Gautam Dey (@Dey_Gautam, @embl) delivered a fantastic @EMBO_YIP Lecture today as part of the MBGE Seminar Series at @KocSciences @kocuniversity.
Thank you for the energy, enthusiasm, and inspiration you shared with us and our students!
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Caydasi Lab - Cell Cycle & Genome Stability
268 posts
Caydasi Lab - Cell Cycle & Genome Stability
@CaydasiLab
Cell Cycle & Genome Stability Lab @kocuniversity
Koç University, Istanbul شامل ہوئے Ağustos 2019
538 فالونگ762 فالوورز
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🎉🍾Excited to share our #Asgardarchaea #odin #cytoskeleton study published in @embojournal
Dual FtsZ proteins in Odinarchaeon form distinct filaments—shedding light on tubulin/FtsZ evolution. Brilliantly led by @Jayantikri23 embopress.org/doi/full/10.10…
Saravanan Palani@syncellbiolab
Thrilled to share our lab's first evolutionary cytoskeleton study! We uncover two distinct FtsZ paralogs in Odinarchaeota—OdinFtsZ1 forms curved filaments, while OdinFtsZ2 assembles into spiral rings. A glimpse into tubulin evolution! #Eukaryogenesis #AsgardArchaea #cytoskeleton
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Caydasi Lab - Cell Cycle & Genome Stability ری ٹویٹ کیا
Cargo adaptors use a handhold mechanism to engage with #myosin V for #organelle transport, say Hye Jee Hahn, Natalya Pashkova, Michael Cianfrocco, & Lois Weisman @umlifesciences
hubs.ly/Q03mXFwQ0
#Microbiology #Organelles #Trafficking
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Caydasi Lab - Cell Cycle & Genome Stability ری ٹویٹ کیا
Excited to share our new preprint on @biorxivpreprint!
We show that USP28 mutations found in cancer block its interaction with 53BP1, disrupting p53 stabilization. Check out the full story...
biorxiv.org/content/10.110…
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Caydasi Lab - Cell Cycle & Genome Stability ری ٹویٹ کیا
Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhav_dhar in collab with @Sudiya14 @deepak_iisc #actin biorxiv.org/content/10.110…
GIF
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@isil_aksan Sabırlar diliyorum Işıl hocam… 😔
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Already 40 days without Alp 😔😔
He will never be forgotten.
May he rest in peace 🙏🏻🤍
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@ozlemyedier @wellcometrust @kocuniversity @tugbabagcionder @Tamer_Onder @berilesin_ @merdemercann @Tbo_Lab Tebrikler!
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I am extremely honored to receive @WellcomeTrust Early Career Award - the first-ever given to @kocuniversity and Türkiye 🇹🇷! Grateful to my mentors @tugbabagcionder and @Tamer_Onder.It was pleasure working w/@berilesin_ and excited for what’s ahead w/@merdemercann! #WellcomeTrust
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Caydasi Lab - Cell Cycle & Genome Stability ری ٹویٹ کیا
Department of Molecular Biology and Genetics at the Koç University College of Sciences is hiring tenure-track faculty!
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Grateful to Patricia M. Kane and @JCellBiol for highlighting our work.
Journal of Cell Biology@JCellBiol
Spotlight: Kane @UpstateNews discusses new work from @MaryHuda97 et al. @CaydasiLab (hubs.la/Q030lBmY0) showing that in S. cerevisiae transient cell cycle–dependent asymmetry in PI(3,5)P2 levels promotes vacuolar acidification in daughter cells. hubs.la/Q030lzJS0
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Caydasi Lab - Cell Cycle & Genome Stability ری ٹویٹ کیا
Spotlight: Kane @UpstateNews discusses new work from @MaryHuda97 et al. @CaydasiLab (hubs.la/Q030lBmY0) showing that in S. cerevisiae transient cell cycle–dependent asymmetry in PI(3,5)P2 levels promotes vacuolar acidification in daughter cells. hubs.la/Q030lzJS0
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Caydasi Lab - Cell Cycle & Genome Stability ری ٹویٹ کیا
🚨 Attention PhD students & postdocs! Last chance to apply for the FEBS Young Scientists’ Forum in Sapanca, Türkiye (2–5 July 2025). Present your research, network with peers, and learn from top scientists.
🗓 Apply by Dec 12, 23:59 (UTC+01:00). 2025.febscongress.org/ysf-applicatio…
#youngFEBS
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Català
Caydasi Lab - Cell Cycle & Genome Stability ری ٹویٹ کیا
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
biorxiv.org/content/10.110…
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Caydasi Lab - Cell Cycle & Genome Stability ری ٹویٹ کیا
@MaryHuda97 et al. @CaydasiLab @kocuniversity show that asymmetric PI(3,5)P2 synthesis is crucial for vacuolar-pH asymmetry and provide insights into how the mother cell ages while the daughter cell is rejuvenated in budding yeast hubs.la/Q02Xx8N70
#Mitosis #CellSignaling
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Job Alert! Our department, Department of Molecular Biology and Genetics at Koç University in Istanbul, has an open faculty position! Apply at academicjobsonline.org/ajo/jobs/29147
@kocuniversity @KocSciences
Eda Yildirim@YildirimLabDuke
🚨Job Alert 🚨 @KocSciences Department of Molecular Biology and Genetics is hiring tenure track faculty. The call is broad and many different fields of biology will be considered. Join an incredible Department with great colleagues here in beautiful Istanbul!
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We further showed that the asymmetry of PI(3,5)P2 and the PI(3,5)P2 effector Atg18 determine the asymmetry of vacuolar pH. Given the link between vacuole acidity and longevity, our results suggest that PI(3,5)P2 is key for daughter cell rejuvenation and mother cell aging.
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Employing a ratiometric in vivo vacuolar-pH sensor, we observed a pH drop in the daughter vacuole, while a pH increase in the mother vacuole, concomitant with changes in PI(3,5)P2 distribution during mitosis.
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I am excited to announce that our latest work is now published @JCellBiol! Huge congratulations to the co-authors @MaryHuda97 @KoyuncuMukadder @cansudilege. Big thanks to our funding bodies @Tubitak and @EMBO_YIP, @KocSciences, and to many labs who shared plasmid/strains with us.
Journal of Cell Biology@JCellBiol
@MaryHuda97 et al. @CaydasiLab @Kocuniversity reveal the dynamics of the vacuolar signaling lipid PI(3,5)P2 in budding yeast. PI(3,5)P2 synthesis is asymmetric during #mitosis and plays a key role in establishing vacuolar pH asymmetry. hubs.la/Q02Xx8N00 #Lipids
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