Andrew Jaffe

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Andrew Jaffe

Andrew Jaffe

@andrewejaffe

VP, Head of Data Sciences at @NeumoraTx. Computational biologist, data scientist across #transcriptomics #epigenomics and #psychiatricgenetics. Tweet are my own

Baltimore, MD Sumali Mart 2009
783 Sinusundan1.5K Mga Tagasunod
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Barack Obama
Barack Obama@BarackObama·
USAID has been fighting disease, feeding children, and promoting goodwill around the world for six decades. As this article makes clear, dismantling this agency would be a profound foreign policy mistake - one that Congress should resist. nytimes.com/2025/02/06/opi…
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Robert Kruse, MD, PhD
Robert Kruse, MD, PhD@RobertLKruse·
@AppleHelix Has anyone ever done a trial where both groups start out on placebo, and then patients who respond on placebo become excluded, and the remaining patients get randomized on drug or not. That could solve this issue and also eliminate sites that bias placebo scores.
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Andrew Jaffe
Andrew Jaffe@andrewejaffe·
@shyam_lab @lpachter I would also guess reporting ' # significant at p < x' eg a fixed pvalue threshold would be less pronounced since fdr /qvalue is more sensitive to small shifts in pvaluesl distributions
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Shyam Prabhakar Lab
Shyam Prabhakar Lab@shyam_lab·
@lpachter Trying to explain the (most likely artifactual) peak at 44yrs. Perhaps it's because subjects >44yo were enriched for high BMI (Ext Data Fig 1a) + European ancestry (c), while subjects <44yo had missing diabetes data (d). Linear regression of confounders may not be enough here.
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Andrew Jaffe
Andrew Jaffe@andrewejaffe·
@raungar nice paper! was diff expression impacted at all by choice of genome build, eg of t-stats comparing pairs of tissues to each other? its not clear expression counts should be comparable across different references (as you showed), but like blood vs muscle should overlap more...
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Rachel Ungar
Rachel Ungar@raungar·
Want to understand what might be happening in your own data? Check out our supplementary tables where we provide all our results as a reference - we suggest using the list to flag your own data!
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Keri Martinowich
Keri Martinowich@martinowk·
Excited to announce my promotion @LieberInstitute to Senior Investigator and take on role of Director of Translational Neuroscience where I will help provide leadership for the Institute's mission in translating molecular mechanisms of brain disorders into clinical advances
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Alexis Battle
Alexis Battle@alexisjbattle·
As of Jan 1, I have been promoted to (full) Professor of BME @JHUBME! Thank you first to my students & lab members for amazing work. And mentors & collaborators. And the supportive colleagues & leadership across @JohnsHopkins @HopkinsEngineer, a great place to grow a career.
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Keri Martinowich
Keri Martinowich@martinowk·
We have several open research assistant/associate positions on our extended team (me, @kr_maynard, @CerceoPage). Projects are generating transcriptome-scale maps in various human 🧠 regions to understand spatial gene expression in neuropsychiatric & neurodevelopmental disorders
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Kristen R Maynard
Kristen R Maynard@kr_maynard·
Delighted to be a new associate member of the @ACNPorg community. Big thanks to my outstanding mentor @martinowk and collaborators, colleagues & nominators who supported me along the way. Attending #ACNP2023 virtually this year, but celebrating with a fist bump from my newborn!
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Keri Martinowich
Keri Martinowich@martinowk·
Big congratulations to all the new Associate Members, but seeing your former trainees on that list is extra special - huge congrats @kr_maynard - so glad to have you in @ACNPorg as a member! We are lucky to have you! #ACNP2023
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Keri Martinowich
Keri Martinowich@martinowk·
I am truly honored to receive this - @ACNPorg has been a very important part of my career. Huge thanks to my nominator @Dr_Weinberger and @LieberInstitute for giving me the opportunity and resources to build our research program into what it has become.
Neuropsychopharmacology@npp_journal

Time for more awards!🏆 The Daniel H. Efron Research Award to a young scientist on the basis of outstanding basic research contributions to neuropsychopharmacology The #ACNP2023 winners are Dr Keri Martinowich (@martinowk) @LieberInstitute & Dr Vikaas Sohal (@sohallab) @UCSF

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Neumora
Neumora@NeumoraTx·
We have been working hard this year! Our annual company research poster session offers team members the opportunity to share their work with cross-functional colleagues & showcase their achievements. We had a great afternoon discussing the innovative projects teams are advancing.
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Sean Kross
Sean Kross@seankross·
Bringing the heat
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Andrew Jaffe
Andrew Jaffe@andrewejaffe·
@LHSanders14 @DukeHealth @DukeMedSchool super interesting paper! could you possibly clarify the interpretation of the various y-axes of "# lesions per 10kb" in many of the figures? they seem scaled to 1 but its unclear how exactly (and makes it kind of hard to compare across cohorts). thanks!!
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Keri Martinowich
Keri Martinowich@martinowk·
I am so excited and very proud of @rodriguez_lion for unanimous pass on his dissertation defense today. Lionel's thesis has looked at how inputs from basolateral amygdala to the lateral septum regulate BDNF-TrkB signaling in septal neurons to control social behavior.
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Tuklasin

@RobertLKruse @AppleHelix @shyam_lab @lpachter @raungar @martinowk @LieberInstitute @alexisjbattle