Looking forward to this year’s @AmDiabetesAssn #ADA2025 #ADASciSessions! I’ll be giving a talk on metabolic regulation by brown fat miRNAs, hope to see you there!
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Marsel Lino
739 posts
Marsel Lino
@m_lin0
Postdoctoral Fellow @Harvard, @HarvardMed, @JoslinDiabetes, studying diabetes and adipose tissue biology.
Boston, MA เข้าร่วม Eylül 2010
1.3K กำลังติดตาม441 ผู้ติดตาม
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More wild news for 2025: After an amazing time at @JoslinDiabetes, I’m starting my own lab this May at @UChicagoMed! Excited to explore RNA modifications, aging, & metabolism.
Huge thanks to mentors, colleagues, and the (mostly supportive, lol) anonymous reviewers!
#NewLab
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Marsel Lino รีทวีตแล้ว
Cool paper from the Treebak lab showing how DICER is quickly downregulated in adipose tissue upon diet-induced obesity and in humans with obesity, representing a hallmark of metabolic dysfunction
Jonas Thue Treebak@treebak
Happy to share our latest work by Søren Madsen and Augusto Peluso! A huge thanks to everyone involved @Metabolcenter and beyond 👍🙏 Rapid downregulation of DICER is a hallmark of adipose tissue upon high-fat diet feeding sciencedirect.com/science/articl…
Campinas, Brasil 🇧🇷 English
Marsel Lino รีทวีตแล้ว
TODAY at 6 PM ET – Join us virtually for a press conference with #UofT Professor Emeritus Geoffrey Hinton, laureate of the 2024 @NobelPrize in Physics.🎥
Watch live: bit.ly/4eAuPFs
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Marsel Lino รีทวีตแล้ว
Mass General and @harvardmed Investigator Gary Ruvkun, PhD, has won the 2024 @NobelPrize in Physiology or Medicine. He is honored for his discovery of small regulatory RNAs. Congratulations! Learn more: spklr.io/6019vzIW
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Marsel Lino รีทวีตแล้ว
A cold-regulated switch allows thermogenesis in brown fat mitochondria - here our @LMU_Muenchen @LMU_Uniklinikum press release!
👇
tinyurl.com/mryd4rae
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Marsel Lino รีทวีตแล้ว
Out now in The EMBO Journal:
Uncoupling is important for brown fat but is coupled respiration regulated, too?
We found that IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis
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embopress.org/doi/full/10.10…
Munich, Bavaria 🇩🇪 English
Excellent work by @FerrazBannitzR and co-authors from the Patti lab @JoslinDiabetes published in @jclinicalinvest! 👇🏻
Rafael Ferraz Bannitz@FerrazBannitzR
I'm thrilled to share with you that our latest research has been published in JCI! We report that the dynamic regulation of serotonin and other tryptophan-derived metabolites is altered in individuals who develop Post-bariatric hypoglycemia (PBH). jci.org/articles/view/…
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Marsel Lino รีทวีตแล้ว
I'm thrilled to share with you that our latest research has been published in JCI!
We report that the dynamic regulation of serotonin and other tryptophan-derived metabolites is altered in individuals who develop Post-bariatric hypoglycemia (PBH).
jci.org/articles/view/…
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Great to see this paper out @Cell_Metabolism. Amazing work by @DarioFDeJesus, Ling Xiao, and the rest of the team.
Cell Metabolism@Cell_Metabolism
New! Online now: m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1 dlvr.it/TD5z2t
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Marsel Lino รีทวีตแล้ว
They were intended to treat #diabetes The other benefits of GLP-1 medicines were first discovered in preclinical research and later confirmed in clinical trials. Fixed it for you @TheEconomist
The Economist@TheEconomist
They were intended to treat diabetes. The other benefits of a new generation of weight-loss drugs were discovered by accident econ.st/3XtVEVH 👇
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Amazing story, especially if you need a reminder to not give up on your projects/dreams, and to always try to separate facts from opinions.
Jeffrey Flier@jflier
My story of GLP1 development being abandoned in early 90’s due to mistaken decisions by a biotech startup and its pharma partner @pfizer is now up @statnews. Drug development is hard, and even the biggest blockbusters can be prematurely abandoned.
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Marsel Lino รีทวีตแล้ว
My story of GLP1 development being abandoned in early 90’s due to mistaken decisions by a biotech startup and its pharma partner @pfizer is now up @statnews. Drug development is hard, and even the biggest blockbusters can be prematurely abandoned.
STAT@statnews
Opinion: Even the biggest future blockbuster drugs can be prematurely abandoned. trib.al/RuP5PUz
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Marsel Lino รีทวีตแล้ว
The endothelin system is traditionally known for regulating vasoconstriction/dilation. Our new paper in @NatureComms shows EDN3-EDNRB induces the browning of human white adipocytes via cAMP-EPAC1-ERK activation. shorturl.at/Os6ET @ChihHaoWang1, Tadataka Tsuji, @FarnazShamsi
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Thanks @TheEndoSociety and @AaronLohr for highlighting our work in brown fat miRNAs!
Endocrine Society@TheEndoSociety
#BrownFat and Metabolic Function | Listen to @m_lin0, discuss his #ENDO2024 presentation, “A New Layer of Endocrine Regulation: Brown Fat Secretes Exosomal MicroRNAs, which Regulate Metabolic Functions and Distal Organs,” in this @Endocrine_News Podcast episode: bit.ly/3T3fkgF
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I officially started my position as Assistant Professor at @uiowabiology this week! I’m so grateful for the opportunity and have felt very welcome. I’m excited to be a part of the community. I want to acknowledge the many people and opportunities that helped me to get here.
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Marsel Lino รีทวีตแล้ว
Thrilled to share our new paper in @NatureComms! 🌟 Adipocytes can directly sense light via photoreceptors, unveiling a novel adipose-hypothalamus crosstalk through histidine. Read here: rdcu.be/dQovk #Science #Research #Metabolism
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Online now @CellReports! Insulin regulates microRNA sorting/secretion into small extracellular vesicles in adipocytes, which go on to regulate insulin action in hepatocytes, implicating adipocyte-derived microRNAs as endocrine regulators.
Cell Reports@CellReports
Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin dlvr.it/T9lvj9
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