Saur Lab

Tissue-specific basis for cancer evolution, as demonstrated with KRAS mutations nature.com/articles/s4158…

Our work is now published in @Nature. We introduce the Mouse Cancer Cell Line Atlas (MCCA) and reveal deterministic, tissue-specific rules of KRAS-driven cancer evolution. Huge thanks to the entire team & collaborators. nature.com/articles/s4158…

Join us in London in July next year!

Details of the inaugural @CR_UK #PancreaticCancer conference to be held in London (7-9 July 2026) below. Early bird registration closes on Jan 9. Abstract submission deadline March 15. cancerresearchuk.org/for-researcher… Share widely and hope to see you all there! 🇬🇧

Prof. Eric Topol at Helmholtz Munich: Exploring the Virtual Human 👉 t1p.de/5wthc Prof. @EricTopol, internationally renowned cardiologist, geneticist, and digital medicine expert, visited #HelmholtzMunich for a roundtable on the future of #AI in healthcare. ✨ The discussion focused on the concept of the #VirtualHuman, showing how AI can connect imaging, molecular, and clinical data to build detailed models of the human body. At Helmholtz Munich, the Virtual Human is being developed as an integrative multiscale basis model to represent patient journeys holistically. ✨ #FoundationModels were also highlighted, showing how AI can spot patterns in complex data and generate insights for more personalized and predictive healthcare. 👩‍🔬👨‍🔬 The event, a prologue to the Bavarian Conference on AI in Medicine, brought together leading experts: Prof. Topol, Prof. Martin Hrabě de Angelis, Prof. Fabian Theis, Prof. Ewa Szczurek , and Prof. Julia Schnabel, moderated by Dr. Annalisa Marsico. 💡 Helmholtz Munich provides an ideal environment for this research, combining advanced technology, rich datasets, and a collaborative ecosystem for developing digital human models. 💭 The event ended with a Q&A and a trainee lunch, giving early-career scientists the chance to engage with Prof. Topol and explore new directions in AI and health research. @fabian_theis @ewa_szczurek @ja_schnabel @lisamar2017 @CompHealthMuc #AIinMedicine #DigitalHuman #PrecisionMedicine #Healthcare 📷©Stefanie Winkler | Helmholtz Munich

Tue #pancreatic #organoids presented at CIPCC by Jonathan. Beautifully recapitulation of development reaching full architectural and cellular heterogeneity. Branching ductal tree, functional acinar cells and endocrine cells. The opportunities are endless. biorxiv.org/content/10.110…

So many RAS inhibitors! @andrewaguirremd speaks at @BottonChampPanc #PancreaticCancer symposium. Important to note 1st line shows better efficacy than 2nd line, arguing for moving the drugs earlier in disease process.

The New York Munich Goettingen crew has landed in Lisbon for @BottonChampPanc #PancreaticCancer research meeting! @SaurLab @MaxReichertMD @ChiaraFalcomata @BarbaraGrnwald

🚨Registration is now open for the Cancer Research UK Pancreatic Cancer Conference 2026!🚨 Join me and my conference co-chairs @Aiims1742 @SaurLab for the inaugural meeting in London, UK, from 7-9 July 2026, hosted by @CR_UK. 💜 Find out more: cruk.ink/47nQbDL

Enjoying the @EurPancClub Think Tank on #PancreaticCancer very much! Here with @rkalluriMDPhD @Val_LeBleu @mvh_lab and many others in Munich. Thank you Ekin Demir @TU_Muenchen for organizing!

Lots of activity in the KRAS targeting space but always a pleasure to hear @Val_LeBleu talk about @MDAndersonNews “farm to table” in-house iExosome effort, sans ANY toxicity in patients & with great target engagement data. Read the phase 1 paper here: nature.com/articles/s4146…

Honoured to join experts at the #G7Cancer conference in Paris on June 26, organised by #INCa & NCC Japan. Proud to represent our work at @crcm_marseille & @paoli_calmettes Replay here 👉 g7cancer-events.com/live/

Yoshi Majima (founder of @PanCAN Japan) has been a passionate advocate for patients & families for over two decades. He talked about his own experience with surveillance and early detection of #PancreaticCancer. From the G7 Cancer Conference on Poor Prognosis Cancers (Paris).

New preprint out! 🚀Spearheaded by @ChiaraFalcomata we could show how pancreatic cancer cells evade the immune system by modulating their TME with the extracellular factors Serpine1 (PAI-1) and Serpinb2 (PAI-2)! #PertrubMap #PDAC

📣Coming Soon: Extracellular Vesicles and Exosomes Biology Core Facility (EVcore) A first of its kind facility to support your EV research needs including isolation, characterization, imaging, engineering and more. Grateful to @CPRITTexas for supporting this resource. Stay tuned for more information! cprit.texas.gov/grants-funded/…

The coagulation cascade has always had an interesting relationship with #PancreaticCancer. Here @ChiaraFalcomata demonstrates the role of two fibrinolysis inhibitors in sculpting the tumor micro environment. These genes were identified using PerturbMap. biorxiv.org/content/10.110…

🚨 Our new #preprint is out! doi.org/10.1101/2025.0… We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)

@ChiaraFalcomata Congratulations Chiara for the amazing work using PerturbMap for the first time to study immunosuppressive PDAC TME regulators with great translational potential!

🚨 Exciting Opportunity for Master’s Students!🚨 We’re looking for two motivated Master’s students to work on #CRISPR screening projects in #PDAC. 📧 Interested? Send your application to: abdallah.gaballa@tum.de We look forward to your application! 🚀

Thrilled to share that our paper nature.com/articles/s4158… is featured in a fantastic Nature News & Views piece by @ThomasTueting! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. nature.com/articles/d4158… 👀👉 rdcu.be/d3cRz