Ken Loh

@Shuo_Han_ @Nature Congratulations!!!!!

Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. nature.com/articles/s4158…

ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on @Addgene addgene nature.com/articles/s4159… Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators, @blsabatini @Kanoski_Lab @vincentw_weng @beherring

@katenokv Congratulations!!!!

Great news for the lab! We are excited to become part of #CZBiohubNY . Looking forward to connecting with other investigators and group leaders in the Biohub!

This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved. @Eric_E_Zhang @susanksgolden @ @SRBR_Outreach rdcu.be/efxV8

Tardigrades are small invertebrates renowned for their resistance to harsh environmental conditions, including ionizing radiation that would kill many organisms. By studying a newly identified species of tardigrade, researchers in Science have gleaned valuable insights into the animal’s ability to withstand radiation. bit.ly/3Up3RIZ

Scientists have designed a new form of insulin that can automatically switch itself on and off depending on glucose levels in the blood go.nature.com/3A14Yrk

An enzyme that can synthesize aromatic azides! Bioorthogonal no more? 😝 Cool paper in @NatureChemistry by Wenjun Zhang & colleagues @UCB_Chemistry nature.com/articles/s4155…

📢For all HaloTag lovers💙💚❤💜🤍 we developed a new cell-permeable Biotin-HaloTag ligand enabling rapid protein labeling in living cells and efficient streptavidin pull-down. We hope you enjoy the reading and find some inspiration🙌 biorxiv.org/content/10.110…

As a key developer of tissue clearing tech, I must congratulate the authors on this groundbreaking work. This paper opens the door to 4th gen tissue clearing technology. Trying a brief overview: #TissueClearing #Neuroscience 1/n science.org/doi/10.1126/sc…

Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday nature.com/articles/nmeth…

@echouchani @HHMINEWS @DanaFarber @HarvardCellBio Congrats!!

I am thrilled and honored to join the @HHMINEWS community. So grateful to my lab, colleagues at @DanaFarber @HarvardCellBio, and collaborators whose work this reflects!

A thread acknowledging the many contributions of the @UCSF @UCDavisHealth team for our study, out online at go.nature.com/3S0vrLC 1/7—We identify a new hormone, CCN3, produced in the hypothalamus to build bones and offset bone loss during lactation - a 5-year journey. One cover idea 👇.

@AndersMNelson @klingensteinorg Congrats!!

Thank you @klingensteinorg for your generous support! 🙏

@xinjin Congrats Xin!!!!!

Grateful to @McKnightFdn @PewTrusts and the supportive, stimulating environment at @scrippsresearch. Huge thanks to my wonderful and endlessly creative lab members — you make coming to work a daily joy and privilege. Did I say this enough:🌟 We’re actively hiring! 🌟

@doristsao Congratulations!!

It's hard to express how grateful and unworthy I feel to receive this honor. It feels embarrassing to be distinguished for discoveries that depend on the contributions of so many. I thank my mentors Marge Livingstone and David Hubel for their love and faith. I thank the students and postdocs in my lab for their creativity, brilliance, and perseverance. The greatest gift is to be able to dream together with them. I thank the field of macaque systems neuroscience for giving me my life as a scientist. I believe this award recognizes the irreplaceable role of our field in advancing understanding of the brain. It is especially gratifying to receive this together with @Nancy_Kanwisher, one of my scientific heroes. The story of how the brain represents faces is an ongoing dialogue between human and macaque neuroscience--a dialogue that has just begun. Though I started on this path by accident, I have come to realize that the humble problem of perceiving a face is a microcosm of the problem of perceiving the world.

Excited to share our work out today at @Nature. We built on the proximity labeling technique to establish PhagoPL, a novel tool to study the protein composition of phagosome containing real and intact microbes! link.springer.com/10.1038/s41586…

We are excited to share our latest preprint on a new solution to next-generation peptide/protein sequencing. Peptide sequencing via reverse translation of peptides into DNA biorxiv.org/content/10.110…

Just out @Nature The 1st whole-slide digital pathology #AI foundation model pre-trained on large-scale real-world data, from over 1.3 billion images, 30,000 patients nature.com/articles/s4158… @hoifungpoon @HanwenXu6 @Microsoft @UW @naotous @MSFTResearch

Our new paper "GLP-1-directed NMDA receptor antagonism for obesity treatment" is out today in @Nature nature.com/articles/s4158… We describe the engineering and preclinical development of a new drug candidate that targets NMDA receptors in GLP-1 receptor neurons. 1/8 🧵👇