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The new series at Fire In A Bottle has begun!!
This is my attempt at tying together the threads. PUFA, oxygen, the Cambrian explosion, antioxidants. Copepods. Starting in my back yard.
fireinabottle.net/the-whistle-pi…
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FireInABottle
8.5K posts
FireInABottle
@fire_bottle
Thinks about biology
Trumansburg, NY เข้าร่วม Kasım 2019
590 กำลังติดตาม12K ผู้ติดตาม
@exfatloss Right. Could be some clues there.
I wonder what happens if you fill out the contact form? Probably nothing.
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Wait, what is USredoxLabs.com?! Anybody hear of this?
FireInABottle@fire_bottle
This seems as good a place as any to plug Usredoxlabs.com
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@KetoCarnivore @Leo_Abstract @TuckerGoodrich @sudas1891 @exfatloss @MeTheAngryCat @603_4me @siobhan_huggins Regardless of where one stands on deep evolutionary philosophy, PPARa metabolism and circadian rhythm are co-regulated….
journals.sagepub.com/doi/full/10.41…
nature.com/articles/s4136…
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@Leo_Abstract @TuckerGoodrich @sudas1891 @exfatloss @MeTheAngryCat @603_4me @siobhan_huggins @fire_bottle I see. I would agree with the plausibility of more flexible endothermy in mammalian ancestry.
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@TuckerGoodrich @Leo_Abstract @exfatloss @MeTheAngryCat @siobhan_huggins How about you state your hypothesis before we find out?
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@KetoCarnivore @exfatloss @TuckerGoodrich @sudas1891 @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins I should have said: clofibrate is a pharmaceutical that activates D6D. I really should have responded to this post instead:
L. Amber O'Hearn@KetoCarnivore
@sudas1891 @TuckerGoodrich @exfatloss @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins @fire_bottle Well, Volek and Phinney did report lower D6D in KD mice, despite membrane levels of HUFAs increasing in them (and in KD humans). OTOH PPAR-α (a signature of KD) increases D6D, and KD increases blood levels of DHA and ARA. (Slide from my RDA talk)
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@KetoCarnivore @exfatloss @TuckerGoodrich @sudas1891 @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins The other major factor is PLA2. PLA2 releases the ARA from the SN-2 position of the phospholipids. It is normal to see high conversion to ARA via D6D/D5D but low membrane levels because the ARA is being released and converted to oxylipins.
sciencedirect.com/science/articl…
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@TuckerGoodrich @sudas1891 @exfatloss @KetoCarnivore @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins D6D is controlled by PPARa and is increased by PPARa agonists. So diets high in oleic acid (via OEA) and ALA give the highest D6D activity, although oxidized n6 PUFA ultimately contribute to the positive feedback loop.
mdpi-res.com/d_attachment/n…
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@sudas1891 @exfatloss @KetoCarnivore @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins @fire_bottle But let's gat cause and effect right here. The upregulation wouldn't happen without higher LA levels.
Yes, perhaps you have some protection from some pathways if you have a different FADS genome, but you're not protected from all the pathways.
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@KetoCarnivore @exfatloss @TuckerGoodrich @sudas1891 @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins Remember that D6D and D5D are right next to each other in tight linkage dysequilibrium.
So if you get the HI active D6D, you get the LO D5D (genetically). These people have higher DGLA: LA is rapidly converted to DGLA but the DGLA is slowly converted to AA by D5D.
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@exfatloss @TuckerGoodrich @sudas1891 @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins @fire_bottle No, DGLA. Which suggests that D5D is increased, even if D6D is decreased. So maybe D6D isn't even the important bottleneck.
Weirdly, ketone bodies themselves seem to get used for elongation.
pmc.ncbi.nlm.nih.gov/articles/PMC11…
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@TuckerGoodrich @sudas1891 @Leo_Abstract @exfatloss @KetoCarnivore @MeTheAngryCat @603_4me @siobhan_huggins This is actually the idea. Torpor = increased D6D and SCD1.
PUFA goes down and MUFA goes up.
I don’t see how this connects to oxidative risk. Body temp drops to near freezing, oxygen levels are controlled/low. Not much oxidative risk.
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@sudas1891 @Leo_Abstract @exfatloss @KetoCarnivore @MeTheAngryCat @603_4me @siobhan_huggins @fire_bottle His idea about torpor is wrong, unfortunately.
Mammals that live in tropical areas that hibernate actually lower PUFA, as you would expect from the oxidative risk.
Including the one primate.
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@fire_bottle @kattakastali @dPeeri @siobhan_huggins @trikomes If I just mail you food items and you send me a bunch of numbers and I publish those numbers, hardly your fault is it? Similar to me publishing my OmegaQuant results.
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Lady eats sardines with "olive oil" (🤣), halves ketones
🐄🐷P L U C C🐷 🐄@siobhan_huggins
3 days into 'sardine only' (with olive oil) + B1 and ketones went from 2-3 mmol/L in the mornings to 1-1.6 mmol/L I don't know man.
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@fire_bottle @kattakastali @dPeeri @siobhan_huggins @trikomes Soon! Can't wait haha. Can we just make a public DB of test results for random commercial products, or is that somehow legally risky?
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@exfatloss @kattakastali @dPeeri @siobhan_huggins @trikomes I’m probably 2-3 months out. Coming soon.
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@kattakastali @dPeeri @siobhan_huggins @trikomes interesting. Seems these people are basically claiming that the 2010 UC Davis study on olive oil is fraudulent and sponsored by Californian olive oil producers.
We need an independent lab to test these things. Why is that so hard? @fire_bottle
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Amazing!!
The next generation.
L. Amber O'Hearn@KetoCarnivore
Hard core! We've got ROS theory of obesity representation at @realCSF ! So happy to see someone go through this particular learning qpathway @2ketodudes @DrEades @Peter_InNorfolk BTW the final of this slide included @fire_bottle but I missed that shot.
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@HandyGingerGal @Corbienest It’s not a dude.
But it’s very dark.
Where does the negativity come from? Her or him?
It’s unclear.
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I try to be as unpleasant and difficult to converse with as possible rather than enjoying the company of the man I agreed to go to dinner with 🥴
Dr. Jebra Faushay@JebraFaushay
This woman has a set of rules for ALL of the men in her life. This includes not driving to meet a man and not paying for anything, ever.
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@KetoCarnivore @caloriesproper2 Not that I’m trying to suggest that CICO is important or real. I actually don’t think it’s relevant.
I believe that resistance to electron flow determines everything.
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Ballsy, I guess. I'm sure clinical experience does bring home what works and what doesn't in the practical world. MDs may have more exposure to falsification of theories. But it's not a full protection.
One of his talks that I've seen goes through a set of head-smacking ways his patients have misunderstood how to do a low carb diet, unwittingly sabotaging themselves. This probably contributes to (or reflects) a belief that a large part of the problem is compliance and people "not doing it right". And it's a real problem, no doubt.
But by the same token, knowing that can and does happen masks data that might reveal important exceptions to preferred theories. The guys who insist that caloric restriction must lead to fat loss will always interpret failures as lying or miscalculation and therefore cannot ever have their ideas falsified.
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I've seen Eric Westman talk a few times
He says, unsarcastically, that PhD scientists are incapable of studying obesity and that should be left to "real" doctors like himself (MDs)
He says this at diabetes conferences where the majority of attendees are PhD obesity researchers
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@KetoCarnivore @caloriesproper2 I doubt that clinical experience really brings home the issues.
Like: clinician told me to eat this meal plan. I got super hungry and binged on ice cream.
Did I report the binge to the clinician?
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Whoah!! Bobcat caught on camera mid-day in the open.
This is my family’s place, my nephew installed these cams.
Pretty cool, we caught a bobcat in the open in the daylight with what appears to be a squirrel in mouth.
This is North Country, New York.
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@exfatloss I’d be curious what you thought of this Brad guys schema for modeling what happened in the lab. How we represent what happened and how we assign meaning while still keeping it simple.
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I think you’re on to something here, Ash!
It’s time that food testing left the world of corporate customers and became more accessible to consumers.
Both from a convenience and cost standpoint but also from a “how to interpret this data” standpoint.
Farmer Ash (from the Strong Sistas)@strong_sistas
I am excited to learn about an independent third party food testing lab @test_your_food, launching soon. They won’t just test food, they will interpret and properly assess the data to help us all better understand what those results actually mean in the context of metabolic health. Food testing is certainly very important! It helps us better understand what we are buying and how food actually impacts our health, especially within the modern food system that has undergone some big shifts in production methods, and ultimately in the food we consume.
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