Raphael Lis

🚨Our updated bioRxiv preprint is now online! Using whole-slide multiplex immunofluorescence and single-cell spatial analysis, we map bone marrow architecture in MDS across millions of cells. Preprint: biorxiv.org/content/10.110… #MDSsm #SpatialBiology #DigitalPathology

The Koh Lab (medicine.yale.edu/profile/bongih…) is hiring!! Please reach out to join our newly established lab (now with an amazing graduate student and a very talented undergraduate student) as a Postdoctoral Fellow/Associate! Come help us write the first exciting chapter of our saga!

Excited to share that my PhD work on ER mito contact sites is finally out at @MolecularCell! Big shout out to @stark2_d to take this across the finish line, and @YatrikShahLab and @LyssiotisLab for their guidance as always!

I am excited to share our latest research out today @NatureGenet; here we discovered childhood brain tumours instruct cranial hematopoiesis and identify a clinically relevant mechanism to re-educate the skull bone marrow. nature.com/articles/s4158…

@LyssiotisLab Amazing. Please send ral2020@med.cornell.edu

I have been instructed on hacks to making the formatting more palatable! Too much to type here, DM and I’ll send the slide deck from Michigan Medicine IT 💪🏼

Mind blowing. @insitubiology A genetically encoded device for transcriptome storage in mammalian cells | Science science.org/doi/10.1126/sc…

Great postdoc opportunity in the Christer Betsholtz group at Uppsala University, led together with Riikka Pietilä. Fantastic science and environment - please share!

Extremely excited to share my first first-author publication posted today in @nature, a joint effort with co-first author @wenzhang1120 ! Here, we identify a novel neuronal-epithelial circuit as a critical determinant of type 2 immunity. nature.com/articles/s4158…

Truly elegant paper from @PaquetLab published in @NatureNeuro. Congratulations. nature.com/articles/s4159…

journals.physiology.org/doi/abs/10.115… Not the final version...but first one (though a review) with my new affiliation! Many thanks to @ralfhadams for the phenomenal support!!

Finally - It is official. Thank you @atvbahajournals for highlighting the amazing work of Aomeng Cui in the @AgalliuLab and Sproul labs to generate IPSC-derived human brain endothelial cells and build a 3D iPSC - derived neurovascular unit for studying neurological diseases.

🔬 We have an opening for a postdoctoral fellow in my lab at Weill Cornell in NYC. This position is ideal for a rigorous, hands-on experimental biologist who loves designing and executing complex wet lab experiments. The focus is on mechanistic cancer biology in cell lines and patient-derived models, with genomics and AI tools integrating with the core bench work. Details below. 👉 Please share with strong experimental candidates in your network. #Postdoc #PostdocJobs #AcademicJobs #CancerResearch #MolecularBiology #WetLab #ScienceCareers #AcademicTwitter

An innovative approach of reprogramming stomach cells to produce insulin that are functional in vivo cell.com/stem-cell-repo…

Dr. Cesi Deng and team at the Tamplin lab report GABA metabolite by B cells and endothelial cells in the bone marrow as a regulator of hematopoietic stem and progenitor cells. 🧫 bit.ly/4qoFauz | @stemcellreports

In a project led by Rory Long, we developed a 3D brain microvessel coverage that recapitulate physiology pericyte coverage. We found that malaria products halt angiopoietin secretion by pricytes, a vascular protective molecule. We could rescue barrier disruption with AKB-9778!

A postdoc position is open in the @AgalliuLab for a scientist with a strong PhD background in Neuroscience, Neuroimmunology or Vascular Biology and interest in neurovascular / BBdysfunction in CNS disorders. Please contact me with your CV and cover letter if you are interested.

Intussusceptive angiogenesis: bridging in vivo and in vitro observations link.springer.com/article/10.100… Thanks, Dr. Steven Mentzer and Dr. Maximilian Ackermann🙏 for this insightful highlight of our recent @PNASNews paper on #IntussusceptiveAngiogenesis😁 Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination pnas.org/doi/abs/10.107…

Congrats to my postdoc, Aya Ludin Tal, on her Cell paper. Her work using live imaging in zebrafish identifies CRATERS on the surface of melanoma - immune hubs for T cells. CRATERS in human melanoma are the best predictors of immunotherapy success. authors.elsevier.com/sd/article/S00…

Human brain vascular multi-omics elucidates disease-risk associations. Read the full study led by @andcyang @GladstoneInst @UCSF in @NeuroCellPress #ASHG25 hubs.li/Q03NybYp0

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story led by Frederick Rehfeld revealing that the answer is YES! Read on to find out how. biorxiv.org/content/10.110…