Emin Bursa

Today I'm announcing a protein compute web service: subseq.bio It's a simple web tool to submit compute-intensive tasks related to protein design, and biotechnology jobs. You can select from state-of-the-art, open source protein ML models, pre-configured and can begin running within minutes. Currently supported are RFdiffusion, and Alphafold (v2), with more coming. There are no restrictions on your output data. Just select the program, enter program arguments, and an optional upload folder, and click submit. Download the output data when finished. It is pay-per-use: Jobs are charged from your account credits when submitted. You can top up credits easily, any time. Currently jobs cost between 5¢ - $1. Feedback is important! Let me know ways it can be improved. More features are coming. For detailed updates please follow @subseqbio

Best of luck to the artemis 2 astronauts!

@subseqbio @open_fold 😀

🪅Update: OpenFold-3 is now available on subseq! "OpenFold3-preview is a biomolecular structure prediction model aiming to be a bitwise reproduction of DeepMind's AlphaFold3" Source: github.com/aqlaboratory/o… This marks the 18th, and 5th structure prediction, program on subseq.

@brad_woolf I think regulations in the US at least are a major contributor to this seemingly lack of sci-fi biotech - but I think the costs, and the tech is building up and the regulatory dam will break soon

@deepfates you can in cli

Wait you can't compact manually in codex? wtf

@danaparish ... and?

My friend w Long Covid since 2022 just went on a month of doxycycline (a first-line Lyme antibiotic) for a stye on her eye & called me, “all my Long Covid symptoms went away! Have you ever heard of something like this??” Well, yes….

@Alibaba_Qwen something ain't right with these people

Demo5： Voice Style, Emotion and Volume Control

@DilumSanjaya oh that UI is inspiring

Vibe Coding Robotics Part 10 Added a secondary camera focused on the gripper Next : generating CAD scripts to explore more advanced gripper mechanisms Code : Gemini 3.1 Pro Design : Nano Banana

@design_proteins I have liked using TeselaGen OpenVector Editor github.com/TeselaGen/tg-o…

Haven't designed primers in a while, what tools are people using these days? Any recommendations?

@digitalix v100s, 32gb vram, 900gb memory bandwidth, cuda

32GB of VRAM for under $1000! The Intel Arc Pro B70 just landed.

@littmath I think it all comes down to architecture - a lot of recent research has shifted to MoE and coding capability, not general intelligence

Given what current-gen LLMs (say, in math, but whatever) can do, I think their apparent limitations are kind of mysterious. What is the blocker preventing, at present, high quality fully autonomous work?

Proteins can now talk. Introducing BioReason-Pro, the first reasoning model for protein function. A thread🧵

@TheAhmadOsman whats your thoughts on those devices - all in? or nah

was invited to the Tenstorrent office yesterday, enjoyed hearing about all the things they’re working on & saw some really cool hardware

@JaydevTonde watcha doin with those?

8*H100

@miangoar 😅

The proteinologist community trying to follow up on the papers of OpenFold3 x.com/MoAlQuraishi/s… 31M complexes added to the AlphaFold DB x.com/pushmeet/statu… Proteina-Complexa testing 1M binders in the lab x.com/DidiKieran/sta… x.com/ManifoldBio/st…

@VibeCoderMcSwag you did not do manual coding before vibe coding, and now you are only doing manual coding?

i started as a vibe c0der and now i'm just a coder

@NousResearch 👏 seems good 😍

Meet Hermes Agent, the open source agent that grows with you. Hermes Agent remembers what it learns and gets more capable over time, with a multi-level memory system and persistent dedicated machine access.

@ATinyGreenCell Feel free to give @subseqbio a try 😀

Any recommendations for an arbitrary de novo protein design tool that's ideally free? Every time I see de novo protein design it actually is antibody or binder design. I need it for things that have nothing to do with medicine. TYIA!

@lemire wow I can't believe 35% all hand code

What fraction of your code is typed by hand (no AI)?

@vllm_project @openclaw fix gguf support

Want to run @openclaw with your own model using vLLM? 🦞 It is surprisingly easy and fast: 1️⃣ Deploy the model with vLLM 2️⃣ Expose the OpenAI-compatible API 3️⃣ Point OpenClaw to the endpoint Tool calling works out of the box, so it plugs nicely into OpenClaw agent workflows. vLLM setup guide (using Kimi K2.5 from @Kimi_Moonshot as an example): docs.vllm.ai/projects/recip… Quick Demo 👇