Shabaz Lab

I am pleased to announce the final program for the EUPA Brixen Proteomics Summer School 2026 now also a @FEBSJournal Advanced Lecture Course Thank you @thermofisher @EvosepBio Ionopticks @ReSyn_Bio @SIGNATOPE_GmbH Momentum Biotechnologies @bsi_peaks @biognosys for support!

Turns out you can do cysteine profiling without lysing the cells first. nature.com/articles/s4155…

The Brixen Proteomics Summer School is back! Speaker list is already looking strong!

We asked the question do solid particles have a role to play in the separation space within modern proteomics? Would these very small particles in short columns for fast gradients be a good idea for modern fast and sensitive MS? The answer was not no! pubs.acs.org/doi/10.1021/ac…

Proud to announce my first publication is out in @PLOSPathogens ! Huge thanks to my co-first author Wael, @brennanlab, and @castello_lab. The paper explores how tick RNA-binding proteins respond to UUKV infection, you can find the paper here dx.plos.org/10.1371/journa…

🚨 New paper in @PLOSPathogens! 🚨 Together with @brennanlab, we mapped – for the first time – how tick RNA-binding proteins rewire during virus infection. 283 proteins changed activity, revealing key players in viral fitness. Read here: doi.org/10.1371/journa…

We were just using NHS chemistry for some protein conjugation when we noticed some odd prominent side products. It turns out thio-nhs reagents (a major class of reagents) has some notable side reactions that happen all the time. nature.com/articles/s4146…

So Nikita really wanted to present his poster (ThP648) on the omnitrap at #ASMS2025. Well with the power of the internet he can! Visa be damned. Also he is fresh and not destroyed by all the vendor hospitality...

@biorxiv_sysbio @nesvilab The combination of all of the above allowed us to perform perform DIA with UVPD and ECD and EID approaches on samples originating from human, plant and bacteria – everyone (6/n) - happy #ASMS2025 everyone

@biorxiv_sysbio We then implemented the model in the MSBooster module of the popular Fragpipe software package, allowing significantly improved results and broad application. – @nesvilab and Kevin L. Yang (5/n)

Integrating Alternative Fragmentation Techniques into Standard LC-MS Workflows Using a Single Deep Learning Model Enhances Proteome ... biorxiv.org/content/10.110… #biorxiv_sysbio

Here's an LC story from our lab. Unlike a lot of stories with questions as titles this one is a maybe yes! Interesting for those high throughput proteomics people! biorxiv.org/content/10.110…

Deadline is fast approaching!

🚨🚨News: Interested in the proteome configuration that makes a cell permissive or hostile to virus infection? Why mRNA levels do not fully reflect the proteome status after interferon treatment? See the new paper from @castello_lab and Mohammed lab mcponline.org/article/S1535-…

We are excited to share our new Nature Methods paper describing the Chip-Tip workflow for single-cell proteomics identifying >5,000 proteins in single cells, enabling PTM analysis without enrichment and throughput of up to 120 single cell samples per day: rdcu.be/d6qJe

A Basic solution to a very common problem mcponline.org/article/S1535-…

The Brixen summer school speaker list has been finalised. It's going to be another fantastic edition!