aqdev

Bitcoin long term prognosis: Bottoming around 50-60K by mid 2026 Next top 200K by 2029 What happens afterwards depends on bitcoins adaptation by AI-agents, if usage becomes widespread BTC could go to millions in the next decade #BTCUSD $BTCUSD $BTC

@Ab83126691 @ArmstrongEcon Iranians don't support their terrorist government, I know Iranians inside and outside of Iran in many countries. They want a secular democratic Iran without islamism.

@aqdev @ArmstrongEcon U have no idea how the Iranians actually support their govt, Loathe the stooge Shah-he will not even step in Iran! Pl see some independent journos rots out if Iran, shadowbanned on X, anything other than Israrli propaganda.

Because the IRGC is hard core religious, this makes it impossible to see them take some sort of leadership role. The best we can hope for is someone from the regular army rises up, but that could also end up in civil war.

@Nostre_damus Russia cant take down Ukraine 😉

If Iran can take down a F-35, what can Russia & China do ?

It’s a mistake to compare antidepressants and psychedelics. Psychedelics greatest benefit is not chemical, but psychological if used with the intention of healing. Antidepressants fake happiness chemically while psychedelics make people aware of their own life. It’s the awareness that cures depression.

🚨MAJOR NEW PAPER 🚨 just out in @JAMAPsych : Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions (tinyurl.com/yu2rbtaf). I am very proud of this one, was a lot of work for me - both co-first and last author! Eternal gratitude to co-first @QuantPsychiatry and twitterless Hannah Barnett! The premise is that it is biased to compare open-label trials (=where patients know what treatment they are getting) to blind trials (=where patients do NOT know what they are getting). Open-label trials would gain an unfair advantage by higher placebo response. Even formally blinded psychedelic trials are practically open-label as its obvious to distinguish placebo from 25mg of #psilocybin. In contrast, traditional antidepressants (SSRIs/SNRIs) trials are are close to be truly blind (Lin 2022). Given the bias of open-label vs. blinded comparison, we compared the efficacy of psychedelic-therapy (which is practically always open-label) vs. open-label antidepressants for the treatment of major depression. We tested 3 prior hypothesis: - There will be a significant difference between psychedelic-therapy vs. open-label antidepressants, favoring psychedelic-therapy. - There will be a significant difference between blinded and open-label antidepressants trials, favoring open-label. - There will NOT be a significant difference between blinded and open-label psychedelic-therapy, as practically they are always open-label. In contrast with our prior hypothesis, we did not find psychedelic-therapy to be more effective than open-label antidepressants (H1). Not only was the difference not clinically meaningful, but practically there was no difference at all. This finding means that antidepressants administered knowingly to patients, which is the case in real-life medical practice, is as effective as psychedelic-therapy. This result was robust across variations in study selection, including when we removed psychedelic-therapy trials on treatment-resistant depression. We also assessed the impact of blinding in both psychedelic-therapy and antidepressants trials. We found that for antidepressants (H2), but not for psychedelic-therapy (H3), open label is associated with better outcomes than blinded treatment. However, even in the case of antidepressants, the difference was practically small (~1.3 HAMD units). How come hypothesis 1 failed, i.e. that psychedelic-therapy is no ore effective than open-label antidepressants, given that antidepressants trials are famous for small drug-placebo difference (~2.4 HAMD units), while psychedelic-therapy trials reported large effects (~7.3)? The key factor is that in psychedelic trials the placebo response is about 50% relative to antidepressants, ~ 4 vs 8 HAMD units (Hsu 2024, Hieronymus 2025). This suppressed placebo response leads to an inflated between-arm difference, as the treatment arm is measured against a lower floor. The suppressed placebo response in psychedelic-therapy trials is likely attributable to the ‘know-cebo’ effect, i.e. the disappointment when patients realize they are in the control group. In psychedelic-therapy trials, this placebo suppression accounts for 4.0 / 7.3 ~ 55% of the specific treatment effect. In other words, ~55% of psychedelic-therapy’s effect is not explained by patient improvement after the treatment, but rather by the lack of improvement in the placebo group. In summary, we found that for the treatment of depression, psychedelic-therapy is no more effective than open-label SSRIs/SNRIs. Our results for psychedelics are twofold: psychedelic-therapy demonstrated a robust and large therapeutic effects (~12 HAMD units), which justifies optimism. On the other hand, psychedelic-therapy’s lack of superiority compared to open-label SSRIs/SNRIs highlights the influence of blinding integrity and argues against overly optimistic narrative's about psychedelic-therapy's potential.

@_A_khalifa Look at the horror in their eyes, they know what might happen once they end up inside their jail: brutal torture, gang rapes, and they might not get out alive.

Never forget WHY the mullah regime in Iran NEEDS to collapse!

@BasedBiohacker Combining a high dosage of armodafinil and caffeine is a recipe for anxiety. Adderall or Vyvanse works well without inducing anxiety.

you want adderall focus and motivation but don't want to fry your brain and end up a retarded junkie licking dope off the pavement on skid row? this is your recipe: upon waking, empty stomach: 200 mg caffeine, 500 mg l-tyrosine, 150 mg armodafinil, 50 mg bromantane, 2 mg pinealon after 2 hours: 800 mg l-theanine your brain is about to be operating on a level you did not even fucking know existed before, longer than you've ever been able to focus before. i'm talking a weeks worth of work done in a sitting. and quality work - not fake productivity with sloppy results. the flow goes deep, so set a timer to remember hydration. - epitalon for circadian rhythm, bpc-157 for gut-brain axis and gut health, citicoline for choline replenishment, magnesium l-threonate for neuroprotection and cognitive health. this stack is literally neuroprotective, enhances neuroplasticity, and promotes neurogenesis. it's that easy. you can rip this 5 days a week, no issue. cycle off bromantane, epitalon, pinealon and bpc after 30 days, wait a 1-2 months then run another cycle. boom. you are now tony stark without sacrificing tomorrow or burning your own brain. not medical advice. US sources i use below, more linked in website in profile. armodafinil: modafinilxl.com/buy/waklert-do… bromantane: swisschems.is/product/broman… pinealon: yourprotocol.co/products/pinea… epitalon: yourprotocol.co/products/epita… bpc-157: yourprotocol.co/products/bpc?s… citicoline: nootropicsdepot.com/cognizin-citic… magnesium l-threonate: nootropicsdepot.com/magtein-magnes… l-theanine: nootropicsdepot.com/l-theanine-cap… l-tyrosine: nootropicsdepot.com/l-tyrosine-cap…

@HashemAllMighty I root for their citizens, not their terrorist governments.

The Islamic regime keeps attacking Qatar. So who are you rooting for? The Muslim terrorists… or the Muslim terrorists?

@patriot_apranik @Reuters Replacing current regime with the MEK terrorists is like going from the 5th level of hell down to the 7th level.

Today, I watched a video of 50 EU politicians failing to find Iran on a map, and I thought the absurdity couldn't get any worse. Then I saw this @Reuters article. A so-called reputable news agency is actually promoting the MEK (Rajavi's Marxist-Islamist cult) as a “transitional government” for Iran! The MEK is the exact same terrorist group that partnered with Khomeini to cause the 1979 disaster. The dark comedy of Western media and politicians trying to dictate Iran's future while being completely clueless never ends. Let me make it clear: The Iranian people despise the MEK just as much as they despise the Mullahs!

Iranians rally in Brussels urging EU to back NCRI provisional government x.com/i/broadcasts/1…

@memarsadeghi The regime will collapse sooner or later due to the war, and people will finalize the revolution inside of Iran.

No country can defeat the US military, much less Iran’s decrepit Islamist theocracy. So they will try to create chaos enough to make Americans demand an end to the war. The way to counter this is to commit to progressively heavier assaults for an unlimited time horizon.

@GoldForecast Take David Hunters predictions with a grain of salt… His prediction levels take much longer time than he expects.

David Hunter reiterates silver target of $180 and gold target of $6800 in 3 months. 🤨

@TMT_arabic IRGC is begging to get nuked

🚨 Trump: We destroyed 100% of Iran’s military capabilities‼️ 🚨 Meanwhile, Iran has unveiled one of its underground ballistic missile cities 🫣

@BosevskiGorgi You will understand Jesus better after one heroic dose of mushrooms than going to church every sunday the rest of your life

the forbidden fruit

@BRICSinfo No Hormuz for you! (unless you pay)

JUST IN: 🇮🇷 Iran considers charging taxes and toll fees to cross the Strait of Hormuz.

@seth_fin Even retail traders can win the game if they: -Don't use leverage -DCA instead of trying to time the market -Buy more on dips -Are patient and hold years instead of days -Dont use stop loss

BTC DUMPS -9.47% or 7200 USD in 3 days. Do you think it is Organic? People don't hate the manipulation enough. I see all the data and I can say, retail traders are being played like a fiddle. 😂

@PeterSweden7 USA is the definition of democracy: free speech compared to EU countries where you can get jailed or fined for social media posts.

7 of 10 Swedish people don't believe the USA is a democracy anymore. Meanwhile there was 750 bombing attacks in Sweden the last 5 years.

@AutismCapital @bryan_johnson He could probably avoid that side effect with microdosing instead of macrodosing.

@bryan_johnson Today we learned mushrooms make your sperm less motile.

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

@bryan_johnson @bryan_johnson I suggest you experiment with microdosing psilocybin next time to see if you get the longevity benefits without tripping.

@hajiyev_rashad What I don't like with gold and silver miners is the rapid corrections, both in time and price (20-30% in 1-2 weeks) Even if you have the perfect method to find the top you will easily lose 10% trying to exit on the first or second day of the correction

I can't find anything similar price pattern in the senior gold miners GDX...

@OlssonKarin @inashmdn Många ungdomar saknar kritiskt tänkande. De ser många videos på TikTok och Instagram som sprider samma budskap och tolkar det som fakta. Iran o Ryssland använder medvetet både influencers och bottar världen runt för att sprida propaganda och lögner.

Mörkt att den här antisemitiska och konspiratoriska världsbilden möter så många ungdomar i sociala medier. Läs @inashmdn expressen.se/nyheter/sverig…

@Micro2Macr0 45-55 will be the last time you are able to buy cheap silver

From a technical perspective and macro, $silver should find pretty strong support in the $50 range. It's basically just the back test we never got.