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Prof Linda Gay Griffith@LindaGGriffith1·1d

@JustinPerryPhD I have never worked harder for an NIH grant than I did for this one - it is built on 15 years of backbreaking labor in the gynecology trenches, scrambling for $$ as gynecology has never been well-funded. The NOFO was issued in 2024. The team has investigators in the midwest. It required having other funding to leverage the work in the Center. I raised $$ from philanthropy and industry partners. Don't despair, I am not being a pig sucking up $$ to just piddle around. Either we help drugs get in the clinic or our funding gets cut - it is a U mechanisms with milestones. I am hell bent on getting drugs with new MOA into the clinic and I will wring the most out of every $$ I get from NIH to do that.

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Prof Linda Gay Griffith@LindaGGriffith1·1d

Very grateful to the American Taxpayers, and to NIH, for giving us a chance to improve how therapies are developed, with the aim of getting safer and more effective therapies to patients on a faster timescale than you would ever have with animals as your only model system. Also, huge thanks to all the patients who consented to our studies and contributed to our biobank. As a patient myself, I know how much it means to contribute tissues that might help someone else avoid suffering in the future.

🚨 Today, @NIH announced a major funding push for non-animal research. As part of its Complement-ARIE program, the agency is devoting $150 million to "develop and scale research methods that better simulate human biology and reduce reliance on animal models." This funding will establish technology development centers to boost non-animal methods for research on gynecological conditions, cardiac disease, neurological disorders, and rare diseases, all areas that SAO has pushed NIH to modernize. In addition, a NAMs Data Hub and Coordinating Center and a Validation and Qualification Network will ensure that these technologies are standardized, accessible, and marketable. Some awards have already been issued to @LindaGGriffith1 of @MIT, Ivan Rusyn of @tamuvetmed, @JimWellsLab of @CincyChildrens, and @FNIH_Org. Learn more: nih.gov/news-events/ne…

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Justin Perry - Perry Lab@JustinPerryPhD·1d

@LindaGGriffith1 Hi Linda. I don't doubt your dedication or efforts. But almost every scientist has a story of trials & tribulations. I've been consistent on my criticism of U/P & consortium mechanisms for years, so the fact I value your work doesn't negate that criticism.

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Justin Perry - Perry Lab@JustinPerryPhD·1d

One would think that the elimination of NOFOs would get rid of the legacy and siloed funding that has enriched only a few well-connected labs over the last two decades. It turns out it's just being shifted from some well-connected groups to other well-connected groups.

🚨 Today, @NIH announced a major funding push for non-animal research. As part of its Complement-ARIE program, the agency is devoting $150 million to "develop and scale research methods that better simulate human biology and reduce reliance on animal models." This funding will establish technology development centers to boost non-animal methods for research on gynecological conditions, cardiac disease, neurological disorders, and rare diseases, all areas that SAO has pushed NIH to modernize. In addition, a NAMs Data Hub and Coordinating Center and a Validation and Qualification Network will ensure that these technologies are standardized, accessible, and marketable. Some awards have already been issued to @LindaGGriffith1 of @MIT, Ivan Rusyn of @tamuvetmed, @JimWellsLab of @CincyChildrens, and @FNIH_Org. Learn more: nih.gov/news-events/ne…

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Justin Perry - Perry Lab@JustinPerryPhD·6d

You need to register for a free account which is sort of annoying. But this is a little interview on our recent microplastics paper in Live Science. livescience.com/health/micropl…

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Justin Perry - Perry Lab@JustinPerryPhD·7 Mar

@rosslevinemd @MSKCancerCenter @Cycle4Survival Deal! I can make us some fresh chicken and duck eggs for protein after.

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Justin Perry - Perry Lab@JustinPerryPhD·7 Mar

@rosslevinemd @MSKCancerCenter @Cycle4Survival Awesome! I always see our colleagues doing this but I have no idea how to participate! I have a road bike and used to cycle a bit. Would love to next year.

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Justin Perry - Perry Lab@JustinPerryPhD·7 Mar

interview: during my visit to CNIC, we discussed some of the lab's work and why it matters, as well as some broader points, like why I find it exciting that we are wrong all of the time. read more here -> cnic.es/en/noticias/ju…

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Elizabeth McKenna@ElizSMcKenna

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Justin Perry - Perry Lab@JustinPerryPhD·4 Mar

I'm not sure microplastics present in cancer matter at all. We will certainly start testing hypotheses around the topic. But it does seem like that could easily be a @CancerGrand Challenges topic. Email me (perryj at mskcc.org) if interested in a collab.

The new @CancerGrand Challenges teams have just been announced! Read about the teams tackling cancer avoidance, mechanisms driving mutational signatures, the dark proteome, cancer neuroscience, and rewiring cancer cells now in @CD_AACR: aacrjournals.org/cancerdiscover…

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Justin Perry - Perry Lab@JustinPerryPhD·3 Mar

@bimald @razibkhan His cmment also glosses over the tradition of solid experimental psychology beginning with Harry Harlow.

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Justin Perry - Perry Lab@JustinPerryPhD·2 Mar

@LindaGGriffith1 @TheGregYang (I'm an ulcerative colitis patient who gets crushed by travel of any form)

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Prof Linda Gay Griffith@LindaGGriffith1·2 Mar

@JustinPerryPhD @TheGregYang Justin. How does fermentable fiber help or not, if you have the right butyrate producers like f prausnitzii

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Greg Yang@TheGregYang·1 Mar

my energy in the past month: slow, fluctuating progress! observations: - past week I had 2-3 consecutive days of good energy! then crashed a bit :( - I'm "crashing" like every 3-4 days on average, but that's lengthening - the stack of butyrate + omega-3 plasmalogen + phosphatidylcholine can reliably pull me out of a 5 into 5.5-6 range what the numbers mean: - 5 is like tired and I'd rather stay in bed but can force myself to do things if I have to - 6 is like I can do things I need to but my brain is kinda empty and slow - 7 is like I don't feel any resistance to do the things I need to do - 8 is like that but my brain is running noticeably faster than 7

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Justin Perry - Perry Lab@JustinPerryPhD·2 Mar

@LindaGGriffith1 @TheGregYang A lot, but the key is what you say. It seems you need the right commensal repopulation coupled with increased fiber availability, to both avoid pathobiont takeover & promote activity of butyrate producers. This, plus taurine (story coming out on that) is my post-travel regimen.

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Justin Perry - Perry Lab@JustinPerryPhD·2 Mar

@TheGregYang Here's paper link. pmc.ncbi.nlm.nih.gov/articles/PMC76…

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Justin Perry - Perry Lab@JustinPerryPhD·2 Mar

@TheGregYang Interesting re butyrate. We found that butyrate enhances efferocytosis (clearance of dead cells & debris, essential for all tissue function, normal turnover, & homeostasis). We also show how antibiotics disrupt this. Sadly, no $ for Lyme hypothesis we have tinyurl.com/mrytfeya

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Justin Perry - Perry Lab@JustinPerryPhD·2 Mar

Unfortunately, so long as a tissue culture method requires Matrigel or related substances, they are a poor approximation of a tissue, especially as a tissue requires integration of tissue-resident macrophages (essential for tissue development & maintenance). TRMs love Matrigel.

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Justin Perry - Perry Lab@JustinPerryPhD·1 Mar

@DavidAFrench Sure, Trump should have. But Congress has known for quite some time this was potentially imminent and they never saw fit to vote on it during the interim. If we really want Congress to take back its power, then it needs to be called out when it fails to assert said power.

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David French@DavidAFrench·1 Mar

Abraham Lincoln, reflecting on the power to declare war: "Kings had always been involving and impoverishing their people in wars, pretending generally, if not always, that the good of the people was the object. This, our convention understood to be the most oppressive of all kingly oppressions and they resolved to so frame the Constitution that no one man should hold the power of bringing this oppression upon us." Trump should have gone to Congress, or he should not have attacked at all: nytimes.com/2026/03/01/opi…

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Justin Perry - Perry Lab@JustinPerryPhD·1 Mar

@EricTopol @Cancer_Cell Sort of overlooked (including in a recent @CellPressNews paper), but the @KeshariLab showed beautifully that CAR T Cells can be metabolically engineered to use an abundant endogenous metabolite. In that paper, we showed you can do the same w/ macrophages. cell.com/cancer-cell/ab…

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Eric Topol@EricTopol·28 Şub

Some very good news about engineering our cells vs cancer (accelerating the CAR). A short thread 1. For background, a new 5★ review on cancer immunotherapy @Cancer_Cell sciencedirect.com/science/articl…

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Justin Perry - Perry Lab retweetledi

Justin Perry - Perry Lab@JustinPerryPhD·25 Şub

Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from @ThePerryLab @MSKCancerCenter in @ImmunityCP @CellPressNews, which is the exception. /1

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Justin Perry - Perry Lab@JustinPerryPhD·28 Şub

@bimald @rekesk @jonykipnis In particular because it isn't really clear how radical change, including throwing the baby out with the bathwater, will lead to something better. Perhaps it's the conservative in me, but revolutionary change (instead of modest reforms over time) never works.

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Jonathan Kipnis 🟦@jonykipnis·27 Şub

They are destroying science in our country 🤦‍♂️How long will it take us to recover?

Denis Wirtz@deniswirtz

NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true. Here is a graph showing how many fewer new funding opportunities that NIH has posted over time. -91%, a trend that started on Jan 2025.

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Justin Perry - Perry Lab@JustinPerryPhD·27 Şub

@pedrosvdr @jonykipnis Yeah I hadn't seen it and then just now it popped up on my feed (of course). The RFAs are independent of OMB, which is why I didn't understand why the graph Jony showed indicated what he said.

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Pedro Saavedra@pedrosvdr·27 Şub

@JustinPerryPhD @jonykipnis OMB is delaying release of funds. See here: nature.com/articles/d4158…

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