Geoff Faulkner

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Geoff Faulkner

Geoff Faulkner

@Faulkner_Lab

Professor, University of Queensland. Retrotransposons and genomics. Views my own. Scholar publications: https://t.co/xQu0hWudj1 @faulknerlab.bsky.social

Brisbane, Queensland Tham gia Temmuz 2017
293 Đang theo dõi2.8K Người theo dõi
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Geoff Faulkner
Geoff Faulkner@Faulkner_Lab·
After years of telling visitors to Brisbane what an awesome place it is for fun* adventures, I've decided to make a list in the order I remember them of my favourite places to go for ease of reference. Here goes ... (*definition of fun may vary)
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Marco_Trizzino Lab
Marco_Trizzino Lab@marcotrizzino·
1st submission (2019): ND A1: 26th % A0: 24% A1: 22% A0: 17% A1: 3% For this R01 it took 5 years and 6 submissions but persistence pays off, especially if you have amazing collaborators like @BrugmannLab and Kevin Peterson. Some amazing neural crest science coming up!
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Johan Jakobsson
Johan Jakobsson@JakobssonLab·
@Faulkner_Lab @Dev_Cell Indeed. We discussed this preprint at our JC recently. We have the same questions and concerns. We also don't understand this...
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Geoff Faulkner
Geoff Faulkner@Faulkner_Lab·
Reposting comment on preprint of this @Dev_Cell paper. Stats done on technical replicates of L1 KD to make small absolute changes seem significant. Biological replicates were available but not used for stats, why? Because p>0.05? I don't understand this. sciencedirect.com/science/articl…
Geoff Faulkner@Faulkner_Lab

I doubt the stated phenotype here is due to changes in L1 mRNA. The ASO and CRISPRi KD approaches (Figs 1, S1, S2) reduce L1 expression by <10% and these small changes are noted as efficient and significant KD. Stats were done on tech reps to give p<0.05 biorxiv.org/content/10.110…

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Geoff Faulkner
Geoff Faulkner@Faulkner_Lab·
@PRAndersen @RippeiH More interesting reading here and food for thought too, thanks. Also, as per Maslow's hammer, a lot of these systems likely evolved to control transposons in some way but now work somewhat differently on genes.
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Peter Andersen
Peter Andersen@PRAndersen·
@Faulkner_Lab @RippeiH 3/ Examples: Specific TFs => Integrator recr. (PMID: 38906142) snRNA promoters (SNAPc) guide 3' processing (e.g. PMID: 3021336) Heterochromatin-dep transcription (PMID: 28847004) + good overview of other ex here: PMID: 23337853
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Peter Andersen
Peter Andersen@PRAndersen·
1/ Our lab’s first preprint found a wonderful journal home! 🎉 Our paper explores the role of testis-specific transcription factors in Drosophila and reveals broad functional connections between tissue-specific paralog proteins. 📝: genesdev.cshlp.org/content/early/…
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Centre for Genomic Regulation (CRG)
Centre for Genomic Regulation (CRG)@CRGenomica·
🚀 Join the CRG as a Junior Group Leader in Quantitative Cell Biology! 🧬 We’re seeking passionate leaders to tackle fundamental biological questions using cutting-edge multidisciplinary approaches. Enjoy generous core funding, state-of-the-art facilities, and a collaborative environment. 📅Apply by Oct 15! ℹ️Details: ow.ly/aACB50TzKM2 #CRG
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Marco_Trizzino Lab
Marco_Trizzino Lab@marcotrizzino·
The 5-year postdoc position in my lab is now "live" for applications! Deadline to apply is November 3rd: imperial.ac.uk/jobs/search-jo… Please RT
Marco_Trizzino Lab@marcotrizzino

Our collaborative NIH-R01 to study the role of TEs in ALS was awarded today, in collaboration with Davide Trotti and Piera Pasinelli (ALS Center at Thomas Jefferson University). Our lab in London will soon advertise a 5-year postdoc position. Please reach out if interested!

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Geoff Faulkner
Geoff Faulkner@Faulkner_Lab·
I doubt the stated phenotype here is due to changes in L1 mRNA. The ASO and CRISPRi KD approaches (Figs 1, S1, S2) reduce L1 expression by <10% and these small changes are noted as efficient and significant KD. Stats were done on tech reps to give p<0.05 biorxiv.org/content/10.110…
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Geoff Faulkner
Geoff Faulkner@Faulkner_Lab·
@MRSantosLab Hi Miguel I have some questions: In Fig 1D, S2A and S2E what is each data point? A cell? What is the absolute change in L1Hs expression caused by the ASO or CRISPRi? In Fig S2C what is the mean value for each of the 3 groups, instead of Z-score? Thanks.
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Charlie Bell
Charlie Bell@charles_bell92·
I am looking for a motivated PhD student who is interested in understanding the fundamentals of gene regulation. They will be working directly with me on a DECRA funded project (scholarship guaranteed for domestic students). DM me if you know of anyone interested, including you
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Joanna W Jachowicz
Joanna W Jachowicz@jwjach·
interested in 3D genome organization during early development? want to understand how it is shaped by RNA? you like data analysis and developing new computational tools? 🧬💻🧐 With @golobor we are recruiting a PhD student/intern to work with us at @IMBA_Vienna
Anton Goloborodko @[email protected]@golobor

My lab is looking for PhD students with a background in physics and/or biochemistry/quantitative biology. If interested, please apply to the VBC graduate school. Deadline: Oct 15th.

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Christopher Douse
Christopher Douse@ch_douse·
Delighted that this is finally out! Thanks to @Faulkner_Lab @todd_macfarlan and the other reviewer for good and constructive comments that arrived in my inbox the day after my second child was born... paper here nature.com/articles/s4146…. Short reflection on new stuff...
Christopher Douse@ch_douse

Happy and proud to share my lab’s study on how DNA methylation and the HUSH-MORC2 corepressor work together, out last week on biorxiv: biorxiv.org/content/10.110… A fantastic collaboration with our colleagues at @JakobssonLab @Lund_Stem...1/7

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Max Planck Society
Max Planck Society@maxplanckpress·
Calling all emerging scientists - it’s time to send us an application! 😉😎 Lead your own #MaxPlanck Research Group w/ €2.7M in funding over 6 yrs, full independence & resources to hire staff. State-of-the-art infrastructure awaits you!🌟 Apply today➡️mpg.de/career/max-pla…
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Heng Li
Heng Li@lh3lh3·
Preprint on "BWT construction and search at the terabase scale". We can compress 100 human genomes to 11GB in 21 hours, find SMEMs with it, do affine-gap alignment and retrieve similar local haplotypes. 7.3Tb commonly sequenced bacterial genomes ⇒ 30GB arxiv.org/abs/2409.00613
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Khám phá

@TrinaKarabi @SDStatePharmacy @marcotrizzino @ControllingLMNT @BrugmannLab @JakobssonLab @Dev_Cell @PRAndersen