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Driving through Papanasam, Neduntheru, Ayyampettai stretch and seeing no locals for temples like Appakudathaan, Anbil to take care of the temples, we have to realize that it was our immediate previous gen and grandfathers who made the mistake of leaving our ancestral villages. No point blaming others for what we did to ourselves, our temples and our sampradayams. Rushing to Chennai, Bangalore, Delhi Mumbai and abroad for white collar jobs abandoning our temples. It is on us.

I am the VP of Workforce Economics at Oracle. We are worth $420 billion. On Tuesday, we sent 30,000 employees a termination email at 6 AM. Not 9. Not business hours. Six in the morning. They woke up to the word "eliminated." The email came from "Oracle Leadership." Not a manager. Not a name. Oracle Leadership. It said: "We are grateful for your dedication, hard work, and the impact you have made." By the time they read the word "grateful," their access to email, files, and Slack had already been revoked. The gratitude was the last Oracle communication they received. We did not eliminate the roles. We eliminated the salaries. In the same fiscal year, we filed 3,126 H-1B petitions to hire foreign workers. 436 this year alone. The roles are identical. The pay is not. An H-1B software engineer earns $87,000. The domestic median for the same work is $106,000. Eighty-three percent of H-1B workers are classified at entry-level wages for senior positions. The industry calls this a skills gap. It is a pay cut that requires a passport. The visa is tied to the employer. If the worker leaves, they lose their legal right to remain in the country. If they negotiate, they risk the same. If they organize, the sponsor declines to renew. That is retention. Our revenue this quarter is $17.2 billion. Up 22%. Net income up 95%. We have $553 billion in committed future contracts. Up 325%. These are not the numbers of a company that needs to lay anyone off. We took a $2.1 billion restructuring charge. That is the cost of the gratitude. It frees up $8 to $10 billion in annual cash flow. That cash services $156 billion in AI data centers we are building. Starting 2028, OpenAI pays us $82 million per day. Larry Ellison is worth $189 billion. He pledged $51 billion in Oracle shares as collateral for the Stargate AI venture. Announced at the White House. The stock rose 4% on Tuesday. The day of the 6 AM emails. Wall Street did not see 30,000 people. They saw the margin. Amazon laid off 30,000 since October. Filed thousands of H-1B petitions in the same window. This is not one company. This is the operating model. Fire the salary. Keep the role. Fill it with someone whose legal right to remain in the country depends on your continued sponsorship. Pay them less. They will not complain. They cannot. One employee's father worked at Oracle for 20 years. No phone call. No meeting. An email at 6 AM and a locked laptop. The role is still open. The people we fired are free. The people we hired are not.

The cholesterol wars are over. LDL won. New guidelines. Four landmark trials. An oral PCSK9 inhibitor that matches injectables. And data proving we should be treating patients we currently aren't. Here's everything clinicians need to know. 🧵

My aunt passed away a couple days ago. All the important nephews are busy, but the rowdy kids who she loved throughout their retarded periods are trying to get home for her funeral. Something to think about.

#WATCH | Hyderabad, Telangana: Land owner Pallavi Shah says, "I am the owner of 245... We met with Ponguleti Srinivas Reddy... We did not know that they had such an intention... They told us to give them this land, and they will shift us to 244... We said that we do not want any other land... They gave us many offers... They needed that land... They wanted a passage from our land to their plot... At 1 AM, 6 JCBs came and broke our 1 km-long wall... The police were taking a lot of time while writing our complaint... We went to the court and received an interim injunction and police protection... This is ancestral property... They took our workers' phones... They shut our power down."

Presented at #ACC26: Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter. Full Ez-PAVE trial results: nejm.org/doi/full/10.10… Editorial: Paving the Road toward Targeted Lipid Lowering nejm.org/doi/full/10.10… @ACCinTouch

I'm tired of watching people die from preventable heart disease. The cholesterol wars are over. LDL causes atherosclerosis. That's not a pharmaceutical talking point—it's the convergent conclusion of genetics, Mendelian randomization, and 170,000+ patients across 26 randomized trials. Next week, we put diet tribalism and LDL denialism aside and go straight to the science that saves lives. Sign up to receive my newsletter: substance-over-noise.beehiiv.com

LDL isn’t the ambulance, it’s the traffic. When there are too many apoB particles, some get into the wall and stay there—and that’s how the fire starts. Lower the traffic, fewer crashes. That’s not theory, that’s trials, genetics, and pathology all agreeing. - oh, and inflammation can cause the cap of the plaque to rupture, so think of cholesterol as the TNT and inflammation as the fuse. A fuse without cholesterol does nothing.

We should maintain the decorum. Always. And Forever. h/t @PaleBlueTweet Source: youtube.com/watch?v=z1_zou…

@bhava326 Superb

9 months later , 15 kgs lighter.

Your three questions have answers. You just don't like them. 1. Yes. ApoB particles retained in the arterial wall cause atherosclerosis. PCSK9 loss-of-function carriers have lifelong low ApoB and 88% less coronary heart disease. 2. Familial hypercholesterolemia patients have lifelong high ApoB and die of heart attacks in their 30s and 40s. That is not cholesterol causing heart disease. That is ApoB causing heart disease. Yes. The CTT Collaboration: 170,000 patients, 26 trials, 22% reduction in major cardiovascular events per 1 mmol/L LDL-C lowered. FOURIER: 27,564 patients, 20% MACE reduction. ODYSSEY OUTCOMES: 18,924 patients, 15% reduction in major events. Every trial, same direction, dose-response relationship intact. 3. Low cholesterol from statin treatment is not the same as low cholesterol from terminal illness. You are conflating reverse causation with drug effect. Sick people have low cholesterol because disease lowers it. That does not mean lowering cholesterol makes you sick. The word "toxic" requires a risk-benefit calculation. You skipped the benefit half.

@avataram Happy birthday sir

The Indian Government is launching a nationwide Human Papilloma Virus (HPV) vaccination campaign. One of the best decisions from public healthcare perspective. The HPV is responsible for 98% of cervical cancer cases. Cervical cancers are the second most common type of cancer among women in India. Just like Sweden, actively working to eliminate cervical cancer by 2027 through a robust national HPV vaccination program for school-aged children, introduced in 2010 and expanded to boys in 2020. A catch-up programme was launched in 2021, targeting girls born 1994-1999 to bridge the vaccination gap. The program is aimed to prevent HPV-related cancers, including cervical, oropharyngeal, and anal cancers. We should support this campaign because it helps the eliminate a dreadful disease from the future of girls in the country. On the other hand, do not bother about Gayatri here. She is not a doctor. She is a Homeopath. Homeopaths and Chiropractors are among the biggest contributors towards vaccine hesitancy and anti-science sentiments. Because they are pseudoscience peddlers. And when it comes to matters on medical and health, remember this about any Homeopathy practitioner's opinion - they are like farts in the windtunnel. Dispensable, stingy and forgettable.

@bhava326 Ok sir

@Dawktarr Illaainga . I don't work there anymore

@bhava326 sir,what happened to discover alpas?

I can play with statistics too! Over the next 5 years, how much do you think wearing a seatbelt would add to your life expectancy? Mohnot: about 45 seconds Rogan: wow

An experimental arm designed to test reduction in parachute failure rates demonstrates a 90% reduction... but this led to only a 1 second improvement in life! One second!! How worthless!! Disclaimer: we stopped measuring the benefit of the "life saved" once people touch ground (dead or alive). Below is what happens when bad faith actors get their hands on statistics.

Kitna bhi koshish karo. Satya bahar ayega! Here is the video of the incident from another angle! The dog lover, dog feeder comes with the pack of his stray dogs of the society early morning to feed them at illegal dog feeding location - Playground. Suddenly the stray charges towards the old man - who is the Chairman of the society and against whom the dog feeder had grudges. Let me tell you dogs were going towards the feeding location for their morning food but it attacks first. Tell me - isnt this criminal act? In the next version - I will show another angle where you can locate the dog feeder. Question to dog-lover - dog are fed properly, they are sterlised and vaccinated. ABC rules are implemented. Video has been submitted with police @RohanKeluskar @kapsology @BalambalMurali @i_m_harshitsing @Humanetoanimals @deveshtiwaree @SinghDeepakUP

This post did not age well....

For those who give long lectures that feed biscuits to Dogs and they will never bite you. Aunty Jee was a Dog Lover and she was feeding #StrayDogs as a daily routine. But even that did not save her from Dog bite. Now she has to take Rabies Injection.