Sigurgeir Olafsson

Today on #WorldPsoriasisDay, please check out our manuscript that is just out in @NatureGenet about somatic evolution in the skin of psoriasis patients nature.com/articles/s4158…

@sciencejannat @CellGenomics Congratulations Jannat! It took a lot of perseverance to get this out I imagine. Great work 👏

Very excited to share that our work reconstructing chromothripsis has now been published in @CellGenomics! We reconstructed chromosomes with up to 800 rearrangements on a single allele and queried epigenetic and transcriptomic consequences. Thread below! #secsectitle0090" target="_blank" rel="nofollow noopener">cell.com/cell-genomics/…

@alehins @PREDICTIBD Tillykke!

Today is my first day at @PREDICTIBD. I am excited to lead the genomics efforts and to work closely with my colleagues on omics and clinical studies. This is an incredible opportunity to understand IBD pre- and post-diagnosis using the astonishing Danish EHR and molecular data

UK biobank WGS 500k data available science.org/content/articl…

Germline variants at 25 loci influenced the risk of developing CH. These do not show association with cardiovascular disease and Mendelian Randomization further gave no indication that they increase the risk of cardiovascular disease.

Very importantly, this large-scale study of two biobank scale cohorts failed to find evidence that clonal hematopoiesis causes heart disease. It suggests that the associations previously reported are the result of confounding between smoking behaviour and these phenotypes.

Check out this work by my @decodegenetics colleagues, Simon Stacey and Florian Zink, on clonal hematopoiesis that appeared in @NatureGenet today: nature.com/articles/s4158… They show that you can call CH based on a mutation "barcode" in the absence of a typical driver mutation.

@jogleeson_ucsd @naxerova It really was an amazing meeting! So honored to have been invited. It was great to meet you all. Insightful discussions led to a lot of new ideas.

Amazing mtg on all things #somatic #mosaic in Titisee Germany hosted by Boehringer Ingelheim Fonds.

Many thanks to all the co-authors. @anderson_carl, @andrewrjlawson, @Axel_R_Huber, @imartincorena and others not on twitter. It was a pleasure working with you on this project.

The signature also shows a very strong transcription strand bias. This is driven partly by transcription coupled repair but also by transcription-coupled damage, similar to what has been described for SBS16 in the liver.

Today on #WorldPsoriasisDay, please check out our manuscript that is just out in @NatureGenet about somatic evolution in the skin of psoriasis patients nature.com/articles/s4158…

@AlexBickMDPhD @AllofUsResearch @dgmacarthur @ceclindgren @timfrayling @minouye271 @nicolesoranzo @GLettre @samrip @ShaiCarmi @jgustavsmith @andganna @PaulLacaze @drjamesware @nickywhiffin Why is the data not available to for-profit organizations as well? Would allowing pharma access not help maximize patient benefit? It's them that actually make the drugs...

Academics outside the US can now apply to access @AllofUsResearch. Please spread the word! allofus.nih.gov/news-events/an… cc: @dgmacarthur @ceclindgren @timfrayling @minouye271 @nicolesoranzo @GLettre @samrip @ShaiCarmi @jgustavsmith @andganna @PaulLacaze @drjamesware @nickywhiffin