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In the year 2050 the US economy will be ranked by size at what level globally?
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Randall Parker #VaccinesForMoreViruses
74.9K posts
Randall Parker #VaccinesForMoreViruses
@futurepundit
My motto: First, don't die. Speed up biological research.
เข้าร่วม Eylül 2009
1.5K กำลังติดตาม2.4K ผู้ติดตาม
Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
"Despite regulatory success, antibiotic developers face low initial uptake due to stewardship practices, limiting early revenues"
"High development and post-approval costs, combined with limited pricing power and weak acquisition interest, continue to...drive company exits."
Richard H. Ebright@R_H_Ebright
"Iterum Therapeutics is the latest in a growing line of antibiotic makers that have decided to call it quits...[B]etween 2016 and 2026, at least six publicly listed...companies...developing new antibiotics have gone bankrupt...or entered liquidation." insights.citeline.com/scrip/therapeu…
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
The progressive view of crime--that criminals are poor victims of circumstance and thus it is our responsibility to fix them rather than to punish and stop them--is a massive tax imposed on the law-abiding and industrious
Think of the trillions of dollars of urban real estate in cities like Detroit, Memphis, East St. Louis, and so on that are essentially valueless because we refuse to deal harshly with criminals
Meanwhile, Singapore just uses the cane and gallows as necessary, and the result is that it is a very pleasant place in which to live and lacks the blighted swathes of the cityscape that predominate in America
Crémieux@cremieuxrecueil
The majority of crime is done by very few people. We have many exams that speak to this. For example: The number of burglaries in Leinster plummeted after three men died in a car crash.
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
What if Trump were really playing 4D chess, but instead of being a China hawk as Hudson Institute types assume, he was actually Lemoine-pilled on the idiocy of geopolitics and was covertly working to make Chinese regional hegemony so inevitable that it's pointless for the US to even try to prevent it, thereby saving the world from a conflict that would be not only pointless but also incredibly wasteful?
Geoff Wade@geoff_p_wade
"The U.S. Is Pushing Southeast Asia Toward China. The Iran War Made It Worse." by Joshua Kurlantzick cfr.org/experts/joshua…
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
Today I learned that @SFMTA_Muni, @MTA, and @SFBART all have ~20x - 70x more staffing costs on a per rider trip basis than Tokyo's Metro system.
US public transit is a scam that exists to employ politically desirable populations in exchange for votes.
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
"Back in 2017, two academics affiliated with Harvard had created a novel category to describe speech that was factually true, but undermined official interests. They called it malinformation and defined it as speech “based on reality, used to inflict harm..."
unherd.com/2026/04/how-ce…
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Yes, many companies have been exaggerating the role that generative AI has played in layoffs because they don't want to admit that they overhired.
The Stanford Review@StanfordReview
Stanford CS graduates “are struggling to find entry-level jobs,” according to Professor Jan Liphardt. The cause, however, is not AI. A survey of 1,000 hiring managers found that 59% of companies overemphasize AI’s role in layoffs because “it plays better with stakeholders than citing financial constraints.” Steep rate hikes and a cushy entry-level hiring spree during COVID are to blame rather than a convenient technological scapegoat.
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
A fascinating debate about the war is gripping the Arab world, but no one is reporting on it. No one except for the redoubtable @zriboua.
Here's a snippet from Ibrahim Issa, Egyptian Writer, speaking from Cairo with host @Nayef_tv:
"Issa: I hold the Arab political culture responsible since the 1950s and ‘60s until now — the hegemony of the political Islam project and the Nasserist and leftist ideas that dominate Arab culture, control its keys, and reign over it. That is the real problem.
"We are in an inheritance — the dung inheritance, the mental and intellectual dung that dominates and controls the Arab mind."
Read Zineb's substack here: substack.com/home/post/p-19…
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
@brad_polumbo We’re in Rome. Unlike Catholic churches, you can’t just randomly walk in to a temple for services. Always security around. This was our experience in Peru as well. Need to register ahead of time.
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
The Jewish synagogue near me in the suburbs is the only church that has razor wire surrounding and armed guards. Most other churches don’t even have fencing.
The cathedral I attend downtown where there is way more crime and a lot of vagrants has an open door policy. We do have volunteer security (large men who do handle disruptions), but I’m pretty sure they aren’t armed, no fencing, etc..
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
There’s a large building down my street in Miami that I walk by that always has one, sometimes two, armed guards in full bulletproof body armor standing outside it.
Curiosity got the better of me one day, and I looked up what was inside—a jewelry store, perhaps—that needed that kind of heavy-duty protection.
It’s a Jewish center with a daycare.
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
The reason you see dorms or co-living arrangements only in college or the military is because colleges and the military have the ability to summarily evict a troublemaker without going through the 9 month eviction process ordeal that progressives have inflicted on the rest of society.
M. Nolan Gray 🥑@mnolangray
This is the canonically correct form of housing for a young, single person in a superstar city. Essentially the modern version of the boarding house.
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
For $126B, you could buy about 30 Model Ys with FSD per projected daily rider of CA HSR.
Ryan McEntush@rmcentush
For the expected cost of CA high-speed rail, you could buy >250 Boeing 737s and fly every man, woman, and child in San Francisco to LA and back every day for 3.5 years
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
The Industrial Revolution would not have happened if it had begun amid our current institutions, political economy, and level of regulation/procedural roadblocks aka “democratic input.” This is among the starkest challenges facing Western society today, though uncouth to discuss.
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@JigarShahDC Are the state public utility commissions so poorly chosen that they lack the ability to see through whatever deceptions the utilities are using to avoid installing grid enhancing technologies? Or are state legislatures or governors the clueless ones? Or FERC or ISOs or RTOs?
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
Capturing most of that $15B requires about $500m of grid enhancing technologies
Energy Empire Podcast@EnergyEmpirePod
$15B/year wasted because we can't move power from where it's made to where it's needed — and that number has doubled in five years. The grid isn't just underfunded. It's actively costing us.
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The US should eliminate all Achilles Heel threats by targeted acceleration of technological advances and infrastructure. Accelerate development of geothermal energy in the western US combined with NEPA reforms easy permit approvals for data centers on federal lands. en.wikipedia.org/wiki/Federal_l…
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"Carlyle’s Jeff Currie on the structural change coming: The bargain that trades US security for dollar dominance is breaking down That triggers a capital rotation back into physical industries, energy strategy shifts from cooperation to hoarding, and batteries’ new security premium because local, non-portable power is hardest to disrupt. That’s structural regime change, and it’s happening now." @TheNewGoldRush
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A solution would be to fix NEPA and then the US government could do rapid permitting to allow fast massive data center builds in fairly isolated federal lands in the western region. Some areas are extremely sparsely populated. en.wikipedia.org/wiki/Federal_l…
Dean W. Ball@deanwball
If you needed a reminder of why America’s founders were deeply skeptical of democracy and the will of the masses, there is none better than the fact that the American people seem to be enthusiastically banning a wave of industrialization before it has even begun in earnest.
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
@mattyglesias It's a bad explanation.
A better one: The protests went ended bc the university administrator who had been tolerating the lawlessness got the message that they were putting their federal funding at risk.
Suddenly everyone remembered the nuts and bolts of how to enforce rules
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@_brianpotter @razibkhan In some jurisdictions data centers pay most of the taxes for a town or county. Poorer areas ought to seek out data center developers in order to cut home taxes.
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Randall Parker #VaccinesForMoreViruses รีทวีตแล้ว
This is how California became anti-growth in the 60s/70s btw. Citizens just started relentlessly punishing local elected officials that didn't strangle development.
Missi Hesketh for MO 7th@MissiforMO
The City of Festus, MO canceled their Council meeting for tonight following last night's election whereby citizens voted out of office every single member who voted for the data center there that the people did not want. Micro to macro, that is how we hold them accountable.
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