David Gate

Big day today!

Genetically altered astrocytes that express chimeric antigen receptors offer a promising immunotherapy system capable of clearing accumulations of amyloid-β in the brains of mice—a hallmark pathological feature of #AlzheimersDisease, according to a new study in Science. 📄: scim.ag/3NjPIfP #SciencePerspective: scim.ag/4rgI1oL

Congrats @DGateLab on having one of the Top 3 Episodes of Breakthroughs Podcast in 2025! If you haven't listened you can do so and learn more here; news.feinberg.northwestern.edu/2025/12/12/top…

Key to research success: ambition in vision, but pragmatism in execution. You must be guided by a long-term, ambitious goal that addresses a fundamental problem, rather than chasing incremental gains on established benchmarks. Yet, your progress should be grounded by tractable short-term metrics/tasks that force you to constantly make contact with reality.

We are proud to announce a collaboration with @ARC_Neuro at Northwestern University Feinberg School of Medicine to harness AI for rapid discovery and innovation in Alzheimer’s disease research. Using Lens, the Center and Tempus teams will work together to uncover genomic patterns that have the potential to advance the understanding of Alzheimer’s disease, investigate the gene and cell types affected, enable the development of new therapeutics, and accelerate the creation of novel clinical applications. Learn more: tempus.co/43EIlVJ

I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12 Full study 🔗: nature.com/articles/s4159…

The Gate lab is fortunate to have such a talented scientist like @TerryRSuk joining us soon. Check out his impressive work!

In brains of people immunized against Aβ, postmortem omics reveal microglial plaque clearing pathways. @NorthwesternU ow.ly/3cOl50VitbY

It’s quite an experience to have some of your favorite labs like ⁦@TheColonnaLab⁩ and ⁦@Haass_Lab⁩ comment on your lab’s research. Great reporting by Alzforum! alzforum.org/news/research-…

This Northwestern Breakthroughs podcast nicely encapsulates our study. The host does a great job leading the discussion for the lay audience to digest our work. I hope this allows people to better understand the results and impact of this study. youtu.be/bZrdwGQ_Ok0

@JustinPerryPhD @jonykipnis @ARC_Neuro You both make good points! I really appreciate the input.

@jonykipnis @DGateLab @ARC_Neuro I think the point I'm trying to make is to not over-interpret transcription data, especially given how poorly it correlates with protein (let alone the actual behavior of a cell) 🤷‍♂️.

Amazing study from @DGateLab and his awesome new center @ARC_Neuro. This manuscript defines the microglial response to amyloid-beta immunization. Very important findings for the field with broad implications for Alzheimer’s treatment. Wow! Bravo 👏

@jonykipnis @WashU @washumedicine Congrats! What a team!

Extremely thankful to Carol and Gene Ludwig Family Foundation for their support and trust in us and our science! We hope to do great things with this award and to further grow exceptional neuroimmunology research @WashU @washumedicine medicine.washu.edu/news/4-5-milli…

@TheIbrahimLab @ARC_Neuro @LynnOlst Thank you, my friend!

@DGateLab @ARC_Neuro @LynnOlst Wow, an inspiring tour de force, David! Congratulations to you and your excellent team!

This video describes the findings from our recent study conducted at ⁦@ARC_Neuro⁩. In the video, lead author ⁦@LynnOlst⁩ and I discuss the findings and their implications for Alzheimer’s disease. youtu.be/pnRzktJRWAo

アルツハイマー病の治療は脳自身のクリーンアップクルーにあるかもしれません nipponese.news/%e3%82%a2%e3%8…

Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)

Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passive and actively immunized #Alzheimer’s disease patients @NUFeinbergMed nature.com/articles/s4159…

More excellent work from the brilliant @LynnOlst. I’m a very proud PI today. More to come from @ARC_Neuro!

Excited to announce that we are recruiting at our new Neurogenomics Center at Northwestern! We are looking for passionate postdoc candidates to join our team. nature.com/naturecareers/…