How to determine the proteome of cellular compartments?
We established a method to do just that, published in @elife: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLife.…
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The Spang Lab
247 posts
The Spang Lab
@Spang_Lab
We are scientists interested in understanding the basics of how a cell, the building block of our body, works. @biozentrum @UniBasel_en #cellbio #Biozentrum
Basel, Switzerland Katılım Eylül 2018
83 Takip Edilen933 Takipçiler
Arf1 regulates TORC1 through two different ways! Great work by @EnklerLudovic and great collaboration with @MZavolan lab! #cell #biology #signaling
TORC1 spatial segregation and hysteresis are regulated by the small GTPase Arf1 biorxiv.org/content/10.648…
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The Spang Lab retweetledi
Switch on for the newest in Small GTPases at #SmallGTPSRC this June! Join @SpangAnne of @Spang_Lab alongside organizers Daniel Abankwa from @uni_lu, @ChristinBurd, @jcfromme, and Sabine Hilfiker from @Rutgers_NJMS. Register and submit your abstract by April 27: bit.ly/4cilsf0
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What if you could cut out sub cellular structures and measure their proteome?
SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection biorxiv.org/content/10.648…
awesome work by @CurdinF, @Alexia__F ,@Biehli & Alexander Schmidt
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Check out our new paper on mRNA levels + P-body condensate properties. Congrats to Debdatto Mookherjee and @MadeleineRommel, super collaboration with @MariaHondele @FerdinandWeidn1 @MatejSiketanc
Non-translated mRNA levels determine P-body properties biorxiv.org/content/10.648…
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Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104 ! @biozentrum @UniBasel_en #cellbio
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites biorxiv.org/content/10.648…
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Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites biorxiv.org/content/10.648…
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Check out our newest finding on Arf1, the Jack of all trades: ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs biorxiv.org/content/10.648…
#endosome #recycling #cellbio
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A little stress is good for you in #health #ageing ! #Diet is important! Take a look at our article with Emmanouil Kyriakakis as 1st author! @UniBasel_en @NatureComms @snsf_ch #Longevity #healthspan
nature.com/articles/s4146…
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wonderful collaboration with the @HillerLab . check it out!
Biozentrum, University of Basel@biozentrum
Proteins must be folded into their correct shapes to function properly. @HillerLab discovered tiny “folding factories” in cells that enable efficient and accurate protein folding. @UniBasel_en @snsf_ch @NatureCellBio ow.ly/4IjZ50WCF4p
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The Spang Lab retweetledi
I'm thankful to all our collaborators @Spang_Lab @samit2104, Anne Grahl, @LabStahlberg, Meltem Tatli and Dongchun Ni and my mentor, Stephan Grzesiek, who helped us bring this story to life.
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Check out our latest paper! Congrats to Daniel Ott @Samit2104 and Jachen Solinger! well done! Coordination between ESCRT function and Rab conversion during endosome maturation | The EMBO Journal embopress.org/doi/full/10.10…
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The Spang Lab retweetledi
Congratulations to Anne Spang @Spang_Lab for receiving the renowned Lelio Orci Award. The award honors her pioneering work in intracellular organization and her research achievements in Cell Biology. @LS2Switzerland @UniBasel_en
biozentrum.unibas.ch/news/detail/an…
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@AdrianoAguzzi Once you’re back on your bike and also work your other muscles again, your weight gain will be muscle mass ! Happy New Year!
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Wonderful meeting! Thank you for organizing and having me!
Johannes Herrmann@Herrmann_lab
The newly founded study group on Cellular Organelles of the German Society for Biochemistry and Molecular Biology @GBM_eV had its first symposium in Kaiserslautern. Exciting meeting with excellent talks and posters! So much fun! Next year, we organelle lovers meet in Düsseldorf!
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The Spang Lab retweetledi
From @Spang_Lab & @DrBakhtiar_S lab: LRBA gene mutations linked to severe childhood immune disorders involve Arf1-dependent pathways. These insights into endosomal traffic regulation may open doors to innovative treatments for LRBA deficiency hubs.la/Q02Rdsbx0
#lysosome
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The result of the wonderful collaboration with @DrBakhtiar_S lab is out! Great job @ViktriaSzentgy1 and Leon Lueck!
Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis rupress.org/jcb/article/22…
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Awesome meeting bridging cell polarity, membrane and RNA trafficking with cell fate determination. Very interactive and collaborative community pushing boundaries meeting in a very beautiful place.
Francesca Bottanelli@Fran_Bottanelli
Save the date for the EMBO workshop on Cell polarity and membrane dynamics organized by Ed Munro and myself! 18-23 May 2025 in the beautiful San Feliu! Signup here to get more info as soon as the website is up! please RT coming-soon.embo.org/w25-32
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