Paul Miller

29 posts

Paul Miller

Paul Miller

@PMillerLab

science

Cambridge 加入时间 Mayıs 2021
59 关注84 粉丝
Taufiq Rahman
Taufiq Rahman@RahmanLab·
a reader at Emmanuel street bus stop, Cambridge
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Saad Hannan
Saad Hannan@saad_hannan·
This team effort enabled us to discover that neural cell surface expression is key for GABA-B neurodevelopmental diseases. We also provide pointers for much needed therapy. Incredibly proud of our talented students and colleagues from @uclbiosciences Smart Lab and @blizard_inst
Brain@Brain1878

Minere et al. provide new insights into the mechanisms by which GABA-B receptor variants give rise to neurodevelopmental disease, and show that positive allosteric modulators have therapeutic potential. tinyurl.com/4saxubr2

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Paul Miller
Paul Miller@PMillerLab·
Congrats to @PMillerLab and @UnivCamPharm protégé, Mr (now Dr!) Ollie King on successful defence of his PhD thesis! Huge thanks to Dr Janet Kumita @jrkumita and Dr Greta Hultqvist for putting Ollie through his paces!
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Yin Yao Dong lab
Yin Yao Dong lab@CMS_CDG_Oxford·
Congratulations to @Anna_Liiiiiiii for passing her DPhil viva!!! 👏 ❤️ 🥳🍾 Thank you very much @inwardopen and @PMillerLab for being her examiners! It was great to chat to you and get your expert adverse on Anna's work.
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Paul Miller
Paul Miller@PMillerLab·
@RyanHibbs10 Congratulations, Ryan. Fantastic achievement by all involved! I look forward to reading it!
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GPCR_Ladds
GPCR_Ladds@GpcrL·
Delighted to have this manuscript published with my great collaborator in Biochem, the X'less Daniel Nietlishpach. The first of many to come we hope. nature.com/articles/s4146…
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Paul Miller
Paul Miller@PMillerLab·
For the isoxazoles we observed interesting pocket displacements between negative vs positive modulators, the first such structure-activity relationship observed for a GABA-A receptor, and hope this study can empower future drug-design efforts against this valuable target.
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Paul Miller
Paul Miller@PMillerLab·
We used radioligand binding, ePhys and cryo-EM studies to give detailed insight into b-carboline, benzo, and isoxazole selectivity. Special thanks to Maria-Clemencia Hernandez & Giuseppe Cecere at Roche for support and some wonderful compounds to study!
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Taufiq Rahman
Taufiq Rahman@RahmanLab·
Had my first lecture to medics and vets today...really thankful to them for turning up in good number despite the horrible weather....hope they won't regret much...
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Ewan St. John Smith
Ewan St. John Smith@psalmotoxin·
Research requires endless form filling…
GIF
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