Zachary Sanchez

Happy Pride Y’all! I wanted to make sure some incredible LGBTQ+ people that have contributed to science are recognized like Ben Barres, Sara Josephine Baker, Sally Ride, and Alan Turing. Much love and appreciation to all current LGBTQ+ scientists as well!

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

Unleashing live-cell imaging for the masses! This is MEGA-exciting!!! Adapting the OpenFlexure Microscope for Affordable Live-Cell Imaging biorxiv.org/content/10.648… This can fit into existing incubators and capture time-lapse experiments and feeds into existing bioimaging analysis pipelines. Thanks @wellcometrust for funding

Isadonna Tengganu and Ke Hu develop transfection and ExM protocols for Chromera velia, enabling direct comparisons with its parasitic apicomplexan relative, Toxoplasma gondi. journals.biologists.com/jcs/article/13…

Happy #fluorescencefriday ! Haven’t done one of these in a while, but wanted to share what I’ve been working with in my new post doc! Below is an expansion microscopy image of Toxoplasma gondii stained for microtubules. #microscopy #fluorescence #toxoplasma

Burnette Lab paper: "Pharmacological Inhibition of β Myosin II Disrupts Sarcomere Assembly in Human iPSC-Derived Cardiac Myocytes" is out! This image is of beta myosin II filaments in an iPSC-derived cardiac myocyte. #CellBiology onlinelibrary.wiley.com/doi/10.1002/cm…

"Non-Muscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling" is now online at Circulation Research! Congratulations to Dr. James Hayes on this ambitious work! There is a lot in the paper so let's start with the graphical abstract. @CircRes ahajournals.org/doi/10.1161/CI…

Next-generation orange-to-far-red photoconvertible fluorescent protein for single-molecule microscopy and protein dynamic tracking Oksana M. Subach, et al. doi.org/10.1038/s41598…

A hungry heart muscle cell (cardiac myocyte) videoed through a microscope by Burnette Lab graduate student, @EmmaKoory. What is it eating and why? We may never know....... #CellBiology

A cell with prominent membrane blebs videoed using spinning disk confocal (left) and differential interference contrast (right) microscopy. #CellBiology

Felix Zhou's-Segment3D is out: nature.com/articles/s4159… It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation. It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.

Been doing a lot of time lapses of iPSC-derived cardiac muscle cells lately! Here's one of my favorites. This cell is expressing fluorescent alpha-actinin-2 and the colors represent depth. Movie length = 24h with frames taken every 20m. #microscopymonday #cellbiology @MAG2ART

iPS cell-derived cardiac myocytes (heart muscle cells) typically beat about once per second, so I usually speed up the movies I post; otherwise, scrollers might miss the action. But every now and then, a cell looks like this in real time. Could we use these rare cells to uncover mechanisms underlying arrhythmias? Probably, but the way the Burnette Lab would approach that would require a lot of description-- I apologize for using such filthy language. Description indeed...... Grant reviewers hate the uncertainty that word implies; "What if they just take a bunch of videos with their microscopes?" Well, we would do that....... and some other stuff...... the idea that we would not discover something new along the way is laughable. The "other stuff" would be pretty cool. This video shows an iPSC-derived cardiac myocyte videoed by Burnette Lab graduate student @EmmaKoory. Muscle myosin II is shown. #CellBiology

Extremely happy to share this: our work is the first high resolution atlas of cytoskeletal diversity using UExM is out in Cell!! Together with F.Mikus and @HiralABShah 🥳🥳 cell.com/cell/fulltext/… Amazing collaboration between CentrioleLab, @dudin_o and @Dey_Gautam

Cells and blebbisomes photographed through a microscope by Burnette Lab graduate student, Grace Ward. Actin filaments are shown. #CellBiology

The Burnette Lab did well this year in the Nikon Small World contest this year! Way to go James and Zach! 🔬 nikonsmallworld.com/galleries/2025…

It's the moment weeviI been waiting for! 🏆 🥇 Congratulations to Zhang You, 1st place winner of the 2025 Nikon Small World competition, whose detailed close-up brings us face to face with a rice weevil. 🔗 Check out the entire gallery, now live at: nikonsmallworld.com/galleries/2025…

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues. biorxiv.org/content/10.110…

@kWolbachia Awesome work! Will for sure test it out

I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager! I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-for-…

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing 🔵 Lifeact & 🔴 RFP-nls Honored & grateful to receive an honorable mention at @NikonInst Nikon Small World 🌍🔬✨ 🔗 nikonsmallworld.com/galleries/2025… #NikonSmallWorld #Microscopy #ScienceArt

Highly efficient 12-color multiplexing with speed-optimized DNA-PAINT. We are excited to share our latest publication in @NatureComms, using left-handed DNA to extend speed-optimized DNA-PAINT to 12 targets in a simple and straightforward way! 🧬👈🚀nature.com/articles/s4146…