Elizabeth Pollina รีทวีตแล้ว

Indeed, clearly supporting the idea that NuA4/TIP60 does not use the same molecular mechanism as SRCAP to engage nucleosomes in order to incorporate H2A.Z. The multiplicity of histone mark reader modules in NuA4 likely playing a role.
The Nogales Lab@NogalesLab
Please also take a look at related work by @rklouder and Carl Wu at @HopkinsMedicine diving into different functional states of the human SRCAP remodeler and a comparison with TIP60. Recently out in @biorxivpreprint biorxiv.org/content/10.110…
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