Julien Capin

@MolBioMike @paperperday @bio_rat68 We do not need to purify the de novo proteins in this screen - we express them in cell-free and they produce a fluorescence signal only upon interaction with their target

@paperperday @bio_rat68 I still don’t understand how they expressed and purified a de novo protein in under 24 hours.

CF2H: a cell-free two-hybrid platform for rapid protein binder screening "a method for detecting protein–protein interactions by fusing bait and prey proteins to a dimerization-activated DNA-binding domain that triggers transcription upon interaction." nature.com/articles/s4146…

A scalable architecture for tuning multistate differentiation ratios in synthetic microbial consortia biorxiv.org/content/10.648… #biorxiv_synbio

CF2H: a Cell-Free Two-Hybrid platform for rapid protein binder screening biorxiv.org/content/10.110… #biorxiv_synbio

You designed binders for your favourite protein and wish there was a way to experimentally screen them within 24h w/ only a set of pipettes and a plate reader? Check out our Cell-Free 2-Hybrid approach (CF2H) Full post: tinyurl.com/48cz5nb6 Preprint: biorxiv.org/cgi/content/sh…

Our mini review on Microbial Biosensors is out ! 🦠 We talk about recent achievements, discuss challenges and how the use of AI will be key in discovering and engineering new sensing modules. …icro-journals.onlinelibrary.wiley.com/doi/10.1111/17…

Thrilled to share a big part of my PhD work at the @Berger_labs. We turned #baculovirus into protein and DNA co-delivery vectors for #CRISPR genome editing. Many thanks to all the people involved doi.org/10.1093/nar/gk… @fraaulicino @AlexandraH19552 @BristolBiochem @MaxPlanckBris

Less than two weeks left to submit your abstracts for the BioSynSys symposium! Great opportunity to present your research in #synbio at the @lpiparis_. Great venue, exciting sessions (#proteindesign, #cellfree and more..) and FREE registration! Please spread the word! 📢

Our manuscript "Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus" is finally out on @NAR_Open ! academic.oup.com/nar/advance-ar… Congratulations to all the authors! @Berger_labs @jucap_ @BristolBiochem #CRISPR

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

Our latest review is out! We provide some insights into #CRISPR delivery systems. @fraaulicino @Berger_labs

Explore our latest findings on SARS-CoV-2! Great effort from the team! #COVID19 #SARSCoV2 #CryoEM

Our CEO talked to @BristolLive about our work on #COVID19 with @BristolUncover 🔬💉 @jucap_ @BristolBiochem @BrisBioDesign @adamhfinn @Unit_DX @Berger_labs bristolpost.co.uk/news/inside-la…

Scientists at Bristol and @Imophoron are ready to test #COVID19 vaccine candidates in a pre-clinical programme: bit.ly/2JSueSM #WeAreTogether

@Imophoron produced multiple #COVID19 vaccine candidates and joins @BristolUncover COVID-19 Emergency Research Group (UNCOVER). @BristolBiochem @BrisBioDesign @BristolUni @Berger_labs @jucap_ #biotechnology #covid19 #vaccines unitdx.com/new-vaccine-pl…

New Microsoft Research 4-year PhD Scholarship in my lab on "Exploring motif-based design patterns for biological computation". Let's rethink how genetic circuitry is designed and built! DM for further details and please RT. biocomputelab.github.io/docs/msr_phd_a… #synbio #biocomputation #phd

Was definitely worth the hours spent on the confocal 9 🎨 @fraaulicino 👏🏼

Hear @synbioCDT student @jucap_ tell us why international training and scientific collaboration is so important! @BUILAcommittee @MaxPlanckBris @BristolUni @BrisRDIntl youtu.be/JVCHw-eNsVw maxplanck-minimalbiology.bristol.ac.uk/2019/05/24/bet…

T cells can be activated upon recognition of <10 antigens on the surface of other cells. In the latest issue of Immunological Reviews, my supervisor (@dushek) and I discuss the mechanisms enabling this extraordinary sensitivity. Check it out: onlinelibrary.wiley.com/doi/pdf/10.111… @synbioCDT