Bajpayee Lab

Recap on last week's seminar! Dr. Chris Evans, professor of orthopedics at the Mayo Clinic @MayoClinic, visited Northeastern University and gave a wonderful seminar talk. It was great to learn about his amazing work in osteoarthritis IL-1RA gene therapy!

Engineered catIL‑1RA shows superior joint retention and blocks IL‑1–driven cartilage inflammation far better than Anakinra. Single‑dose intra‑cartilage depots protect tissue for 16 days with 25× higher synovial levels in vivo. sciencedirect.com/science/articl…

We are excited to share our newest work by Dr. Boyer @Boyer_TL et al on engineered cationic Interleukin-1 receptor antagonist for OA treatment!

These key barriers include cartilage, the blood–brain barrier, the GI tract, the eye, and the skin, and the effects on PK and tissue transport. We also present engineering design principles to enhance EV targeting and overcome these barriers for more effective therapeutics.

Our new review, led by Helna, which examines how extracellular vesicles (EVs) interact with key biological barriers, is online now! sciencedirect.com/science/articl…

Encapsulation within alginate-core polymeric microparticles (AlgPLGA-MP) extended pain relief to approximately one week, while avidin surface modification further enhanced joint retention and shows promise for prolonging analgesic effects even further.

We demonstrate that Neosaxitoxin (NSTX) is a potent analgesic for osteoarthritis (OA) associated pain but is limited by rapid joint clearance and short therapeutic duration when delivered as a free drug.

We are thrilled to share our latest work led by @Henry2833884 titled “Extended osteoarthritis pain relief with neosaxitoxin using alginate-core polymeric microparticles” published in @nanoscale_rsc Link: pubs.rsc.org/en/content/art…

Come see us at ICRS 2025 18th World Congress in Boston! Dr. Bajpayee and Helna Baby will present our works on Extracellular Vesicles (EVs) at session 1.1 elEVate Your Game of ICRS 2025 (Sat 10/11) #ICRS #Cartilage

Congratulations to Dr. Timothy Boyer @Boyer_TL for successfully defending his doctoral thesis! Tim’s work has focused on designing cartilage targeting cationic fusion proteins for the treatment of OA. Tim is heading to Rush University for his postdoc! He will be missed very much!

Congrats to the Authors! @billlhakim, @Boyer_TL, @ChakraSrirupa, and @AmbikaBajpayee. @NUBioE1 @cilsinstitute

By combining experimental and computational approaches, we investigated the contribution of charge and hydrophobicity arrangement on cationic peptide’s intra-cartilage transport. We found that there is an optimum cationic peptide's residue configuration for cartilage targeting.

We are thrilled to share our latest work titled "Spatial charge-hydrophobicity configuration modulates cationic peptide transport in cartilage," published in @BiophysJ Free access: authors.elsevier.com/c/1lsw91SPTBhRI

Congrats to Tim on his first first-author paper, and co-authors Olivia Chao, @billlhakim, Luke Childress, @meslier_q (shoutout for first lightsheet image), and computational help from @MJchemist and Suhasini Iyengar. @AmbikaBajpayee @cilsinstitute @NUBioE1

In collaboration with Dr. Ryan Porter at UAMS, we demonstrate Cationic Peptide Carriers (CPCs) target the deep layers of rabbit knee cartilage, even in inflamed joints, and can be utilized to substantially improve intra-joint retention of DMOADs.

Calling all Disease-Modifying OA Drugs‼️ We are excited to share new work led by @Boyer_TL now published in @OACJournal on evaluating Cationic Peptide Carriers for drug delivery of DMOADs in an animal model of post-traumatic osteoarthritis. Free Access: authors.elsevier.com/c/1kyZk3npMrf-…

Congrats to our fantastic @Northeastern students and faculty at the Academic Honors Convocation.news.northeastern.edu/2025/04/16/aca…

Excited to share that an editorial was published on our recent paper by Dr. Chris Evans on IL-1RA delivery to chondrocytes via surface-engineered exosomes! Huge thanks to the editors @OACJournal for the spotlight! Check it out! sciencedirect.com/science/articl…

Meet us in Chicago! Bajpayee Lab is excited to share new work on cationic drug delivery for osteoarthritis treatment #SFB2025 @SFBiomaterials #DrugDelivery #GeneTherapy #OAtreatment

We are thrilled to share our latest work on surface-engineered exosomes for sustained interleukin-1 receptor antagonist (IL-1RA) delivery to cartilage via electrostatic interactions, now published in Osteoarthritis and Cartilage! @OACJournal Check it out! sciencedirect.com/science/articl…