Halfmann Lab

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Halfmann Lab

Halfmann Lab

@HalfmannLab

The Halfmann Lab explores the cellular and evolutionary implications of protein self-assembly.

Kansas City, MO انضم Eylül 2015
96 يتبع593 المتابعون
Halfmann Lab
Halfmann Lab@HalfmannLab·
Also, check us out on NPR.org front page! Congrats again @arg_arginine. Thanks to pioneering structural biology of death domains (DFDs) from @WuLabHarvard and previous collab with Zhijian 'James' Chen @UTSWMedCenter that led us to the protein batteries concept.
Stowers Institute@ScienceStowers

Why would a healthy cell decide to die? Investigator @HalfmannLab joined @NPR's @npratc with @NPRjonhamilton to discuss his #research on how and why cells decide to self-destruct—a process known as programmed cell death. 🎧 Listen here: n.pr/3L4i1gF

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Halfmann Lab
Halfmann Lab@HalfmannLab·
@arg_arginine @ScienceStowers YOUR work, Alex! After years of effort and teasing apart what we've actually uncovered here, I'm so glad we can finally plant our flag on this discovery. Excited to see if other proteins function like batteries.
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Halfmann Lab
Halfmann Lab@HalfmannLab·
MD simulations let you watch a microsecond or so of one protein's life in a box. But in the cell thousands of proteins work together, over much longer timescales. With @IlyaVakser's group and their new simulation method, GCell, we're now beginning to see this emergent behavior!
Amar Singh@DrSinghAmar

Delighted to share #MyACSCover and our recent study, "Highly Optimized Simulation of Atomic Resolution Cell-Like Protein Environment", published by @ACSPublications in J of Phys Chem B. Congratulations to Prof. @IlyaVakser , @HalfmannLab , and the team! doi.org/10.1021/acs.jp…

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Halfmann Lab أُعيد تغريده
Roy Kishony
Roy Kishony@RoyKishony·
1/n Can LLMs perform scientific research? And, can they do so while enhancing key scientific values including transparency, traceability & verifiability? Check out our preprint on the "data-to-paper" platform. w the amazing @TalIfargan @LostInTranscrip arxiv.org/abs/2404.17605
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Halfmann Lab أُعيد تغريده
Stowers Grad School
Stowers Grad School@StowersGrad·
Meet a #StowersGrad faculty member! Randal Halfmann (@HalfmannLab) seeks to understand #aging, the inexorable decline in cellular and bodily function that results from the unidirectional nature of self-assembly by supersaturated proteins. #PhD Learn more: bit.ly/43TtyVw
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Halfmann Lab
Halfmann Lab@HalfmannLab·
Kudos also to a responsive editorial staff, who offered to provide Senior Editorial oversight in the second round of review. I feel empowered to refocus on science rather than academic politics – this feels like the future of science publishing. @ASAPbio_
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Halfmann Lab
Halfmann Lab@HalfmannLab·
Thank you, @eLife, for transparent review! Exercising the power to publicly address a reviewer’s untenable position changed the outcome for our latest paper, the findings of which are recognized as “fundamental” by eLife’s updated assessment. elifesciences.org/reviewed-prepr…
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Halfmann Lab
Halfmann Lab@HalfmannLab·
Great job Justin! Now we just need the yeast to write their own paper. #CRC23
Halfmann Lab tweet media
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Halfmann Lab
Halfmann Lab@HalfmannLab·
@SaelicesL @Hlashuel Echoing Lorena- Hilal, your keynote on night 1 beautifully set the scene for the rest of the conference. Thank you so much! Looking forward to 2025.
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Lorena Saelices Gomez - she/her/hers/ella
Lorena Saelices Gomez - she/her/hers/ella@SaelicesL·
@Hlashuel @HalfmannLab Thank you so much Hilal! Let me say that your contribution was invaluable: delivering a groundbreaking keynote lecture, promoting discussion through thoughtful questions to speakers, & sharing your views on diversity & inclusion as a member of our DEI panel. A delight THANK YOU.
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Halfmann Lab
Halfmann Lab@HalfmannLab·
Still unpacking my supersaturated brain after a fantastic #PACSRC FASEB protein aggregation conference. Thanks to all the speakers and attendees for making this so worth while! And BIG thanks again to our sponsors! #amyloid
Halfmann Lab tweet mediaHalfmann Lab tweet mediaHalfmann Lab tweet media
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Halfmann Lab
Halfmann Lab@HalfmannLab·
Ron is a pioneer on the mechanism of polyQ aggregation, and an inspiration to me. It was a nice surprise that our new in-cell method validated his twenty year-old model derived from rigorous test tube experiments. Good science stands the test of time!
Stowers Institute@ScienceStowers

#ICYMI: New #research from the @HalfmannLab revealing the start of #Huntingtons disease published in @eLife. Here is what Ron Wetzel, PhD, @PittTweet @UPMC, had to say about the findings. Read more: bit.ly/43XnOsB #ScienceTwitter #Discovery

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Halfmann Lab
Halfmann Lab@HalfmannLab·
Link to the primary paper: #tab-content" target="_blank" rel="nofollow noopener">elifesciences.org/reviewed-prepr…
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Halfmann Lab
Halfmann Lab@HalfmannLab·
Now out in eLife – our epic journey into the heart of polyQ to deduce the structure of an amyloid nucleus. Spoiler: it’s not #LLPS. Even more surprising, oligomerization blocks nucleation!
Stowers Institute@ScienceStowers

“One of the big mysteries of #Huntingtons, #Alzheimer’s, and #ALS is why disease coincides with amyloid, yet the amyloids themselves are not the main culprits.” @HalfmannLab discusses new #research published in @eLife. Read here: bit.ly/43QTDUF #ScienceTwitter

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Halfmann Lab
Halfmann Lab@HalfmannLab·
@MadS100tist Ok Pickle. Months of head scratching and I think we finally know how the yeast are doing it. The awesome power of yeast cannot be contained!
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اكتشف

@arg_arginine @WuLabHarvard @UTSWMedCenter @ScienceStowers @IlyaVakser @TalIfargan @LostInTranscrip @ASAPbio_