Craig Wilen

1/ Thrilled to share a Perspective that summarizes 30 years of work from the many labs studying the human genetic and immunological causes of infectious diseases: doi.org/10.70962/jhi.2…

BREAKING🔔 Our new study is out at @biorxivpreprint. We established a novel animal model for SARS-CoV-2 infection using horseshoe bats, a natural reservoir of SARS-CoV-2-related coronaviruses in nature. Please repost🦇 biorxiv.org/content/10.648…

HIV joining the circular RNAs Club ? Welcome ! nature.com/articles/s4156…

Congratulations to @SteitzLab ! 🎉🎉🎉

Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy

Excited to share our new paper in @CellCellPress with @MarcoRuella, led by @Shan_Liu_ and @PuneethGuru_. CAR T cell therapy loses effectiveness over time due to metabolic exhaustion, but we found a surprisingly simple approach to address it. 👇 cell.com/cell/abstract/…

Congratulations to Dr. Pena-Hernandez @marioph13 on his outstanding thesis defense today! We couldn’t be more proud! Both the Wilen and Iwasaki labs will miss you. @VirusesImmunity @Yale_LabMed @YaleIBIO

Increasing evidence that STING has functions beyond DNA viruses. A new study reports that STING restricts influenza infection, independently of IFN. This work complements prior studies that STING prevents infection with diverse RNA viruses. science.org/doi/10.1126/sc…

New study from Wade Schulz, MD, PhD (left) & @ThomasDurantMD of @YaleMed in @clin_Chem_ADLM evaluates performance of quantum machine learning algorithm—quantum circuits w/data re-uploading (QC-REUP)—compared to classical machine learning & other QML methods rb.gy/y9mmj6

New in @JVirology: How does the human norovirus particle assemble? Particle assembly is facilitated by VP2 acting as a molecular bridge. We also share intriguing features making pandemic HuNoV VP2 unique in structure and sequence. journals.asm.org/doi/10.1128/jv…

Grea paper. Congrats to the Lee lab @Yale_LabMed

A nice write-up from Nature Immunology about our recent paper! nature.com/articles/s4159…

I'm trying to train Claude to read the weekly emails from my kids school and reliably summarize them and print a list of action items. It is losing its damn mind and rapidly spiraling into madness. I feel vindicated

On the balance of knowledge dlvr.it/TQnN9N

⚠️ If you’re reading this, you’ve been infected* ⚠️ *~95% the human population has been infected by the Epstein-Barr Virus (EBV). Today in @Nature with @nyeo_sherry, @EMC22381830, @RyanDhindsa @SlavePetrovski, we shed some light on what happens next. nature.com/articles/s4158…

Happy to share our new paper @PLOSBiology on crosstalk between interferons and tissue repair. IFNs are critical for antiviral defense but excessive production is linked to delayed recovery. We found that at high concentrations, IFNs co-opt the downstream portion of the Hippo developmental signaling pathway to curtail epithelial repair and regeneration. Huge congrats to first author @krupa_subs and co-authors @YaleMed @Yale_LabMed @YaleIBIO journals.plos.org/plosbiology/ar…

Congratulations to @mnleeee, assistant professor of Laboratory Medicine @YaleMed, for being among 19 renowned researchers chosen for a prestigious research award from a partnership of @AmericanCancer & Yosemite, a venture capital firm dedicated to making cancer non-lethal. shorturl.at/K4IvB

Nice summary of our recent work on variation in common cold infections @WSJ wsj.com/health/cold-vi…

Rhinoviruses cause common colds & asthma attacks but are also often benign. Our latest paper delves into why--check it out at cell.com/cell-press-blu… Kudos to first author Bao Wang and team members @JulienAmat1, Valia Mihaylova, Yong Kong, & Guilin Wang @YaleMed @Yale_LabMed @YaleIBIO

Only 3 days left to apply for a Summer Internship in the Yewdell Lab. Don't miss out on the chance to gain exposure to what a job in "industry" actually looks like, and get a leg up towards advancing your career. Apply now! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…