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@MTSlive

Chronicling the singularity

mts.now انضم Mart 2026
659 يتبع141.7K المتابعون
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MTS@MTSlive·
SITUATION DETECTED: The New York Knicks are NBA Champions.
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SITUATION EXPLAINED: The Fable 5 shutdown. @hammondcheese, chief economist at FAI, live at Manifest: "The government introduced this 30-day review period for advanced models... Anthropic wanted to release a public version of Mythos. The government said, 'You can only do this if you can nerf these cyber vulnerability capabilities.'" "Amazon found a pretty narrow jailbreak... the government asked Anthropic to close it. There is no solution to the jailbreak that's 100% foolproof. And so in retaliation, they threw export controls." "It's extraordinarily unprecedented, not only export controlling you, but export controlling your ability to sell to the British."
MTS@MTSlive

SITUATION UPDATE: Anthropic confirms it is disabling Mythos and Fable 5 for all customers to comply with a US government export control directive. The company says it believes the order is a misunderstanding and is working to restore access.

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How did a middle schooler become the world's youngest prediction markets podcaster? @realTomBayes, live at Manifest: "My dad showed me prediction markets in 2024 right before the presidential election, we were looking at election odds." "In May of last year I was running for class president of my middle school, I saw some parallels there." "I asked ChatGPT, 'Prediction market but fake money and anyone can create a market', it said, 'Manifold. You should try Manifold Markets.'" "I made a Manifold market about, will I win my school's class president election... I did end up winning. But my school did not like at all that I made a prediction market about that."
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Trillions of dollars will be allocated based on who wins the AI race. @StephenGrugett, co-founder of @ManifoldMarkets & CEO of @MNX_fi: "The new company that I'm starting is an exchange focused on AI-related markets: GPU compute prices, electricity, and AI benchmark numbers." "Anthropic and OpenAI are about to go public... valued over a trillion dollars. The question of who will win the race to AGI will determine how trillions of capital is allocated." "And yet the most obvious question you would have about these AI labs is... who is gonna have the best model? What rate of progress will model improvement be at over the next year, two years, 10 years?"
MNX@MNX_fi

Trillions of dollars are flowing into AI, and there is almost nowhere to trade it. There’s no exchange for hyperscalers to hedge their $100M training runs. No benchmark markets to bet on the speed of AI progress. No public markets on OpenAI despite them being worth more than Goldman Sachs. The most important sector in the global economy has less financial infrastructure than soybeans. Until now. Announcing MNX, the first exchange to allow trading across the entire AI value stack, from H100 rental prices to Nvidia shares. Trade the takeoff at mnx.fi

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Peace through strength is the way forward for defense tech. @alexbronzini, writer at New York Magazine, live at Manifest: "Popular opinion in America is and has been for many years anti-interventionist." "But if defense tech can position itself as peace through strength, we are helping America build deterrence capability, we are helping America intimidate its adversaries such that they don't want to go to war against us, that could totally be a popular proposition." "This is somewhat the Anduril positioning... we're going to develop the most powerful autonomous weapons so that all of our enemies are intimidated into oblivion."
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What is the most counterintuitive finding in learning science? @tracewoodgrains, founder of @educprogress: "One of the biggest barriers to effective learning is that often the more effective education is, the less people intuitively like it... effective learning is hard work. Effective learning is often unpleasant in a way that ineffective stuff is not." "There's this great video from Veritasium... they show people science videos that just tell them the right thing. Everyone says, 'This was clear. This was easy. I liked it.' And then you give them a test on it, and they retained basically nothing." "They automatically slotted it into whatever model they already have of the world... it fits with whatever mistaken conceptions they have, and they just get things wrong." "Whereas if you say, 'This is wrong, this is wrong, and now this is right'... students say, 'That was kinda confusing. That was unpleasant.' And then you test them, and they perform significantly better."
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SITUATION DETECTED: OpenAI has made the first ever beautiful tech billboards.
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WHITE PILL: Waymo has now driven 170M+ driverless miles in the same cities humans drive, with 92% fewer pedestrian injury crashes, 92% fewer serious-injury crashes, 85% fewer cyclist injury crashes, and 81% fewer motorcycle injury crashes.
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SITUATION UPDATE: Anthropic confirms it is disabling Mythos and Fable 5 for all customers to comply with a US government export control directive. The company says it believes the order is a misunderstanding and is working to restore access.
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SITUATION DETECTED: The Trump administration is placing export controls on Anthropic’s Mythos and Fable 5 models, blocking foreign governments, companies, and individuals from access, per Axios.
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SITUATION EXPLAINED: Why is effective compute growing so fast? • Hardware manufacturing improvements (Moore's Law): 1.5x per year, for six decades straight • Investment in compute hardware: 2.5x per year, bigger than Moore's Law itself • Combined, these two have driven ~4x per year growth in training compute for the last decade • Algorithmic efficiency improvements add another 3x to 6x per year on top of that @theojaffee: "Four, sixteen, sixty-four, two fifty-six, and it just keeps going and going."
MTS@MTSlive

SITUATION EXPLAINED: Effective compute for AI training is growing at roughly 10x per year. • "Effective compute" combines three things: more hardware, more spending on that hardware, and algorithms getting more efficient • Year 1: 1x. Year 2: 10x. Year 3: 100x. Year 4: 1,000x. Year 5: 10,000x • That's a 10,000x improvement in 5 years • A million x improvement in 7 years • A billion x improvement in 10 years • Epoch AI says 10x per year is on the low end of estimates, the actual rate may be higher and accelerating @theojaffee: "Do you understand how insane it is for anything to grow an order of magnitude per year?"

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SITUATION EXPLAINED: Effective compute for AI training is growing at roughly 10x per year. • "Effective compute" combines three things: more hardware, more spending on that hardware, and algorithms getting more efficient • Year 1: 1x. Year 2: 10x. Year 3: 100x. Year 4: 1,000x. Year 5: 10,000x • That's a 10,000x improvement in 5 years • A million x improvement in 7 years • A billion x improvement in 10 years • Epoch AI says 10x per year is on the low end of estimates, the actual rate may be higher and accelerating @theojaffee: "Do you understand how insane it is for anything to grow an order of magnitude per year?"
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White pills detected
Saloni@salonium

All of these were reported over the past month: • A new pancreatic cancer drug, daraxonrasib, that roughly doubles survival in late-stage disease • A precision lung cancer drug, lorlatinib, that kept 55 percent of patients progression-free after 7 years, versus 3 percent on the old drug • A prostate cancer drug, talazoparib, that halves the risk of progression • An endometrial cancer drug, dostarlimab, where 58 percent of patients hadn't progressed after 4 years, versus 16 percent on chemo alone • An early-detection blood test, the NHS Galleri test, that quadrupled cancer detection but missed its main goal • An mRNA cancer vaccine that halved the risk of melanoma recurrence when added to Keytruda • The most effective weight loss drug so far, retatrutide, which cut body weight by about 28 percent • The first in vivo gene editing therapy, which cut hereditary angioedema attacks by 87 percent from a single injection • A one-time gene edit, VERVE-102, that lowered LDL cholesterol by 62 percent • A feat of pharmaceutical synthesis that raised enlicitide's manufacturing yield 14-fold using engineered enzymes • A functional cure for hepatitis B, bepirovirsen, that cleared the virus in about 20 percent of patients • The discovery that human cells can swap chromosome-sized DNA through nanotubes • An ancestor of CRISPR, VIPR, found in bacteriophages, that silences genes without cutting DNA • A preventive Covid-19 pill, ensitrelvir, that cut symptom risk by 67 percent after exposure • The first PROTAC drug, vepdegestrant, which destroys a disease-causing protein rather than blocking it Every month, Niko and I write a round up digging into the latest news in biotech and medicine, and this month's was astonishing. We share some thoughts on what's responsible for this progress and what it means for science in the future.

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Every consumer product has to rethink its interface. @andyfang, co-founder of DoorDash: "For the first time ever, agents are more web traffic than humans, whether we like it or not, we need to figure out a way to change our interfaces." "I used to think exactly the same way Brian Chesky did, I don't want a conversational experience in the product for consumers." "But people's behaviors are changing, Google has publicly stated that search query lengths have only gone up over the past couple years. People are trying to speak to it like a human versus translating what's in their head into keywords." "We've grown up doing that keyword translation for decades, we just assumed that's the most natural way to interact with computers. But now that these AIs are here, people are just trying to speak to it like a human." @julesrosenberg
Andy Fang@andyfang

Today we’re launching Ask DoorDash — a new conversational way to search the app in your own words through chat, voice, a recipe link or photo. Ask DoorDash can build you a grocery cart ~5x faster than doing it manually. It takes a single prompt to complete your cart in under 2 minutes. In early testing, nearly half of all restaurant orders made with Ask DoorDash were from a place the customer had never ordered from before, and grocery baskets built with Ask DoorDash were over 35% larger than those without. [1/3]

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SITUATION REMEMBERED: 9 years ago today Google researchers published a paper titled “Attention Is All You Need” introducing a new deep learning architecture known as the transformer.
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Good morning
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