Andy Jatis, PharmD, BCPS, BCCCP

Propofol, a sedative hypnotic, is commonly used for RSI and procedural/ICU sedation but user beware. Propofol Infusion Syndrome (PRIS) although rare is a devastating side effect with up to 70% mortality. But how exactly does Propofol cause PRIS ⁉️ Follow the 🧵to learn more!

Fortunate to have some amazing research mentors during residency! Excited to see this project from PGY1 get to the finish line.

Happy last day of residency to @NikithaYagnala and @jatis_rx! So proud of the incredible critical care pharmacists and people you are. @PennMedicine and @NorthwesternMed are so lucky to have you join their team, we will miss you so much! @MayoPharmRes #pharmicu

Dr. Nick Peters from the @PharmacyToDose critical care podcast provides insight on increasing your podcasting presence. Listen now: ow.ly/KwLT50OB7n3 @jatis_rx

Guess what just released? Two new ACCPPostgrads podcast episodes featuring Drs. Henry Okoroike and Mia Lussier! If you're interested in hearing their experience transitioning to new practitioner roles, listen in: ow.ly/Nz2Q50Nh7ES @henryco32 @MiaLussier

Next 🆙 Dr. Andy Jatis @jatis_rx discusses the ENCHATED2/MT Trial on intensive BP control after endovascular thrombectomy for acute ischemic stroke 🧠 🩺 #NCSPharmJC @neurocritical #PharmICU #NeuroTwitter

In the ECHANTED2/MT trial patients assigned to this intensive SBP goal had worse neurologic or functional outcomes at day 7 and day 90 compared to a non-intensive SBP goal of 140-180 mmHg #NCSPharmJC (2/2)

Clinical pearl 💊In patients with acute ischemic stroke and large vessel occlusion who remain hypertensive after successful endovascular reperfusion with thrombectomy, it is harmful to target a SBP < 120 mmHg (1/)

For a patient with acute ischemic stroke and large vessel occlusion receiving mechanical thrombectomy, what SBP goal do you target after successful endovascular reperfusion if the patient remains hypertensive? @neurocritical #NCSPharmJC

In today's Pharmacy Grand Rounds, @MayoClinicPharmRes @NikithaYagnala and @jatis_rx debate the role of terlipressin in hepatorenal syndrome. #TwitteRx @MayoClinicCCM @MayoClinicGIHep @accpcritprn @SCCM Subscribe to our PGR Podcast at mayocl.in/3jY3o1i

Want to get started in peer review? Get an inside look at the peer review process, including advice on how to get started from Dr. Erika Ernst, @UIPharmacy Associate Professor and JACCP Associate Editor. @JACCPJournal @ErnstErika @jatis_rx anchor.fm/accp/episodes/…

Some great company at the CPP reception last night. ☺️ @SCCM_CPP @MayoPharmRes

Mayo Clinic & Mayo Clinic Health System sites are hosting a virtual information session on 11/08 from 5-6 PM central! PGY1 and PGY1 community programs from Rochester (MN), Austin (MN), Mankato (MN), Eau Claire (WI), and La Crosse (WI) will be present. Register now!

Vasopressin is released by the posterior pituitary when IV volume is ⬇️ V1 agonism 🟰 smooth muscle vasocontraction V2 agonism in renal collecting duct 🟰 increase water retention Given endogenous depletion of vaso in septic shock, start it early w/ NE for multimodal support

Crit Care Lit Review 📒 Vasopressin 💉 VASST: Adding vaso ⬇️catecholamine dose and may reduce mortality for those with lower NE dose (<15 mcg/min) in septic shock VANISH: Adding vaso early to NE may ⬇️ need for RRT VANCS: Vaso ⬇️acute renal failure in vasoplegic shock #PharmICU

@zacroBID @accpcritprn @SCCM_CPP @NikithaYagnala @hannahbrokmeier @Dre_pharmd @nei_scott @pwierusz @EDWieru @KyleHessPharmD @theABofPharmaC @AJWPharm The study title is a bit misleading as the NE+DOB arm only received dobutamine if CI was <= 2.5 after fluid (Figure 1 in study). Aligning with the SSC 2021 Guidelines, NE+DOB should be reserved when concern for mix shock or can switch to EPI monotherapy.

@jatis_rx @accpcritprn @SCCM_CPP @NikithaYagnala @hannahbrokmeier @Dre_pharmd @nei_scott @pwierusz @EDWieru @KyleHessPharmD @theABofPharmaC @AJWPharm Any thoughts on the combination of norepi and dobutamine in the setting of distributive shock?

First stop on the PGY2 Critical Care Literature Review 🚂 Vasopressors with comparison of NE+Dobutamine vs EPI in septic shock🦠💉 🔑EPI causes type-B lactic acidosis due to its beta stimulation =⏫pyruvate dehydrogenase = ⏫ glucose and lactate independent of tissue dysoxia

Tuning in to her first Mayo Clinic Pharmacy Grand Rounds. @jatis_rx PGY2 critical care resident @MayoPharmRes presenting on fluid stewardship in the ICU

@DanielOwuraku Hey Danny! Great question, for now the competition is just open to post-graduate trainees including residents and post-doctoral fellows. Students unfortunately are not eligible this year.

@jatis_rx Helo Dr Is the opportunity opened for foreign students to

Calling all Pharmacy Residents + Fellows 📣If you are looking for a fun way to challenge your ability to interpret and visually display primary literature📚try out ACCP’s 1st ever Visual Abstract Challenge! Not sure how to get started on a visual abstract? Check out this article