CRE academic.oup.com/jac/article-ab…

💥BLING III RCT ➡️Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis ⭐The observed difference in 90-day mortality did not meet statistical significance in the primary analysis. ⭐A clinically important benefit with CI is possible.

This #IDPharmacistsDay remember the "5 Ways Pharmacists can Be Antibiotics Aware!" Visit sidp.org/AMSToolkit to access information on ways to contribute to #AntimicrobialStewardship. @SIDPharm

🔥ORACLE🔥 @yourICM @TrubianoJason A Pilot RCT of Direct Oral Challenge(DOC) vs Routine Care in Low-Risk Penicillin Allergy in Critical Illnes This study supports the safety & efficacy of DOC in low-risk[PEN -FAST< 3] penicillin allergy in ICU #IDXposts link.springer.com/article/10.100…

🔥DOTS🔥 The most anticipated RCT #ESCMIDGLOBAL2024 Dalbavancin is non-inferior to SOC by clinical efficacy for complicated SAB incl Rt sided IE 2 doses Dalba 1500 mg on days 1 & 8 or 4-8 wks of SOC(cefaz or naf:MSSA;vanc or dapto:MRSA) DOOR at D70 Slides shared by @LordAlirezaF

pubmed.ncbi.nlm.nih.gov/31527026/ #IDTwitter any experience using ertapenem thrice weekly after hemodialysis to treat ESBL enterobacterales infection for instance a Klebsiella Osteomyelitis? @BradSpellberg @DrToddLee @ABsteward @wwrighID @dralicehan @mmPharmD @JGPharmD @CynthiaNixon

Everyone who's treating MRSA Bacteremia should read this article now! An excellent review by @VanceFowler5 et Al @CIDJournal Persistent MRSA Bacteremia: Resetting the Clock for Optimal Management 🌟Excellent figures 🌟 @snap_trial Thoughts 🤔 #IDTwitter academic.oup.com/cid/article-ab…

@voRIC0nazole @IDSAInfo Congrats!!!

Stewardship is H A R D. While this designation doesn’t really change my day to day practice - the “thank yous” and positive comments from providers seeing this designation has given me a little nudge after a tough few months for me personally/professionally #IDTwitter

In case you missed it--this one's big!!🔥🔥 in @JAMAInternalMed we found inappropriate diagnosis of #pneumonia to be common and abx treatment harmful. Similar parallels to ASB--> highest risk in older adults with dementia & altered mental status. jamanetwork.com/journals/jamai…

🆕️🔥 #AJG A non-inferiority trial comparing 2 days vs. 5 days of terlipressin and ceftriaxone in terms of 5-day rebleeding for patients with acute gastro-esophageal variceal hemorrhage #IDXposts @BradSpellberg #Shorterisbetter? journals.lww.com/ajg/abstract/9…

@DevinPharmID @W_DePasquale Congrats on the pub!! It was awesome to work with you on it ☺️

Honored 😎 @ashinetobacter @W_DePasquale

🆕️⚡️ @AJHPOfficial Cost evaluation of continuation of therapy with dalbavancin compared to standard-of-care antibiotics alone in hospitalized persons who inject drugs with severe gram-positive infections #IDXposts #PWID academic.oup.com/ajhp/advance-a…

🆕️🔥 Systematic Review and Meta-Analysis @OFIDJournal Investigating Non-Penicillin Therapeutic Strategies in Syphilis Treatment Penicillin monotherapy did not outperform ceftriaxone, azithromycin, or doxycycline. #IDXposts academic.oup.com/ofid/article/d…

Almost messaged someone saying I’m a pharmacyst… Happy Monday