Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use?  Our new study found that carnitine biosynthesis is crucial for fuel switching science.org/doi/10.1126/sc…

To our surprise, the carnitine biosynthesis pathway influences the optimal efficacy of GLP1-based anti-obesity therapies! You can see the full MS here until it lasts: science.org/eprint/ARC749J….

@KajimuraLab Impressive work!

@KajimuraLab You note the role of Thyroid hormone. Carnitine supplementation has been shown to help with fatigue among some people (with sufficient T3) with continuing symptoms despite treated hypothyroidism. pubmed.ncbi.nlm.nih.gov/27432821/ Are there implications for this population?

@KajimuraLab Can we get a public paper on this, without a paywall please?

@KajimuraLab Didn't Bruce Ames demonstrate this like 25 years ago or more?

Nice work on cellular fuel preference! Carnitine's role in fuel switching is critical, as it transports fatty acids into mitochondria for oxidation. What implications does this have for metabolic disorders? Do you see any therapeutic potential in modulating carnitine biosynthesis? For an in-depth review, check out sciqst.com, where you can generate comprehensive biomedical insights. #CellBiology #Metabolism

@KajimuraLab @LodhiLab Congrats Shingo! Beautiful work!

@KajimuraLab Congrats! Fascinating story!

@KajimuraLab Beatiful work, congratulations!

@KajimuraLab Congratulations