Lyssiotis Lab

🚨New @LyssiotisLab paper led by Dr. Megan Radyk in @NatureMetabolism "NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions" 🧵Follow for a tweetorial... and bonus highlight of @LabVousden co-published study and News & Views link from @WellenLab!

Learn how daraxonrasib, one of the first major breakthroughs in pancreatic cancer treatment in years, could help reshape the future of care. Hear from @LyssiotisLab about what the discovery means for patients and ongoing research.

In @embojournal from @KalluriLab & @mcandrews_kate @UTMDAnderson dissecting a novel mechanism of resistance to KRAS inhibitors: CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in #PancreaticCancer link.springer.com/article/10.103…

@EricTopol @CharlesMBrenner @grok the waves of molecular aging might be statistical artifacts: biorxiv.org/content/10.648…

@cholsoon_jang Congrats! Take a few more minutes to relish the important (and deserved) milestone 💪🏼

Got tenured! Felt a bit relieved for a day, then went back to writing grants again.

Just paid $480 for my yearly faculty parking pass, so I once again have to say that it is such a scam to have to pay to park at your job.

The TEAM! #pancconf26

A new study by a team at the @UMich has the potential to accelerate efforts to better understand the neurobiology that underlies behavior and decision-making in mammals, including humans. myumi.ch/8J5NZ

🧵 Check out our new paper in @NatureMetabolism: rdcu.be/fsLXJ! Hypoxia rescues a mitochondrial proteostasis disease, extending our hypoxia therapy program beyond primary Complex I disease. Stay tuned for more July preprints! And we are still hiring stellar postdocs!

A potential drug developed at @umichmedicine treats severe fatty liver disease by improving gut health, per a study published in @jclinicalinvest. DT-109, reversed MASH in animal models by disrupting a disease-driving pathway that links the gut & liver. michiganmedicine.org/health-lab/dru…

Can dementia be prevented with lifestyle improvement and attention to risk factors? feature @Nature by @hcpearson nature.com/articles/d4158…

Happy to share our new preprint from @RutterLab. To understand how genes are controlled, we developed a method we call TRoUT-FISH, using CRISPR + RNA-FISH. We found that glycolytic gene expression is fine-tuned by lineage specifying transcription factors. biorxiv.org/content/10.648…

Excited to share our Review in @NatureCellBio with my student @DohunKim96 ! We highlight how nucleotide metabolism is dynamically regulated in physiology and how disruption of this control contributes to human disease. nature.com/articles/s4155…

Excited to share our new preprint from @RutterLab, identifying a melanosomal tyrosine transporter! biorxiv.org/content/10.648…

There is lots more happening in London outside of futbol. Members of the Rogel and Blondy Center research team are presenting this week at the Cancer Research UK Pancreatic Cancer Conference 2026. #pancconf26 @timofran1 @Pasca_Lab @ABischoff17 @RashmiJKumar @Fil_Bednar @UMichSurgery

Highlighting Dr. Eileen Carpenter in San Diego. Rising Star Keynote Speaker on September 25th! Wired for innervation: Modeling the neural niche in PDAC . Check out the AACR program and plan to register: brnw.ch/21x3K6A #AACRpan26 @Pasca_Lab @timofran1 @LyssiotisLab @UMRogelCancer

@lia_lian_liang @CrohnsColitisFn @YatrikShahLab @KoutmosLab Fantastic news!! Congrats 🎉

Honored to receive a @CrohnsColitisFn Research Fellowship Award to study how tRNA biology shapes epithelial repair in IBD. Many thanks to @YatrikShahLab @LyssiotisLab @KoutmosLab and Spence lab for their support.

From @RevMedicines data on Zoldonrasib plus Daraxonrasib in 2nd & 3rd line metastatic #PancreaticCancer - presented at #ESMOGI26 Small numbers but even a few years back, who would have imagined survival curves like this in 2nd & 3rd line metastatic PANCREATIC cancer? Amazing!

A sight for sore eyes! Happy to have @RevMedicines Daraxonrasib available for our patients now under the @US_FDA expanded access program. Huge thanks to @md_oberstein & @Perlmutter_CC clinical trials office for all the hard work that went into getting this done in record time.

An honor to co-launch with @tomas_pluskal the Dream Biology Award for young researchers (7 years from PhD) that comes with a €10,000 prize and trophy. dreambiologyaward.org stellar committee: dreambiologyaward.org/committees Deadline July 31, 2026.

Thrilled to share the 1st cancer paper out of our lab @Cancer_Cell !😀@hilalbashir65 @WeillCornell We show chronic stress drives translocation of gut bacteria w lytic phages to tumors&unleashes an phage-fibroblast-B cell circuit to promote tumor growth sciencedirect.com/science/articl…