Simon Keely

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Simon Keely

Simon Keely

@simonkeely

Professional ponderer and tinkerer. Irish, Asian. Gaeilgeoir. Living where beer does flow and men chunder. Not the CEO of BioPrime

Newcastle, New South Wales เข้าร่วม Mayıs 2010
493 กำลังติดตาม555 ผู้ติดตาม
Simon Keely
Simon Keely@simonkeely·
Our latest work by Jennifer Pryor published in @ajpgi This not only provides insight into how the microbiota may influence responses to food, but also models the duodenal eosinophil responses seen in non-Celiac gluten sensitivity and functional dyspepsia.journals.physiology.org/doi/abs/10.115…
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Simon Keely
Simon Keely@simonkeely·
@MarkPimentelMD Do you think that NAC is working solely as a mucolytic? It's a powerful antioxidant also.
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Mark Pimentel MD
Mark Pimentel MD@MarkPimentelMD·
Just published! This paper is a game changer for patients. 1. CdtB causes #IBS 2. Animal model shows #IBS is #SIBO 3. Rifaximin+NAC beats rifaximin in randomized trial. 4. E. Coli and H2S producers are key. Lays groundwork for our human study this fall. nature.com/articles/s4159…
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Simon Keely
Simon Keely@simonkeely·
@PhilipAhern @arjunrajlab Australia brought in a scheme for funding innovative ideas in their main health grant program, irrespective of track record or prelim data but poor adoption by peer reviewers, limited $ in funding pool and grad return to focus on capability means it hasn't really worked.
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PhilipAhern
PhilipAhern@PhilipAhern·
@arjunrajlab I wonder a lot about how many major breakthroughs would make it through the barrier of grant peer review (bacterial repeat sequence grant lacks Significance etc.). Is there a way we can fix this?
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Alexandra Brown
Alexandra Brown@DrBrownAC·
BC. V it’s no mccmxmxdmxm
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Simon Keely
Simon Keely@simonkeely·
@PhilipAhern @wmuee Gah, I am about to give an immunology lecture about this today and now I will be obsessing about not knowing how to answer this. 🤔
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PhilipAhern
PhilipAhern@PhilipAhern·
@wmuee Probably! Could maybe mismatch to a level seen across mice with different twin pairs. But, I presumed this was maybe already known, or answerable theoretically. I just don't know enough about alloreactivity to know.
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PhilipAhern
PhilipAhern@PhilipAhern·
Ignorant question: Would Zinkernagel & Doherty's classic findings show up using human cells, or would alloreactivity mask the requirement for TCR/MHC matching (i.e. did it depend on the level of mismatch seen in different mouse strains; assuming 1970s knowledge re these things)?
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The Manresa lab
The Manresa lab@mario_manresa·
@ucddublin alumni @DecMcCole receiving the APS H. W. Davenport distinguished award in GI physiology and delivering an amazing lecture. Also, making the Irish flag fly high 🇮🇪
The Manresa lab tweet mediaThe Manresa lab tweet mediaThe Manresa lab tweet media
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Simon Keely
Simon Keely@simonkeely·
@jay_horvat Pffft... They needed to include Sadhbh before worrying about the simples ones...
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Jay Horvat
Jay Horvat@jay_horvat·
@simonkeely Surprised Niamh and Siobhan didn't get a run...
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