Hiller Lab

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Hiller Lab

Hiller Lab

@HillerLab

Group of Prof Sebastian Hiller. Structural Biology Research Group @biozentrum @Unibasel. Unravelling Biomolecular Mechanisms. (run by students)

Basel, Switzerland Tham gia Mart 2019
373 Đang theo dõi1K Người theo dõi
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Basile Wicky
Basile Wicky@BasileWicky·
New lab preprint! We used design to sample protein space, and developed a HT NMR pipeline to analyze 384 designs; a first glance into seq-struct-dynamics at scale! An exciting collaboration with @HillerLab, and @DlanAbr's first paper! biorxiv.org/content/10.648…
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Hiller Lab
Hiller Lab@HillerLab·
These condensates could revolutionize our understanding of protein folding and inspire new therapies for misfolding diseases like diabetes and cancer. A new era for targeting ER function! #Biomedicine #Therapeutics
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Hiller Lab
Hiller Lab@HillerLab·
Last day for our summer student @Shreyan11_11, who has done great work during his one and a half months in our lab working on the Hsp70 functional cycle! If you are looking for a PhD student in the next few months, @Shreyan11_11 will be a great fit for any lab!
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Hiller Lab
Hiller Lab@HillerLab·
Congratulations to PhD student Marta and NMR Facility Manager Thomas for the publication of their great work on Photo-CIDNP in JACS ! pubs.acs.org/doi/full/10.10…
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Biozentrum, University of Basel
Biozentrum, University of Basel@biozentrum·
A Day Dedicated to Science: On June 12, the @biozentrum community gathered for its traditional symposium. Bringing together around 300 Biozentrics, the event showcased a broad spectrum of cutting-edge research while fostering interdisciplinary dialogue and collaboration.
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Hiller Lab
Hiller Lab@HillerLab·
Our data reveal that calcium doesn’t affect the cycle, but combined with ADP accumulation it creates off-pathway states that prolong the nucleotide-bound lifetimes. This changes Hsp70’s function extending client protein interaction times — a new layer of cellular regulation!
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Hiller Lab
Hiller Lab@HillerLab·
This versatile in-cyclo NMR platform is adaptable to study diverse ATP-driven molecular machines beyond Hsp70 — enabling precise dissection of functional cycles, allosteric regulation, and the effect of cofactors or co-chaperones at unprecedented resolution. #MolecularMachines
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Hiller Lab
Hiller Lab@HillerLab·
Tired of costly cloning software? Try IVA Prime: a free, game-changing tool for automated primer design in IVA cloning! Simplify complex cloning with one click, reduce errors, and save time. Visit ivaprime.com. doi.org/10.1093/nar/gk… collaboration with @JGarciaNafria
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Hiller Lab
Hiller Lab@HillerLab·
Big week ahead for our lab! @annaleder_ presents at the 1.2 GHz inauguration in Zurich, and @GuillaumeMas2 speaks at @ENC_Conf (5:05pm PT) in Asilomar #ENCISMAR2025. Expect groundbreaking ideas on enzymology, molecular chaperones, LLPS, & ER biology. Don’t miss it!
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Hiller Lab
Hiller Lab@HillerLab·
Happy to announce the release of our collaboration with the @JenalLab! @GuillaumeMas2 led the NMR analysis, identifying the toxin’s product and unravelling the enzymatic properties of the toxin-antitoxin system.
Biozentrum, University of Basel@biozentrum

Researchers @JenalLab and @HillerLab have discovered how a dangerous human pathogen causing pneumonia uses a kind of molecular "sleeping pill" to enter a dormant state to persist antibiotic treatment. @UniBasel_en @NCCR_AntiResist @snsf_ch @EMBOPress ow.ly/8Ro550TQrnl

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Khám phá

@DlanAbr @BasileWicky @Spang_Lab @MaierLab @Biozentrum @UniBasel @annaleder_ @guillaumemas2