Basile Wicky

Excited to share that I'll be starting a group @ETH_BSSE researching at the intersection of protein design, biology and AI. Come join us! x.com/ETH_en/status/…

#JobAlert 🚀 Exciting opportunity for young scientists - please share: tinyurl.com/2rajyepc @ETH_en #BIIE @BaselStadt

We're hiring! If you're interested in applying protein design to improving AAV we'd love to hear from you! Fully-funded 2 year collab postdoc between my group at ETH D-BSSE (in Basel) and Denis Phichith at Roche. Job description and application portal: lnkd.in/e3P7HXt4

New lab preprint! We used design to sample protein space, and developed a HT NMR pipeline to analyze 384 designs; a first glance into seq-struct-dynamics at scale! An exciting collaboration with @HillerLab, and @DlanAbr's first paper! biorxiv.org/content/10.648…

Super excited to share our paper “Design of amyloidogenic peptide traps” is out now! 🧠 nature.com/articles/s4158… Special thanks to @eaandrzejewska , Danny Sahtoe and David Baker

Short summary thread of our recent review on de novo protein design: (Poster-sized figure (36 x 48 inches) for printing: drive.google.com/file/d/1sG3OlE…)

@karina_pombo That's amazing!! Congrats!!

I'm thrilled to announce the opening of my laboratory today at the Rosalind Franklin Institute in Oxford & visiting at Oxford University. Very excited to start my independent path as group leader in such a vibrant place! #newPI

I keep on preaching to my lab about the usefulness @ChatGPTapp for coding, but real-life demos might be more effective. A thread on a neural network we quickly developed to classify antibiotics sensitivity 🧵 (1/10)

The commentary I wrote is now live at Nature Biotech: nature.com/articles/s4158… (free version rdcu.be/dwSSy).

Continuous directed evolution is so cool 🥹

LigandMPNN preprint: biorxiv.org/content/10.110… LigandMPNN inference code + model weights (including ProteinMPNN, SolubleMPNN etc): github.com/dauparas/Ligan…

Beautiful work by the talented @KieraSumida and Reyes! Their findings on the quantitative tradeoff between seq conservation, designability and function (fig. 3f/g) is particularly insightful, and will be useful for many future protein engineering efforts!

#openposition Exciting opportunity for a #postdoc: be part of the partnership @ETH_en and @Roche and become a Next-Gen Bioengineer > u.ethz.ch/m4Lwj Thanks for sharing!

Expanding protein pore palette beyond biology. Computational design of protein pores with various shapes and sizes. (Potential applications: Nanopore sensing, DNA/Protein sequencing, Custom pores for selective membranes and ligand-gated channels for cellular delivery.....)

We are hiring! Come join us for a PhD in Computational Language Evolution @ETH in Basel @ETH_BSSE and the National Research Program on Evolving Language @NCCR_Language. We are looking forward to receiving your application jobs.ethz.ch/job/view/JOPG_…

We're looking for a PhD student interesting in protein design and tech development. Exciting project interfacing protein @structbiolbxl and solid-state nanopores @imec_int. Computational design of hybrid nanopore sensors. Apply by December 15th! imec-int.com/en/work-at-ime…

Dorado v0.5 NCM release 🎉 - new simplex models - faster - higher accuracy - easier to use (auto model selection) - hemi-methylation (duplex mods) - primer & adapter trimming - custom barcodes #nanoporeconf github.com/nanoporetech/d…

Is binarization of scATAC-seq data really necessary? The conclusion from our analysis is that a quantitative treatment is in fact beneficial. Now out in Nature Methods! @gagneurlab @fabian_theis nature.com/articles/s4159… Many additions since the preprint 👇(1/n)

For anyone interested in generating publication-quality secondary structure diagrams from PDB files, SSDraw is available and now published by @ProteinSociety onlinelibrary.wiley.com/doi/full/10.10…