Edc

@seanluomdphd @MichaelAlbertMD Wow. Sean X. Jumped behind the screen very fast. No questions allowed.

@seanluomdphd @MichaelAlbertMD

The cholesterol wars are over. LDL won. New guidelines. Four landmark trials. An oral PCSK9 inhibitor that matches injectables. And data proving we should be treating patients we currently aren't. Here's everything clinicians need to know. 🧵

@seanluomdphd @MichaelAlbertMD I think the point was that nearly all of the benefit was from revascularization. Anyway, what is the absolute risk reduction for an individual patient? Still 1 to 3%?

@Resign_Grifter @HillValleyForum Lol

@HillValleyForum Yeah, well, when I hear "Texas," I think of tornadoes, floods, a weak power grid, a weak healthcare system, poor education, uncontrolled development, corruption and high property taxes.

"Our head count in Manhattan when I got to JPMorgan was 35,000 and now is 26,000. Our head count in Texas started at 11,000, now it's 33,000. That's what happens." Jamie Dimon on why companies are leaving New York: "Highest individual taxes, highest estate taxes, highest corporate taxes, anti-business sentiment." "When I grew up as a kid in New York City, there were 120 of the Fortune 500 headquarters there. In the 1970s, 60 of the 120 left, including Exxon, GE, IBM, Union Carbide. They're all going to Texas." The Hill & Valley Forum 2026 @HillValleyForum @jpmorgan @ChairmanG

@MichaelAlbertMD So where did most of the observed benefit come from? “Revascularization”—procedures like placing a stent or bypass surgery. In other words, decisions made by clinicians.

2/ Ez-PAVE just answered a question cardiology has avoided for years: Is <55 mg/dL actually BETTER than <70 mg/dL in secondary prevention? 3,048 patients. Head-to-head RCT. The answer: 10 mg/dL difference in achieved LDL → 33% reduction in MACE. NNT ~32 over 3 years. For a target adjustment.

@MichaelAlbertMD There was no statistically significant reduction in cardiovascular death. Non-fatal heart attacks? Less than a 1% absolute benefit. Non-fatal strokes? No significant difference.

@Keir_Starmer "Blah blah, blah bu blah." That's all I heard.

We will be defined by our ability to stand up for British interests in this volatile world. To make our country more secure and resilient. To give working people a fairer deal and deliver more opportunities for their children.

@NickKristof The money would be turned over to corrupt NGO's and the waste would be massive. Lot's of Bentley's and vacation homes with very few dollars reaching the intended recipients. Government ROI has a very low yield.

Imagine if instead of spending $1.3 million/minute on war in Iran, we spent this on people. With 3 days of war, we could eliminate the worst form of global hunger, saving 1.5m kids' lives. With less than 3 weeks worth, we could offer national pre-K or college for all Americans.

@FurkanGozukara Dude. The Russian Chechens couldn't even defeat Ukraine forces. God help them against the most powerful army in the world.

Absolute bombshell. Russian Chechen combat units officially declare they will deploy to Iran to fight alongside Iranian forces if the US launches a ground invasion. They are openly framing it as a holy Jihad against American power. The conflict is expanding globally.

@WallStreetApes A pediatric tonsillectomy (with or without adenoidectomy) in the US typically costs between $2,000 and $7,000 for cash-paying patients, with many procedures averaging around $3,500–$4,500 at surgical centers. Total hospital charges can be much higher, sometimes exceeding $20,000.

This American’s daughter needs a tonsil surgery. The doctor said it would only be about a 20 minute surgery “In case anyone is curious at how f*cked up the United States medical system is, I just got an estimate — estimated cost $108,447.46” Our healthcare system is extortion

@Scott_Wiener LOL WIENER....you said WIENER! A-huh, a-huh, a-huh.

Just the President of the United States threatening to commit war crimes in crystal clear terms

@Maga4liberty Thinking like this is a primary cause of FAFO.

What do you think about taxing billionaires at a higher percentage rate???

@Geniustechw You don't need to wait. We have jobs and better things to do with our time than dancing in frog costumes, spray painting federal buildings and throwing rocks at ICE agents. But, you do you.

This guy has a question for MAGA: “If there are so many of you that support Donald Trump….then why aren’t you guys protesting in support for Trump?”

@joeljackson I'm convinced you can find a study that supports almost anything. Very few people read beyond the press release.

“Statins cause dementia” is one of the dumbest persistent myths in wellness. The evidence does not support it. A massive recent study found statins were associated with a 30% lower risk of Alzheimer’s disease.

@ItsRealJaay @Breaking911 "serving the city" LOL

@Breaking911 This is a huge step forward for NYC workers. Free childcare means parents don’t have to choose between serving the city and raising their families—exactly the kind of support that builds a stronger workforce and community.

NYC Mayor Mamdani announces free childcare center for government workers:"We never want city workers to have to choose between a job that they love and raising their kids in the city they call home."

@hellovask @rushicrypto My dad (born 1916 - not a boomer) bought our family home for $7,200 in 1961. After my mother passed in 2002, the house was sold for $72K. I doubt that we broke even after 40 years of new heating systems, roofs, plumbing repair, new kitchen, new bathroom, etc.

@rushicrypto Boomers who bought their house for half a ham sandwich in 1987 and now have a net worth of 2 million + a pension really can’t afford the $6k a year!!

I’m very confused about the number of people who think “property tax” is a sales tax on you home rather than taxes to pay for public services you use every day. “I paid off my home why do i still pay property taxes?!?!?” Oh, did you also stop using the roads and libraries and sidewalks and parks? Not worried about fires anymore?

@rushicrypto Apparently, they don't teach finance or civics in high school anymore.

@PatrickHarrisSr @PramilaJayapal So build a business and stop growing at $1B because everything over that will be taken from you unless you give it away? You don't understand people, business or government.

@PramilaJayapal Capitated Capitalism puts a limit on greed, and it's economically superior to a direct and immediate wealth tax.

Let me break this down simply: We have a greed problem. We can afford Medicare for All. We can afford to house every person sleeping on the street. We can afford to make public college tuition free and guarantee access to universal pre-k to every child in America. The money exists. It's just sitting in the bank accounts of billionaires who write blank checks to corrupt politicians to make sure it stays there. Tax the rich. Fund the people. That's it.

@DrMauinforma What is the absolute risk reduction? 1.2%? 3.1%?

Can we all just agree that not lowering your high-risk patients’ LDL less than 55 mg/dl is malpractice?

@simonmaechling "Peer reviewed" retractions: The number of retractions has grown from under 1,000 in 2014 to over 10,000 in 2023. Main Causes: The majority of retractions are driven by issues with data integrity, including fake peer reviews, paper mills, and fabricated data.

Doctors have a tremendous capacity to save your life - and one of the most rigorous, evidence-driven systems ever built to reduce harm while doing so. Modern medicine isn’t guesswork. It’s layers of safeguards: •clinical trials •peer review •pharmacovigilance •continuous outcome tracking Mistakes can happen. But the entire system is designed to detect them, learn from them, and reduce them over time. Two centuries ago: •childbirth was deadly •infections were often fatal •surgery meant survival was uncertain Today: •life expectancy has doubled •survival is expected •complications are the exception, not the norm Medicine doesn’t have “little insight.” It has more insight into human biology than at any point in history - and it keeps improving. The real story isn’t harm. It’s how much harm we’ve learned to prevent.