Dimethyl

@bryan_johnson How is shrooming TWO times enough data to make this conclusion. Replicate at least 10 times with perfect consistency. U did TWO. TWO.

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

@ZssBecker is becker still rich. who knows

Awww good. Back below 70k. I was getting tired of having hope and believing I would escape crippling poverty any way. Hoo. Rah. Off to drink some draino.

@stoicsavage not locked enuf n not getting the context to half ur tweets

Remember the kinds of pumps these tweets used to create? We had some good times.

@levelsio Sure if ur solo traveling... which gets old after like 1 year. And i gaurantee ur not gonna wanna settle in any of these 3rd world countries. So if you want a dope life you need a home base in a walkable city with lots to do which means you need money and a lot of it

Even bigger irony of getting rich is that everything expensive isn't that much better than when you paid normal for it Many things are even worse (most expensive luxury hotels are guaranteed worse than regular simple hotels, I know I tried most of them now) The real reason you wanna get rich is not to buy expensive things It's so that $1M invested gives you 3% to take out every year with no risk, which is $30,000/year Which you can use to travel for $1000/mo on a shoestring budget forever without having to back to some desk job with a shitty boss Aka FREEDOM

@Innerdevcrypto 16 years of hard work / discipline one shotted by oh shit I like beer and pizza. Good lesson tbh

Best visit recently ever was from a guy who had been a vegan 10 years, followed by another 6 years of keto, out of which at least 10 years where serious inner searching as well Results, basically nothing, since he still had not resolved his struggles and was filled with anxiety. He kept insisting he wanted to see me, so i said, ok, fine I told him, just do what i do tonight: we had beer, pizza, and went dancing I know...it sounds insane After a couple of beers, he told me about his intense frustration with everything, at the end he was even crying, tears of frustration and joy, and the next day he understood what i did He doubled down on his inner search, and finally his mind collapsed 3 months later and he found total clarity by finally giving up (funny enough, that is how it works, victory is achieved by giving up when the mind has exhausted all avenues, that is when clarity appears, no more resistance. In fact total victory = total failure) This time this was the right approach, other times when undisciplined people visit a long fast in the dark might be the right solution or some brutal discipline, but some people are just stuck in the same old pattern and are getting nowhere, so jolting them out of it is only accomplished by doing the exact opposite, which this time was beer & pizza His last message was: ¨thank you, i never forget you gave me the most profound realisation how stuck i was through drinking beer and eating pizza¨ I love my ¨job¨

All of CT longing bitcoin all at the same time again

@JShodanVR it looks like it takes an hour to set up, annoying to wear and you cant take big steps

I don’t understand. This stuff is real, it exists, you can actually buy it, and yet the VR market is almost dead. What happened to the kids in the 90s who dreamed about this possibility? Why do modern kids now go crazy for games where you don’t really do anything, where at most you just swipe up and down, or spend their time screaming in stupid games that require no concentration, like amoebas with no curiosity? This stuff finally f***ing exists, and yet the videogame market pretends it’s invisible. F***! F***! F***! In 1998, when we were 13 playing Resident Evil 2 on the PlayStation with my friends, we would have killed to be able to play something like this. Credits: @VirtuixOmni here’s their YT channel: youtube.com/watch?v=Evyjom…

@KimDotcom There is simply more scum that stays perpetually online to answer polls like this than not

3 hour poll. Do you want the Jews kicked out of America?

@sonder_crypto Lold

Sickkk tweet after a month of silence

@ayushtweetshere @ImNotTheWolf Why is everyone working more. AIs supposed to help you work less

Every smart person I know is working 10-12+ hours a day every day.. Even weekends.. And they're mostly tinkering with AI.. Exploring new tools, prompts, workflows.. We're living in unprecedented times in history... The rate of growth has never been this fast in any domain.. And the opportunity to build something incredible WHILE having fun has never been so obvious...

Have a lot of friends that still work in SAAS and I'm shorting their companies stocks

@degenvestor69 Jordi visser hrv substack is amazing Ill just suggest the one to not overwhelm for now

@dTrypt good substack recs?

4 things ive done that drastically improved my mental health recently: -20 mins morning sunlight on my roof deck every morning - lift heavy weights again (I was injured, had surgery) - replaced time on X with substack where good articles are paywalled and higher effort -stopped trading completely (not even unprofitable just lost meaning) Time spent trading replaced with building a model of my strat with openclaw that should run autonomously soon. May expand upon this later.

@bub_bobino @bilbo6910 12

@bilbo6910 @dTrypt could be 24 🌚

Today is Chinese/Lunar New Year and everyone is in an arms race to build the best version of an AI-integrated future. How fitting that it's the year of the horse. I believe it will be the most impactful year of our lives. Time to adapt or die, and let go of what's not serving you... It's also my year (horse)

@lexfridman If you don't have a clean slate computer for each iteration of openclaw or the like then you are simply retarded and deserve to loose it all

The power of AI agents comes from: 1. intelligence of the underlying model 2. how much access you give it to all your data 3. how much freedom & power you give it to act on your behalf I think for 2 & 3, security is the biggest problem. And very soon, if not already, security will become THE bottleneck for effectiveness and usefulness of AI agents as a whole (1-3), since intelligence is still rapidly scaling and is no-longer an obvious bottleneck for many use-cases. The more data & control you give to the AI agent: (A) the more it can help you AND (B) the more it can hurt you. A lot of tech-savvy folks are in yolo mode right now and optimizing for the former (A - usefulness) over the the latter (B - pain of cyber attacks, leaked data, etc). I think solving the AI agent security problem is the big blocker for broad adoption. And of course, this is a specific near-term instance of the broader AI safety problem. All that said, this is a super exciting time to be alive for developers. I constantly have agent loops running on programming & non-programming tasks. I'm actively using Claude Code, Codex, Cursor, and very carefully experimenting with OpenClaw. The only down-side is lack of sleep, and an anxious feeling that everyone feels of always being behind of latest state-of-the-art. But other than that, I'm walking around with a big smile on my face, loving life 🔥❤️ PS: By the way, if your intuition about any of the above is different, please lay out your thoughts on it. And if there are cool projects/approaches I should check out, let me know. I'm in full explore/experiment mode.

We're cooked, chat.