Wallace Wang

@MinSeoKim_MD @Cell_Metabolism THANKS MUCH Min Seo and THE WHOLE TEAM!🌹🌹🌹🌹

🎉Excited to share our new research published in @Cell_Metabolism on the metabolic polygenic risk score To date, polygenic risk scores (PRS) have been developed and validated against single traits. In this study, we generated a PRS that captures metabolic dysfunction. Key take-aways: 👉 Biologically enriched Metabolic PRS was developed from GWAS of 20 metabolic traits 👉 Metabolic PRS demonstrated superior obesity & diabetes prediction across six ancestries 👉 Beyond predicting future risk of obesity and type 2 diabetes, Metabolic PRS effectively identified individuals at high risk for metabolic multimorbidity, and even likelihood of requiring GLP-1 receptor agonist & bariatric surgery, which proxy the clinical severity of metabolic dysfunction Huge thanks to co-first Qiuli Chen & Yang Sui, and co-seniors @aklfahed, @patrick_ellinor, and Minxian Wang who made this project possible! Deep appreciation to every contributor who helped bring this together: @LuChenWeng, @somijemmacho, @skoyamamd, @pnatarajanmd, and many more! Paper: lnkd.in/esdKX_N5 Support of @MGBResearchNews @MGHMedicine @mghcvrc @broadinstitute

Great opportunity 👍👍

🧬 Calling all GWAS + integrative analysis researchers! 🔎 Come explore the PEGASUS Framework, a FAIR community standard for predicted effector genes, at our Knowledge Portal Webinar with @GWASCatalog ⏰ Dec 11, 2025 | 12-1 PM ET 🔗ebispot.github.io/PEGASUS/

@ZhiYu_ACGT @jsdron Huge congratulations 🎉 🎉 @jsdron

Huge congratulations to our marvelous @jsdron🎉 so well-deserved!

Very cool work now out in @JAMACardio - common, rare, and somatic genetic variants provide complementary information (beyond clinical risk factors) for stratifying future #afib risk. Implications for risk-guided prevention and screening @MGHHeartHealth @broadinstitute

@pnatarajanmd @aklfahed @JAMACardio @MGBResearchNews @broadinstitute @harvardmed @patrick_ellinor @MinSeoKim_MD @shaan_khurshid @MGHHeartHealth @mghcvrc @CGM_MGH Thank you very much @pnatarajanmd, it's a great pleasure working with you! - Wallace

Our study, from @aklfahed @wallacemwang labs, shows that a multi-genomic (polygenic, monogenic, somatic) risk model improves incident atrial fibrillation risk prediction when added to a clinical risk score (CHARGE-AF) jamanetwork.com/journals/jamac… @JAMACardio

@skoyamamd @MassGeneralCVRC @harvardmed @broadinstitute @MGBResearchNews @mghcvrc Huge congratulations @skoyamamd !!!

Excited to share that I am launching my Computational Genetics Lab spanning Mass General Brigham Personalized Medicine (MGB-PM), @MassGeneralCVRC , @harvardmed and @broadinstitute! Our lab will focus on genetics 🧬 in common diseases focusing on cardiovascular diseases🫀

🧵1/ Delighted to announce our new study: Machine learning-based penetrance of genetic variants by @IainSForrest et al. published in @ScienceMagazine! Paper: science.org/doi/10.1126/sc… Press release: mountsinai.org/about/newsroom… @AIHealthMtSinai @SinaiGenetics

🚨 Big news from @SusztakLab! Our paper is out in @NatureGenet: "From Million-Cell Atlases to One-Patient Reports" 🧬🧑‍⚕️Together with biostats wizard @NancyRZhang and physician-scientist trainee @KonstantinKltz, we built a cross-species single-cell kidney atlas and analytics engine: 🔗 nature.com/articles/s4158…

Longdust, a new tool to identify highly repetitive STRs, VNTRs, satellite DNA and other low-complexity regions (LCRs). Similar to SDUST but for long regions. github.com/lh3/longdust

Motivated by the favorable lipid indices and CV risk of ANGPLT3 & ANGPTL8 LoF carriers, @EliLillyandCo developed a combo ANGPTL3/8 mAb (LY3475766). Phase 1 RCT shows that LY3475766 recapitulates lipid patterns from human genetics nature.com/articles/s4159… @NatureMedicine @Giacomo_Ruotolo HDL-C effects more reflective of ANGPTL8 LoF (high) than ANGPTL3 LoF (low). Nice commentary from @ArchnaBajajMD & D. Rader nature.com/articles/s4159…

🚨 Excited to share our new manuscript in @circAHA led by @BellomoTiffany and team. We evaluated lipoprotein(a) as a prognostic marker for extracoronary atherosclerotic vascular disease progression in @uk_biobank. 👉 doi.org/10.1161/CIRCUL… 🧵1/6

Two new papers in @NatureGenet from @patrick_ellinor and team Expanding genetic discovery of rare, structural and common variation in atrial fibrillation Sequencing >50K cases nature.com/articles/s4158… GWAS >180K cases nature.com/articles/s4158…

@pnatarajanmd @JAMA_current Huge congrats!!!🎉 🎉 🎉

Very excited to join the @JAMA_current team & contribute to the field of cardiology in this new way! As a reader, author, peer reviewer, and editor, I am deeply invested in the process of producing & communicating high-quality biomedical research. I will deeply miss regularly interfacing with my all-star editorial colleagues at @JAMACardio & @ScienceAdvances. @MassGeneralNews @broadinstitute @harvardmed

NEW in @Circ_Gen led by @tigerstatdoc Genomic and clinical risk factors of CAD display time-varying importance over the life course. The importance of CAD PRS is highest earlier in life and diminishes with older age. Collab with @pnatarajanmd @MGHHeartHealth @mghcvrc @broadinstitute ahajournals.org/doi/10.1161/CI…

NEW preprint led by @MinSeoKim_MD @Alisa_QiuliChen and Yang Sui Metabolic Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related Morbidities O-MetPRS and D-MetPRS 🔹 Leverage 22 metabolic traits from over 10 million people 🔹Derived in UKB, validated in All of Us, MGB Biobank and KFSH&RC 🔹Outperform existing PRSs in 6 ancestry groups 🔹Predict numerous morbidities of diabesity 🔹Predict prescription of GLP1 receptor agonists even among people without obesity at baseline Collaboration with @wallacemwang @patrick_ellinor @broadinstitute @MGHHeartHealth @mghcvrc Manuscript here medrxiv.org/content/10.110… X-planation from @MinSeoKim_MD below

@aklfahed @MinSeoKim_MD @pnatarajanmd @broadinstitute Thanks very much to all the incredible collaborators! 🎉🎉🌹🌹

NEW from @MinSeoKim_MD and Xiong Yang An Integrated Germline and Somatic Genomic Model Improves Risk Prediction for Coronary Artery Disease medrxiv.org/content/10.110… Awesome collaboration with @wallacemwang @pnatarajanmd and enabled by UKBB and TOPMed @broadinstitute @MGHHeartHealth @mghcvrc Thread below

@jpirruccello @Microsoft @onedrive 😭😭😭😭