Dikic lab

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Dikic lab

Dikic lab

@DikicLab

Research group of @iDikic2 at @IBC2_GU. ubiquitination, autophagy, host-pathogen interactions

Frankfurt, Germany شامل ہوئے Ağustos 2020
80 فالونگ1.2K فالوورز
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PROXIDRUGS
PROXIDRUGS@proxidrugs·
🎙️Honored to enjoy insightful presentations on “RNA-based therapeutics” & “New targets & therapeutic approaches” on day 2 of the 1st Symposium on Advances in Therapeutic Approaches.🙏Thanks to all speakers & participants for their valuable contributions. @BMBF_Bund @HMWK_Hessen
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Dikic lab
Dikic lab@DikicLab·
🤩It's out! Check out our latest paper describing an optimised #CRBN that we used for high-throughput drug screening and developing new chemo-proteomic assays. #HTS #TPD @proxidrugs @IBC2_GU @goetheuni
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Cell Chemical Biology@CellChemBiol

Online! An engineered cereblon optimized for high throughput screening and molecular glue discovery by Henry Bailey, Jonathan Eisert, Fiona Sorrell @Fi_in_Frankfurt, Ivan Dikic @iDikic2 @DikicLab et al at @goetheuni @IBC2_GU @MPIBP @merckgroup dlvr.it/TGRCyX

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Dikic lab
Dikic lab@DikicLab·
*See, share, register* for the Frankfurt Conference on Quality Control in Life Processes, 24-27th of March. The speaker's lineup looks amazing already!! 🤩 👉Registration before 1st of December: fcqc.de #FCQC2025 #autophagy #proteostasis #ubiquitin
SFB 1177@sfb1177

Excited to announce the keynote speakers at #FCQC2025! Aaron Ciechanover from @TechnionLive and @dixitvishva from @genentech Stay tuned for more updates and don't forget to register!  fcqc.de #autophagy #ubiquitin #TPD #UPS #signaling

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SFB 1177
SFB 1177@sfb1177·
🔔 Registration deadline approaching! Don't miss out and secure your spot now! 🔗 fcqc.de #FCQC2025
SFB 1177@sfb1177

#FCQC2025: Registration open fcqc.de Join us for a high-caliber line-up of talks on quality control mechanisms & networks, the interplay of autophagy & ubiquitin in health & disease, novel therapeutics using the ubiquitin system. #proteostasis #autophagy

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Dikic lab
Dikic lab@DikicLab·
7th year in a row that Ivan is on the @Clarivate Highly Cited Researchers list. Congratulations @iDikic2 , and a big thank you to all the team members, past & current collaborators and colleagues. #HighlyCited2024 @ClarivateAG @goetheuni @IBC2_GU
IBC2@IBC2_GU

🥳 Proud to see IBC2 Director @iDikic2 on the #HighlyCited2024 list for the 7th year in a row! Congratulations to all @goetheuni colleagues on the list - @StefanieDimmel1, @HummerLab, Florian Greten, Sibylle Loibl & Stefan Offermanns

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Ivan Đikić
Ivan Đikić@iDikic2·
How changes in kinetics of #splicing can lead to proteotoxic cell death & what is the role of #ubiquitination and ER-phagy in this process? Congrats to Cristian & all collaborators for this fascinating discovery 👏 More info: x.com/IBC2_GU/status… #core-collateral-purchase-access" target="_blank" rel="nofollow noopener">science.org/doi/10.1126/sc…
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Cristian Prieto-Garcia@CristianPG_mlg

It is finally out! My first @ScienceMagazine paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor @iDikic2 for all the support and trust ! 🫶. Science science.org/doi/10.1126/sc…

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Dikic lab
Dikic lab@DikicLab·
Excited to share our latest research published in @ScienceMagazine! Cryptic splicing can lead to proteotoxic stress, but how do cells cope? Our study uncovers the role of ubiquitination and ER-phagy in mitigating the effects of misfolded proteins. science.org/doi/10.1126/sc…
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João Mello-Vieira
João Mello-Vieira@JT_MVieira·
I am very happy to have had the opportunity to present our latest results on targeting #legionella with #protacs. Especially in a session with such renowned scientists. Thanks to Antje Flieger and her team at @rki_de for organising this meeting.
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Cristian Prieto-Garcia
Cristian Prieto-Garcia@CristianPG_mlg·
Really happy to take part of this amazing manuscript from @crypt_tales and @DiefenbacherL published in @oncogenejournal . USP10 promotes colorectal cancer and stemness. #ubiquitin #cancerResearch 🫶👏🏻
Michaela Reissland@crypt_tales

🥳I am beyond to finally share the story of my PhD out now: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer nature.com/articles/s4138… Lets have a little look what we found: 🧵1/11

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Cristian Prieto-Garcia
Cristian Prieto-Garcia@CristianPG_mlg·
Really happy to contribute with mouse liver cancer models and human cancer data analyses to this amazing Cell paper from @iDikic2 and Herhaus lab. Huge congrats to Lina, Uxia, Ivan and other authors from @jwadeharperlab , @ManciasLab, @DikicLab, etc.👏🏻 sciencedirect.com/science/articl…
Cell@CellCellPress

Now online! IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion dlvr.it/TFvLRM

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Cell
Cell@CellCellPress·
Now online! IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion dlvr.it/TFvLRM
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Dikic lab
Dikic lab@DikicLab·
We identified IRGQ as a key regulator of MHC-I quality control. Its absence enhances CD8+ T cell responses. Reduced IRGQ levels in hepatocellular carcinoma patients and mouse models lead to improved survival by promoting anti-tumour immunity. #CancerResearch #Immunotherapy
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دریافت کریں

@bmbf_bund @HMWK_Hessen @proxidrugs @IBC2_GU @goetheuni @TechnionLive @dixitvishva @genentech