Saur Lab

🎉 Very happy to have had the opportunity to contribute to this latest @DiseasePrimers #Review on #PancreaticCancer together with a number of great colleagues! @ednacukierman @EileenMOReilly @SaurLab @BarbaraGrnwald ... Hope it is a useful read! 😊💜 nature.com/articles/s4157…

Phoenix 🐦‍🔥 works zero-shot (out-of-the-box) on unseen cohorts, patients, organs, and tissues — no fine-tuning needed. This is the start of a real shift in how we'll use pathology archives. Hypothesis generation at this scale opens up questions we couldn't realistically ask before, especially in understudied tissues and subtypes.

Very timely @DiseasePrimers article on #PancreaticCancer given all the "buzz" about advances in this disease last few weeks. nature.com/articles/s4157…

1/7🎉 Introducing Phoenix: generative AI predicting spatially resolved gene expression from routine H&E slides-enabling virtual spatial-omics. Zero-shot. Across cancers, organs & species. Huge thanks to my co-first @TranManuel & all collaborators! 🙌 📜: doi.org/10.64898/2026.…

Thrilled to share Phoenix: virtual spatial transcriptomics from routine H&E in >10k patients. Led by @TranManuelD & @rushin_gindra with @p_tingying & @fabian_theis. Predicts gene expression across #PDAC & rare cancers—toward biomarkers and therapy response doi.org/10.64898/2026.…

📣 Last Tuesday, 28 April, we proudly celebrated 10 years of PCE! A milestone evening in Malta, supported by the Ministry for Health and Active Ageing (Malta), bringing together partners, advocates, researchers & policymakers. A decade of progress, a united voice for patients across Europe. 💜

Houston, we have a solution! @SaurLab and @Bingruilii are on the scene at NASA 🚀 Glad to have Dieter with us in Houston for a terrific week of science!

@KalluriLab @Bingruilii Thank you for hosting me and for a few days of inspiring science and fun!

Thrilled to host the inimitable Dieter Saur (@SaurLab), Professor at @TU_Muenchen & Head of Translational Cancer Research at @DKFZ, for the Stadtler Endowed Distinguished Lectureship at @UTMDAnderson. Dieter set the record for attendance 📈 on his very first trip to Houston. A historic day for science in Space City 🚀

Honored to deliver the Stadtler Endowed Distinguished Lecture at @UTMDAnderson to an exceptional audience. It felt like #AACR for #PDAC and #RAS all in one place. Thank you, @rkalluriMDPhD, for hosting me and for your leadership in building a truly world-class cancer program.

@rkalluriMDPhD @TU_Muenchen @DKFZ @UTMDAnderson Many thanks, Raghu, for the warm welcome. I was truly impressed by the institute, two inspiring days with 30 faculty members and trainees, as well as the chance to explore Space City and visit NASA.

Excited to share our cross-species PDAC atlas preprint led by D Lucarelli & S Parikh in collab with D Saur: biorxiv.org/content/10.648… 1.6M single cells (human + mouse) to quantify how well models capture disease 🧬 Core programs are conserved, even rare immune pops clearly aligned.

Massive cross species single cell atlas (>1.6 million cells) of #PancreaticCancer, including early and advanced, metastatic disease, as well as post therapy states. Incredible resource! Preprint from @SaurLab @fabian_theis biorxiv.org/content/10.648…

Tissue-specific basis for cancer evolution, as demonstrated with KRAS mutations nature.com/articles/s4158…

Our work is now published in @Nature. We introduce the Mouse Cancer Cell Line Atlas (MCCA) and reveal deterministic, tissue-specific rules of KRAS-driven cancer evolution. Huge thanks to the entire team & collaborators. nature.com/articles/s4158…

Join us in London in July next year!

Details of the inaugural @CR_UK #PancreaticCancer conference to be held in London (7-9 July 2026) below. Early bird registration closes on Jan 9. Abstract submission deadline March 15. cancerresearchuk.org/for-researcher… Share widely and hope to see you all there! 🇬🇧

Prof. Eric Topol at Helmholtz Munich: Exploring the Virtual Human 👉 t1p.de/5wthc Prof. @EricTopol, internationally renowned cardiologist, geneticist, and digital medicine expert, visited #HelmholtzMunich for a roundtable on the future of #AI in healthcare. ✨ The discussion focused on the concept of the #VirtualHuman, showing how AI can connect imaging, molecular, and clinical data to build detailed models of the human body. At Helmholtz Munich, the Virtual Human is being developed as an integrative multiscale basis model to represent patient journeys holistically. ✨ #FoundationModels were also highlighted, showing how AI can spot patterns in complex data and generate insights for more personalized and predictive healthcare. 👩‍🔬👨‍🔬 The event, a prologue to the Bavarian Conference on AI in Medicine, brought together leading experts: Prof. Topol, Prof. Martin Hrabě de Angelis, Prof. Fabian Theis, Prof. Ewa Szczurek , and Prof. Julia Schnabel, moderated by Dr. Annalisa Marsico. 💡 Helmholtz Munich provides an ideal environment for this research, combining advanced technology, rich datasets, and a collaborative ecosystem for developing digital human models. 💭 The event ended with a Q&A and a trainee lunch, giving early-career scientists the chance to engage with Prof. Topol and explore new directions in AI and health research. @fabian_theis @ewa_szczurek @ja_schnabel @lisamar2017 @CompHealthMuc #AIinMedicine #DigitalHuman #PrecisionMedicine #Healthcare 📷©Stefanie Winkler | Helmholtz Munich

Tue #pancreatic #organoids presented at CIPCC by Jonathan. Beautifully recapitulation of development reaching full architectural and cellular heterogeneity. Branching ductal tree, functional acinar cells and endocrine cells. The opportunities are endless. biorxiv.org/content/10.110…

So many RAS inhibitors! @andrewaguirremd speaks at @BottonChampPanc #PancreaticCancer symposium. Important to note 1st line shows better efficacy than 2nd line, arguing for moving the drugs earlier in disease process.