Fischer Lab

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Fischer Lab

Fischer Lab

@fischerlab1

News and updates from the Eric Fischer Lab, Est. Oct 2015 @DanaFarber @harvardmed | E3 Ligases | Ubiquitin | Degraders | Chemical Biology | Cancer

Boston, MA شامل ہوئے Mayıs 2018
53 فالونگ2K فالوورز
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Katherine A Donovan
Katherine A Donovan@kdonovan1008·
🧩 New paper out in Nature Communications! "Unveiling the hidden interactome of CRBN molecular glues" Huge thanks to our incredible team and collaborators who made this possible! 📖 Read the full open-access article here: nature.com/articles/s4146…
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Michael Erb
Michael Erb@Michael_A_Erb·
We keep stumbling on molecular glues, but how can they be made for a pre-selected target? We’ve been working on this question, envisioning a high-throughput chemistry (HTC)-based approach to convert pre-existing ligands into molecular glues. biorxiv.org/content/10.110…
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Jiho Park
Jiho Park@jihojasonpark·
Excited to share our story on polymerization in ZBTB transcription factors, which was published in the July 11 issue of @MolecularCell! cell.com/molecular-cell… 1/n
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Katherine A Donovan
Katherine A Donovan@kdonovan1008·
We are looking for a couple of Research Technicians to join us in the @fischerlab1! If you enjoy biochemistry/chem bio and are interested in working in a great team exploring degrader induced interactions and degradation reach out or apply: careers.dana-farber.org/job/research-t… Please RT!
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Hubert Huang
Hubert Huang@hai_tsang_huang·
Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) @nchembio! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/ rdcu.be/dBZKx
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Fischer Lab
Fischer Lab@fischerlab1·
Great to see this story out - congrats to the team 🎉
David R. Liu@davidrliu

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology. PDF: drive.google.com/file/d/18hu15h… 1/13

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Lyn Jones
Lyn Jones@LynJonesChemBio·
We are looking for a postdoctoral research fellow to work with Eric Fischer and myself to pioneer next-generation covalent drug discovery. Please retweet. Apply here: careers.dana-farber.org/jobs/?search_t… @fischerlab1
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Fischer Lab
Fischer Lab@fischerlab1·
Another incredibly fun @HMS_BCMP retreat - we decided to become the UPS this year!!
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Fischer Lab
Fischer Lab@fischerlab1·
Don’t miss out on attending the Keystone Targeted Protein Degradation and Proximity Therapeutics, January 21-24, 2024 🧬⛷️👩‍💻 Abstract deadline is October 26. Targeted Protein Degradation  lnkd.in/erkd5Yt4 Proximity Based Therapeutics lnkd.in/evkF59ga
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Katherine A Donovan
Katherine A Donovan@kdonovan1008·
This week in the TPD seminars we are hosting two excellent speakers @KheewoongBaek and @LukasHenneberg sharing stories from work completed in Prof. Brenda Schulman's lab at Max Planck Institute for Biochemistry ! See you at 11am EST!!!
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