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aqdev
7.2K posts


The military spokesperson of the Houthis in Yemen stated:
“This war is the war of the entire Ummah.
The United States, together with Israel, attacking Iran aims to leave the region entirely under Israeli control.
This would mean the destruction of the freedom, independence, and dignity of the Islamic world.
We will target American ships and warships in the Red Sea.”
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@GoldTelegraph_ @ResourceWars_ Now it makes sense why computer components went up in price a lot last year, it was not just because of AI data centers.
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The largest gas system in the world, in Qatar, is now facing 17% LNG capacity offline for potentially up to five years.
This is very bad and I don’t think the public has fully grasped the impact of this.
Get used to seeing this:
“Force majeure.” @ResourceWars_
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@Bubblebathgirl @jmon131032471 The goat is not antisemite and racist at least...
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@jmon131032471 I can’t tell which is more attractive.
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Mayor Mamdani’s homophobic, racist terrorist-sympathizing wife, who recently got exposed called black people ni***rs and gay people f**s, has shut down her 𝕏 account.

Spitfire@RealSpitfire
Mamdani’s wife deactivated her X acct. Imagine THAT! Good thing people got screenshots!😎
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@Ab83126691 @ArmstrongEcon Iranians don't support their terrorist government, I know Iranians inside and outside of Iran in many countries.
They want a secular democratic Iran without islamism.
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@aqdev @ArmstrongEcon U have no idea how the Iranians actually support their govt, Loathe the stooge Shah-he will not even step in Iran! Pl see some independent journos rots out if Iran, shadowbanned on X, anything other than Israrli propaganda.
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It’s a mistake to compare antidepressants and psychedelics. Psychedelics greatest benefit is not chemical, but psychological if used with the intention of healing.
Antidepressants fake happiness chemically while psychedelics make people aware of their own life. It’s the awareness that cures depression.
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🚨MAJOR NEW PAPER 🚨 just out in @JAMAPsych : Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions (tinyurl.com/yu2rbtaf).
I am very proud of this one, was a lot of work for me - both co-first and last author! Eternal gratitude to co-first @QuantPsychiatry and twitterless Hannah Barnett!
The premise is that it is biased to compare open-label trials (=where patients know what treatment they are getting) to blind trials (=where patients do NOT know what they are getting). Open-label trials would gain an unfair advantage by higher placebo response. Even formally blinded psychedelic trials are practically open-label as its obvious to distinguish placebo from 25mg of #psilocybin. In contrast, traditional antidepressants (SSRIs/SNRIs) trials are are close to be truly blind (Lin 2022). Given the bias of open-label vs. blinded comparison, we compared the efficacy of psychedelic-therapy (which is practically always open-label) vs. open-label antidepressants for the treatment of major depression.
We tested 3 prior hypothesis:
- There will be a significant difference between psychedelic-therapy vs. open-label antidepressants, favoring psychedelic-therapy.
- There will be a significant difference between blinded and open-label antidepressants trials, favoring open-label.
- There will NOT be a significant difference between blinded and open-label psychedelic-therapy, as practically they are always open-label.
In contrast with our prior hypothesis, we did not find psychedelic-therapy to be more effective than open-label antidepressants (H1). Not only was the difference not clinically meaningful, but practically there was no difference at all. This finding means that antidepressants administered knowingly to patients, which is the case in real-life medical practice, is as effective as psychedelic-therapy. This result was robust across variations in study selection, including when we removed psychedelic-therapy trials on treatment-resistant depression.
We also assessed the impact of blinding in both psychedelic-therapy and antidepressants trials. We found that for antidepressants (H2), but not for psychedelic-therapy (H3), open label is associated with better outcomes than blinded treatment. However, even in the case of antidepressants, the difference was practically small (~1.3 HAMD units).
How come hypothesis 1 failed, i.e. that psychedelic-therapy is no ore effective than open-label antidepressants, given that antidepressants trials are famous for small drug-placebo difference (~2.4 HAMD units), while psychedelic-therapy trials reported large effects (~7.3)? The key factor is that in psychedelic trials the placebo response is about 50% relative to antidepressants, ~ 4 vs 8 HAMD units (Hsu 2024, Hieronymus 2025). This suppressed placebo response leads to an inflated between-arm difference, as the treatment arm is measured against a lower floor.
The suppressed placebo response in psychedelic-therapy trials is likely attributable to the ‘know-cebo’ effect, i.e. the disappointment when patients realize they are in the control group. In psychedelic-therapy trials, this placebo suppression accounts for 4.0 / 7.3 ~ 55% of the specific treatment effect. In other words, ~55% of psychedelic-therapy’s effect is not explained by patient improvement after the treatment, but rather by the lack of improvement in the placebo group.
In summary, we found that for the treatment of depression, psychedelic-therapy is no more effective than open-label SSRIs/SNRIs. Our results for psychedelics are twofold: psychedelic-therapy demonstrated a robust and large therapeutic effects (~12 HAMD units), which justifies optimism. On the other hand, psychedelic-therapy’s lack of superiority compared to open-label SSRIs/SNRIs highlights the influence of blinding integrity and argues against overly optimistic narrative's about psychedelic-therapy's potential.

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@_A_khalifa Look at the horror in their eyes, they know what might happen once they end up inside their jail: brutal torture, gang rapes, and they might not get out alive.
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@BasedBiohacker Combining a high dosage of armodafinil and caffeine is a recipe for anxiety.
Adderall or Vyvanse works well without inducing anxiety.
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you want adderall focus and motivation but don't want to fry your brain and end up a retarded junkie licking dope off the pavement on skid row?
this is your recipe:
upon waking, empty stomach: 200 mg caffeine, 500 mg l-tyrosine, 150 mg armodafinil, 50 mg bromantane, 2 mg pinealon
after 2 hours: 800 mg l-theanine
your brain is about to be operating on a level you did not even fucking know existed before, longer than you've ever been able to focus before. i'm talking a weeks worth of work done in a sitting. and quality work - not fake productivity with sloppy results. the flow goes deep, so set a timer to remember hydration.
- epitalon for circadian rhythm, bpc-157 for gut-brain axis and gut health, citicoline for choline replenishment, magnesium l-threonate for neuroprotection and cognitive health.
this stack is literally neuroprotective, enhances neuroplasticity, and promotes neurogenesis.
it's that easy. you can rip this 5 days a week, no issue. cycle off bromantane, epitalon, pinealon and bpc after 30 days, wait a 1-2 months then run another cycle. boom. you are now tony stark without sacrificing tomorrow or burning your own brain.
not medical advice. US sources i use below, more linked in website in profile.
armodafinil: modafinilxl.com/buy/waklert-do…
bromantane: swisschems.is/product/broman…
pinealon: yourprotocol.co/products/pinea…
epitalon: yourprotocol.co/products/epita…
bpc-157: yourprotocol.co/products/bpc?s…
citicoline: nootropicsdepot.com/cognizin-citic…
magnesium l-threonate: nootropicsdepot.com/magtein-magnes…
l-theanine: nootropicsdepot.com/l-theanine-cap…
l-tyrosine: nootropicsdepot.com/l-tyrosine-cap…


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@HashemAllMighty I root for their citizens, not their terrorist governments.
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@patriot_apranik @Reuters Replacing current regime with the MEK terrorists is like going from the 5th level of hell down to the 7th level.
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Today, I watched a video of 50 EU politicians failing to find Iran on a map, and I thought the absurdity couldn't get any worse. Then I saw this @Reuters article.
A so-called reputable news agency is actually promoting the MEK (Rajavi's Marxist-Islamist cult) as a “transitional government” for Iran! The MEK is the exact same terrorist group that partnered with Khomeini to cause the 1979 disaster.
The dark comedy of Western media and politicians trying to dictate Iran's future while being completely clueless never ends. Let me make it clear: The Iranian people despise the MEK just as much as they despise the Mullahs!



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Iranians rally in Brussels urging EU to back NCRI provisional government x.com/i/broadcasts/1…
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@memarsadeghi The regime will collapse sooner or later due to the war, and people will finalize the revolution inside of Iran.
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@GoldForecast Take David Hunters predictions with a grain of salt…
His prediction levels take much longer time than he expects.
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@BosevskiGorgi You will understand Jesus better after one heroic dose of mushrooms than going to church every sunday the rest of your life
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@PeterSweden7 USA is the definition of democracy: free speech compared to EU countries where you can get jailed or fined for social media posts.
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