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Manifold Bio
98 posts
Manifold Bio
@ManifoldBio
Organism-scale intelligence, designed in vivo
Boston, MA Katılım Şubat 2019
19 Takip Edilen1.8K Takipçiler
@adpdnet Underlying this work, and central to Manifold's pipeline of tissue-targeted medicines, is our multiplexed in vivo screening platform that allows simultaneous assessment of tissue distribution across hundreds of receptor candidates in a single study.
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If you're at #ADPD2026, don't miss Naveen Mehta’s talk on @ManifoldBio’s approach to one of the core challenges in treating neurodegenerative diseases: getting drugs across the blood-brain barrier.
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The study between @ManifoldBio and @NvidiaHealth generated thousands of new annotated structures for future model training. and sets a new benchmark for matching the throughput of generative AI models with experimental validation at equivalent scale.
👉 research.nvidia.com/labs/genair/pr…
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This method was first demonstrated by @ManifoldBio last October. We tested 1.1M VHH antibody designs against 145 targets, measuring 100M+ protein-protein interactions to validate #mBER, the company’s AI library for designing epitope-specific antibodies.
👉 manifold.bio/news/introduci…
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@ManifoldBio and @NVIDIAHealth announce a joint study validating Proteina-Complexa, NVIDIA's latest BioNeMo model for protein binder design.
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Manifold Bio retweetledi
It’s no secret that @geochurch's lab has spawned dozens of biotech startups. The more interesting question is: what creates that level of momentum?
@glebkuz left Google to join the Church Lab. Today, he’s CEO at @ManifoldBio. He and his labmates started the first wave of #AI-native biotechs, including two other companies from his lab bay alone: @Dyno_Tx and @nablabio.
On #Transcribed, Gleb reflects on career pivots, why the Church Lab was so special, and the unexpected moments (like giving George a ride from San Francisco to Mountain View) that changed his entire trajectory.
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Manifold Bio retweetledi
Fun podcast with @sajithw where I share the story of @ManifoldBio and my own journey as an engineer into the world of biophysics and now drug design.
Sajith Wickramasekara@sajithw
One of the biggest unsolved problems in making medicines is what comes after AI design. @glebkuz, cofounder and CEO of @ManifoldBio, is tackling the in vivo bottleneck. Screening hundreds of thousands of antibody designs in a single animal changes what’s possible in drug discovery. I’ve known Gleb since he was my TA at MIT, so it was really fun to have him on Transcribed. We talked about: - Why he left Google to start over in biology (literally showing up at @geochurch’s lab and asking how he could be useful) - How 3 companies came out of his grad school lab bay - What it takes to build a true platform company - Where AI-driven drug discovery is actually headed
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Manifold Bio retweetledi
🧬@ManifoldBio is on an “ambitious mission” & it’s getting there faster with the #AWS #GenAI Accelerator.
🎞The #startup’s Co-founder & CEO discusses how GAIA will fuel growth.
🚀Join us at AWS re:Invent & discover how to accelerate your company’s mission: go.aws/4oht3x4
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Manifold Bio retweetledi
New: Roche is paying $55M upfront, over $2B in pot'l milestones in a research deal with Manifold Bio
The two are working on better brain shuttles, or proteins that can cross the brain-blood barrier.
One of the larger pharma pacts of 2025 for AI bio:
endpoints.news/roche-manifold…
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Manifold Bio retweetledi
Roche has signed a $55 million upfront deal with Manifold Bio, paying to the Boston startup to hunt for better ways of getting drugs into the brain.
endpoints.news/roche-manifold…
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Manifold Bio retweetledi
A Boston biotech has signed a deal with Roche potentially worth over $2 billion to create multiple "shuttles" that can bring drugs for neurological and neurodegenerative diseases across the blood-brain barrier.neurodegenerative diseases. bizjournals.com/boston/news/20…
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Manifold Bio retweetledi
𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐍𝐞𝐰𝐬: @Roche will pay @ManifoldBio $55M up front, and up to $2B in milestones, to collaborate on multiple next-generation brain shuttles for neurological diseases.
Full video: biotechtv.com/post/manifold-…
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