Mancias Lab

The Mancias Lab @DanaFarber is fighting #PancreaticCancer on #WorldPancreaticCancerDay #WPCD2017 #WPCD #PANCaware #DemandBetter @PanCAN

Excited to share our latest story @NatureComms. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors: #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

@Aiims1742 @nyulangone @Perlmutter_CC Congratulations!!

🤠 👉🏽 🗽 news: I will be joining @nyulangone on September 1, 2025 as Director of the GI Cancer Center & Associate Director of Translational Research at @Perlmutter_CC. I am excited to start the next chapter of the Maitra Lab in NYC & build a strong GI cancer research program.

How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/articl…

During the keynote addresses at #AACRpan24, Eileen M. O’Reilly and Joseph D. Mancias discussed how understanding pancreatic cancer’s strengths can help researchers uncover its weaknesses. Learn more on the #AACRBlog: bit.ly/47G1kQ9 @EileenMOReilly @ManciasLab

Joseph D. Mancias discussed "Targeting Autophagy in Pancreatic Cancer" in a Rising Star Keynote Lecture during the AACR Special Conference on Advances in Pancreatic Cancer Research. #AACRpan24 @ManciasLab

The (almost) full program is now online with an amazing lineup of speakers! #AACRPan24 @EileenMOReilly @ManciasLab @DrJashDatta @TeresaZimmers @DrHendifar @JanowitzTobias @wantong_yao @MaraShermanLab @KenOliveLab @andrewaguirremd @cjder23 @bryant_kl @pratt_ed @mggoggins @ChristieTowers @Cosimo_Commisso @Chiolaboratory @nada_kalaany and those not on Twitter. See you all in Boston! aacr.org/meeting/aacr-s… @AACR #PancreaticCancer

#AACRpan23 @graceah9 presenting her poster today - an awesome collaboration with @ManciasLab

WE ARE HIRING! We are looking for a motivated postdoc to work on a fully-funded project studying the role of iron metabolism in drug resistance in pancreatic cancer. 3 weeks left to apply. Please spread the word. au.dk/om/stillinger/… lnkd.in/eNgDM74z

@MuenchLab @Nature Awesome work, Christian and team!

I am happy to propose a model for mammalian #mitochondria UPR signaling, published @Nature. nature.com/articles/s4158… Mito protein misfolding induces two cytosolic signals –mtROS and mito protein precursor accumulation. These activate the mito UPR via a DNAJA1-HSF1 signaling axis.

@SantanaCodina @cancer_dk Congrats Naiara!

I am beyond excited to have been awarded a project grant by Danish Cancer Society @cancer_dk to work on iron metabolism in PDAC! This is a huge step as a new PI that will help stablish the lab. Grateful to mentors,colleagues and family. I will be hiring postdocs soon,stay tuned!

@JEncarnacion_ Congrats Joel! Great work!

So happy to see our manuscript finally out!! science.org/doi/10.1126/sc…

Our #OpenAccess review on #PancreaticCancer - advances & challenges is now online at @CellCellPress Many thanks to @CJHPhD @Pasca_Lab & @LyssiotisLab for all the hard work & @jiaying_tan6 for the opportunity. It’s FREE to read so share widely! cell.com/cell/fulltext/…

We are so inspired by patients like Candace and her experience. With a loving and supportive family and the latest treatments at @DanaFarber, Candace is a source of hope for more patients with pancreatic cancer. blog.dana-farber.org/insight/2023/0…

Researchers at @DanaFarber and other institutions recently made important discoveries into the recycling system of pancreatic cancer cells, a promising step toward targeted therapies for one of the most challenging cancers. blog.dana-farber.org/insight/2022/1…

Pancreatic cancer cells operate a recycling program that would be the envy of any municipality — but the only beneficiaries are the cells themselves. blog.dana-farber.org/insight/2022/1…

A cross-country collaboration between former Damon Runyon-Rachleff Innovators @rushika_perera and @ManciasLab uncovered another way that #PancreaticCancer evades targeted therapies – and a new potential therapeutic target: bit.ly/3uQwFgd

Latest Wolpin-Nowak lab paper on single cell, in situ protein-based characterization of transcriptional subtypes in pancreatic cancer now out in @CR_AACR aacrjournals.org/cancerres/arti…

Now online in @CD_AACR: Targeting UGCG Overcomes Resistance to Lysosomal #Autophagy Inhibition by Vaibhav Jain, David Speicher, @AmaravadiRavi and colleagues @TheWistar @PennCancer aacrjournals.org/cancerdiscover…

Robert Hale's determination in @DanaFarber and the Hale Family's incredible generosity help drive @DanaFarber_Hale closer to a cure for pancreatic cancer. forbes.com/video/63128816…

@mouwlab @theNCI @BrighamRadOnc @DanaFarber Congratulations!!!

Grateful to NCI @thenci, lab members @mouwlab, department @BrighamRadOnc @danafarber, mentors, and collaborators for this opportunity to study DNA repair to advance bladder sparing treatment for MIBC!