Garg Lab

Congratulations to 3 physician-scientists at Yale for receiving research grants from @AmericanCancer! ▪️Mark Lee, MD, PhD @Yale_LabMed, a Yosemite-ACS Award ▪️Benjamin Lu, PhD, Clinician Scientist Development Grant ▪️Salil Garg, MD, PhD @garg_lab, a Discovery Boost Grant bit.ly/4sgqiht @SmilowCancer @YaleMed @YNHH

Deeply honored for our laboratory to receive a NIH Director's New Innovator Award from @NIH_CommonFund. Delighted to see what we can learn about the origins of heterogeneity in cell systems over the coming years! #NIHHighRisk

@_SumanB @NIGMS @MayoClinic Great job and congrats Suman!! Hope all is well at Mayo!

Grateful to receive the #R35 #MIRA Award from @NIGMS, which will support our work on developing safer and more effective cell therapies at @MayoClinic. If you are excited about cell therapies, biomaterials, or bioelectronic implants, take a look at our lab and consider applying!

@srviswanathan @CellCellPress @DanaFarberNews Wow Srini, very cool study!

Our study on sex differences in Xp11 translocation renal cell carcinoma is out @CellCellPress! We ascribe a genetic basis to the female bias in tRCC, which is driven by a translocation of the TFE3 gene on the X chromosome. w Zhang lab @danafarbernews bit.ly/4dtpNtP 🧵1/

@peiferlabunc @Nature Indeed, I can't comment fully on others. But for example, this paper reflects an idea I brought to him to work on as a postdoc, and continued after I transitioned to a fellows role: pnas.org/doi/full/10.10… He let me choose order/corresponding (though we did discuss).

@peiferlabunc @Nature I just became aware of this post today. If this is about Phil, he is super generous. For the last several years, senior postdocs (I was one) choose the corresponding. Phil gives complete freedom to work on what you want, and reflects that in delegating these decisions.

Congratulations to Dr. Timothy Robinson, @kenleonloh, @garg_lab, and @MonicaValero16, recipients of 2024 ACS-IRG Pilot Grants. @SmilowCancer @YaleMed @YNHH @americancancer

@TuomasTammela @StefanTorborg Tuomas this is very cool. Score another one for cell-cell circuits!

@StefanTorborg caps off 2023 with a study where he finds cancer cell states organize into and maintain a carefully controlled equilibrium in solid tumors. Surprisingly, perturbing the mechanisms controlling this equilibrium suppresses tumor growth. biorxiv.org/content/10.110…

Lab Med had a wonderful visit with Heidi @Yale PD's service dog 🐕‍🦺 Big thanks to Heidi's handler Officer Rich Simons who was eager to share Heidi with us! Check out our #SmilesForMiles😃 Go fetch Heidi & Officer Simons by following #OfcHeidi_YalePd on Instagram.

Our Genetics, Genomics, and Epigenetics Program welcomes Dr. Salil Garg @garg_lab, as Assistant Professor of Laboratory Medicine and Pathology. @Yale_LabMed @yalepathology @SmilowCancer @YaleMed @YNHH

Very honored to receive a Charles Hood Foundation Child Health Award! We will be working on discovering the developmental origins of pediatric tumors, and using this information for diagnosis. charleshoodfoundation.org/portfolio_page…

@sdomcke Congrats. Very interesting - I had always assumed the indirect, higher order effects were dominant but these results add evidence that the encoding is more directly the TF reading out the sequence space (along with its modifications).

Transcriptional control by methylation-sensitive TFs could benefit the expansion of ERVs by being compatible with expression in hypomethylated states in the germline while ensuring repression in somatic cells. 6/6

Excited to see my final PhD work published @NatureGenet (rdcu.be/c02lQ)! How does DNA methylation repress genes? Through direct inhibition of transcription factor (TF) binding at the motif OR indirect inhibition via sequence-independent recruitment of MBD proteins? 1/6

In the November issue— Developmental Deconvolution for Classification of Cancer Origin, by Moiso, @garg_lab et al. bit.ly/3AjLpHN @MIT @kochinstitute @broadinstitute @MGHPathology #cancerofunknownprimary

@DigbijayMahat Congrats Jay!! So well deserved, and we are very proud of being one of your collaborators!

Honored to share the 2022 STAT Wunderkind award with an incredible cohort of young scientists!

@WilenLab If there was a "super-like" button I would click it! 😁

@garg_lab Sounds like a great opportunity for students and postdocs!😉

Happy to share our latest, online @MolecularCell. In order to form different cell types, stem cell systems need to drive cell-to-cell variation in gene expression. But do the instructions always come from outside the cell, or can they be self-encoded? If so, how? (1/10)

@mitomaths This is very interesting, thank you for sharing! I wasn't aware of this but it makes sense germination would also have an encoded intrinsic motif for generating variability between seeds. Haven't considered metabolic circuits in ESCs but would be interesting to do so.

@garg_lab This popped on my feed; congrats on a really interesting looking study! The broader motif of antagonistic influences inducing variance (while preserving mean) generates useful variability in germination time in plants (via hormones, not TFs) royalsocietypublishing.org/doi/full/10.10…

Interested in non-genetic heterogeneity in development and cancer? Garg lab (garglab.org) is recruiting at multiple academic levels! (please RT) @Yale_LabMed @YaleRNA Postdoctoral associate info here: postdocs.yale.edu/postdoctoral-a…

The work was led by @HarvardMITmdphd student Sofia Hu working alongside many other members of @garg_lab and a great team, including collaborators Abhyudai Singh, Jacqueline Lees, and @DigbijayMahat. @YaleRNA, @Yale_LabMed (10/10)

Many, many open questions, including how transcription factors and enhancer RNA interact, how the same factor can have activating or repressing effects depending on context, and how the system is wired together to allow particular cell states and disallow others. (9/10)