Alexandra Mattei

What does DNA methylation do again? Our answer in 32 short pages. Excited to finally get to share a true labor of love Nina Bailly and I worked on together throughout the pandemic, a swan song to my PhD and time in Germany. sciencedirect.com/science/articl…

Our new work is out today! Long time in the oven, this has been a really fun and informative collaboration led by Dhanur Iyer in my lab and @HK_Heidar from @NRivron lab. We show that human embryonic cells have an inherent potential to regulate their developmental timing.

Fresh out of the press @Dev_Cell! w Z. Smith @YaleGenetics and B. Law & M. Chan @Princeton we engineer a high-content molecular recorder to reconstruct thousands of cell lineages during embryoid morphogenesis. #MeissnerLab @MPI_MolGen. A🧵(1/14) authors.elsevier.com/sd/article/S15…

Let's see if Twitter still works. Interested in a POSTDOC position? Stem cells or chromatin or dormancy or metabolism? Take your pick and come join us in Berlin. Email me with CV and LOI. Please RT 🙏

Bird and Bestor had this truly nasty feud back in the 1990s (so I heard), but at least on this issue, they both made great points! (from DNA methylation: a historical perspective from @AL_Mattei, Bailly & Meissner, which is truly a must-read doi.org/10.1016/j.tig.…)

Reminder that our department, MCB, has an Assistant Professor Search underway. Deadline November 1. Apply and spread the word! mcb.harvard.edu/department/new…

Our PhD call is open. If you have a strong passion for developmental biology or epigenetics, or better, developmental epigenetics, then apply to our lab! molgen.mpg.de/IMPRS

🚨I am *super* excited to announce that I will be joining @ARIA_research as a Programme Director!!🚨 I will be exploring how we can leverage principles from physics⚛️, engineering🤖 and biology🧬to develop next-gen neurotechnologies🧠 Here are some questions I’m excited about...

💥We're hiring! Two fully-funded postdoc positions at my lab at the NIH intramural program in Frederick, MD. We are mapping the structure of whole proteomes using crosslinking MS and structure modeling. At one of the most dynamic scientific institutes! Links are below.

💥first paper from the Kraushar Lab💥 @MPI_MolGen how proteostasis builds the most evolutionarily advanced brain region - the neocortex buckle up folks: a thread with history, summary, and perspective nature.com/articles/s4159…

Today we share in @nchembio our development of base editor scanning to chart DNA methyltransferase 3A sequence-function. Congrats to @nicklue8, @Emma_M_Garcia_1, @liaulab, & thanks to @JohnDoench! We're grateful to @DamonRunyon for invaluable support. nature.com/articles/s4158…

Confused by all the "what is epigenetics" discourse? Well I have just the thing for you -- presenting the Epigenetics Alignment Chart!

📢Paper alert!! I'm over the moon! Our #hypoxia study is out on @development! 🥳 –amazing work in the @bulutkarslioglu lab at @MPI_MolGen and in collaboration with @teamstembryo at @mpicbg (1/9) journals.biologists.com/dev/article/14…

I’ve been in an industry job for almost a week and a half. Having transitioned away from academia, these are my musings: a 🧵. #AcademicChatter @AcademicChatter #AcademicTwitter #alt_ac

Our review on new opportunities offered by single-cell technologies for investigating epigenetic regulation during mouse development is out today in @sciencedirect! A team effort with @helenekretzmer and Alex Meissner @MPI_MolGen. A short thread🧵 sciencedirect.com/science/articl…

Cheers to the new Jeffrey Leiden Center for Cell and Genetic Therapies, and we’re excited to announce we’re building the Leiden Campus, which will include a new cell and genetic therapies research and manufacturing facility in Boston’s Seaport. Learn more: bit.ly/3wy90lh

@dvir_a @CJCHCM We do indeed cite his important work, for example reference 129 Gruenbaum, Cedar & Razin, and reference 108 Vardimon et al. We wish we could have included even more if space limits had allowed.

@CJCHCM Just unbelievable that they left out *ALL* of Howard Cedar's ground-breaking work in this field. None of his papers is cited and he is not mentioned even once. Sorry, but this seems yet another attempt to rewrite history. Reminds me of Lander's CRISPR heroes paper.

Excellent historical review about DNA methylation cell.com/trends/genetic…

Excited to share my PhD work now out @NatureCancer! We explored the methylome of acute lymphoblastic #leukemia and found that unlike the classic global hypomethylation found in tumors, ALL exhibits strikingly high genome-wide #DNAmethylation levels. nature.com/articles/s4301…

Excited to share our latest study on #DNMT3A identifying a new chromatin reader domain in the N-terminus that is essential for post-natal life. rdcu.be/cNbF5

Also big thank you to @TrendsGenetics for supporting us in exploring this idea fully by providing us the generous space needed to do so!

We hope our historical retelling of the emergence and progress of the field of DNA methylation helps highlight how much insight can be gleaned from a single well designed experiment, and how ideas can be refined or even overturned completely in light of new data.

What does DNA methylation do again? Our answer in 32 short pages. Excited to finally get to share a true labor of love Nina Bailly and I worked on together throughout the pandemic, a swan song to my PhD and time in Germany. sciencedirect.com/science/articl…