Lain Nail

753 posts

Lain Nail

Lain Nail

@LainEsper

I'm a yapper. I'm sorry. Lo que no mata engorda.

شامل ہوئے Şubat 2026
275 فالونگ56 فالوورز
Lain Nail
Lain Nail@LainEsper·
@Iberianamerica I've never heard that stereotype before. What I've seen on Twitter is that single mothers who had a mixed child with a black father are considered low quality.
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Iberian America
Iberian America@Iberianamerica·
Latina ponders an important question: "Why do men refuse to date women who dated Black guys?"
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Lain Nail
Lain Nail@LainEsper·
@bryan_johnson Your willingness to abuse yourself for the benefit of mankind is amazing. I mean it. If I had your money, I'd abuse myself but only to benefit myself.
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Lain Nail
Lain Nail@LainEsper·
@bryan_johnson So basically the mushrooms made your sperm terrible swimmers? Am I understanding that right?
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Bryan Johnson
Bryan Johnson@bryan_johnson·
Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.
Bryan Johnson tweet mediaBryan Johnson tweet media
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Errai
Errai@errai·
When I was in high school I asked my chemistry teacher "what makes salt so unique?" and she replied "it tastes salty" and to this day I remember thinking man just say you don't know
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Lain Nail
Lain Nail@LainEsper·
@entertheunseen I think you're in the wrong universe if you think flesh and reverence belong in the same sentence. Mankind is just meat with delusions of grandeur.
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GINA NÄUMAN • جینا نعمان
The nude female form is one of the closest things to angelic beauty on this Earth. Problem is, too many men cannot be trusted to gaze upon the female form with reverence. They’ve absolutely & utterly ruined the act of devotional appraisal. Most men don’t deserve to look at women.
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Lain Nail
Lain Nail@LainEsper·
@MelissaTitanium I'm sure there used to be. I could imagine "heathen" being directed mostly to men and possibly being dangerous in more religious times.
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nelson . ΘΔ
nelson . ΘΔ@MelissaTitanium·
i am constantly thinking about it passively but it does dawn on me every couple of weeks that in english at least there really isn't any profanity i can think of that are directed specifically towards men. be a pussy (weak), have balls (strong), bastard (lack of male figure in
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Siavoush Fallahi
Siavoush Fallahi@SiavoushF·
As long as technical football >> physical garbage football, football is safe
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Lain Nail
Lain Nail@LainEsper·
@MessiFanatic_ Berterame can't be the starter. He simply hasn't earned it. I know he's the big purchase but you need to score to win games and he can't.
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Messi Fanatic
Messi Fanatic@MessiFanatic_·
What Mascherano needs to do is use Messi as a false 9 and have Allende and Silvetti make runs behind the opposition's backline. That's how Inter Miami won MLS Trophy last season. But Mascherano has completely abandoned this idea since Berterame arrived, and it's not working.
Messi Fanatic tweet media
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Wiener Dog 🇵🇸
Wiener Dog 🇵🇸@MoroseJerk·
I genuinely thought they meant he shit himself what the fuck is wrong with me
Wiener Dog 🇵🇸 tweet media
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Lain Nail
Lain Nail@LainEsper·
@cremieuxrecueil Would this have been visible on black people or did it disappear before black people existed?
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Crémieux
Crémieux@cremieuxrecueil·
Everyone has stripes known as Blaschko's lines. These are normally not visible and are generally only present if there's an issue, chimerism, etc. But some birds can see them!
Crémieux tweet media
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Lain Nail
Lain Nail@LainEsper·
@MoiraDonegan The Muslims were right in a way. Separate the sexes. Men can't be trusted around women and women can't be trusted to defend themselves.
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Moira Donegan
Moira Donegan@MoiraDonegan·
Right wing men desire a world ruled by hierarchy and domination, and the way they treat women and girls is an extension of that principle. Left wing men desire a world ruled by equality and dignity, and the way they treat women and girls is an exception to that principle.
Shane Goldmacher@ShaneGoldmacher

MUST READ: A bombshell NYT investigation shows that Cesar Chavez sexually abused young girls. Dolores Huerta also discloses for first time that that Chavez raped her. So much more from Manny Fernandez and Sarah Hurtes —> nytimes.com/2026/03/18/us/…

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Lain Nail
Lain Nail@LainEsper·
@ErrolTostigson It's never the best-sounding accents that become dominant. Unfortunately.
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Эррол Хан
Эррол Хан@ErrolTostigson·
It’s obvious when you meet younger people from around the English world that a universal internet Americans accent is beginning to form from the content kids watch. Is something similar happening with other languages like French or Spanish?
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Lain Nail
Lain Nail@LainEsper·
@TJayyyy_1 It's gotta be soul-shattering as an athlete because you're not some 80 yr old who shits himself every time he farts. You're still in the prime of your youth and yet you've become obsolete.
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Lain Nail
Lain Nail@LainEsper·
The Philadelphia union just lacks the quality in attack to punish a nervous Club America defense.
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Lain Nail
Lain Nail@LainEsper·
@MLSMoves They'd do fine in the Sudamericana though. In fact, that's probably the level where some MLS teams probably surprise a lot of people with their own quality.
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MLS Moves
MLS Moves@MLSMoves·
If Inter Miami got bounced in the round of 16 in CCC, imagine what would happen to them in Copa Libertadores.
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Lain Nail
Lain Nail@LainEsper·
@JoserNunez91 A cavan Sullivan game-winning goal would be the cherry on top.
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José Roberto Nuñez
José Roberto Nuñez@JoserNunez91·
Immediate impact by Westfield, giving this team life by making a run that Bueno finds, leading to a foul that earned Philadelphia a penalty kick. Bueno conversts it. Game on (?). #doop #MLS #ligamx #concacaf #clubamerica 📹: CONCACAF Youtube
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Lain Nail
Lain Nail@LainEsper·
@CrashoutWanis @MLSMoves You can use them as results if you want. I struggle to take leagues cup results against Liga MX teams as predictors for the CCC. You guys definitely beat Philly if they beat America though.
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MLS Moves
MLS Moves@MLSMoves·
Congrats to Nashville SC on the historic win! Go beat Club America!
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