Anthony Leung

Excited to find out that our PARP review has been featured in @MolecularCell's Best of 2023 collection! 🌟 A BIG thank you for the recognition, and a shoutout to former @CbiJhu PhD student @DasovichMorgan! Here's to celebrating the significant strides in our field! 🎉

Flu infection flips a “PAR switch”: instead of hitting new targets, cells lengthen poly(ADP-ribose) (PAR) chains on the same proteins to slow the virus. Flu NS1 suppresses this; PARP1 drives it. ELTA revealed both site & length changes. nam02.safelinks.protection.outlook.com/?url=https%3A%…

We're influiastic about this research from the @LeungLab and Mehle lab! Their @NatureComms paper shows that #InfluenzaA virus infection causes a dramatic upregulation of ADP-ribosylation that as part of the cellular antiviral response. go.nature.com/48JfjXt

@YiliangDing Thanks 😊

Very interesting! Congratulations!

What if RNA had a molecular twin? Our new study w/ the Bedford Lab (MD Anderson) shows poly(ADP-ribose) (PAR) competes with RNA for the same proteins—creating RNA–PAR crosstalk. Unlike RNA, PAR’s info isn’t in sequence but chain length. 🔗 academic.oup.com/nar/article/53… #PARcode

A whirlwind few days in Cancún for the 2nd Spatial Genome Conference 🌊 Great science, great people — and a reminder why we do this. After 20 yrs in nuclear organization, ideas once “unorthodox” (like nuclear actin) are now gaining mainstream. Science moves, and so should we.

Our Spatial Genome Organisation 2025 attendees! Some fantastic presentations, discussions and collaborations have taken place over the past 2 days, with plenty more to come. Its been a pleasure working with Karim, Irene and Matthias on this meeting, looking forward to what the future holds for this brilliant series 🇲🇽 @KarimMekhail @altmeyerlab

Thrilled our PAR-labeling tech supported new @Nature findings from the Gorbunova–Seluanov team! Characterizing CIRBP in bowhead whales reveals how PARP regulation may shape longevity. Kudos to Hongrui & Raymond! 🔗 nature.com/articles/s4158…

Have you already seen this research article, recently published in LSA: PARP10 is Critical for Stress Granule Initiation @LeungLab @JohnsHopkinsSPH @JohnsHopkins @msg2aravinth hubs.la/Q03N47-00"

Join us Oct 23 at 7 PM at @CharlesTheatre for Cracking the Code: Phil Sharp and the Biotech Revolution, narrated by Mark Ruffalo on RNA splicing & biotech’s rise. JHTV Idea Board member Travis McCready is featured! RSVP: buff.ly/8pW8dnt Trailer: buff.ly/TmzpFZq

This study identifies PARP10 as a key regulator of stress granule assembly by ADP-ribosylating G3BP1 and modulating eIF2α phosphorylation and translation factor recruitment @LeungLab @JohnsHopkinsSPH @JohnsHopkins @msg2aravinth life-science-alliance.org/content/8/12/e…

How do our cells build “emergency rooms” when under attack? New paper from our lab out today in Life Science Alliance @LSAjournal : PARP10 acts as the starter pistol for stress granules—tiny hubs that help cells survive stress. Read: life-science-alliance.org/content/8/12/e… #PARP #StressGranules

Venturing beyond lab science at the Bloomberg American Health Summit 2025. Eye-opening conversations on social issues + how we can scale public health innovation to impact millions. Thanks @JOSHSHARFSTEIN for making this possible!

📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots ➡️bit.ly/3JJzYR4

@fried_lab @edward_marcotte Thanks @WatersCorp, @SCIEXnews , Seer, @Avantor_News , @Proteintech for sponsorship!!

What a fantastic day of science at FCBIS! @fried_lab and I had a blast co-organizing this exciting dive into the chemistry-biology interface—great conversations, amazing energy, and a standout keynote by @edward_marcotte. Thanks to all who joined us!

Join an international community of scientists uncovering the roles of nuclear and genome architecture in biology, development, aging, and disease. The 2nd Spatial Genome Organisation Conference is taking place 31 Oct - 03 Nov 2025 in Mexico, chaired by @KarimMekhail , Irene Chiolo & @altmeyerlab 🇲🇽 #SGO25 #FusionGenetics More info here➡️bit.ly/4492G6i

@ZS_biophys This is so cool, Zheng!!

When we added human cytosol extract to the condensate, initially nothing was changing either. But before we got too disappointed, the condensates began to show clear signs of "aging". After 20 hours, all the condensates were "frozen"!

Now published😀 science.org/doi/10.1126/sc…

For #condensate folks 👀 Our study tackles a key gap: how condensate composition is regulated. These p62 bodies require PARP14—but it’s not just presence that matters. It’s PARP14’s enzymatic activity that drives formation. In fact, more PARP14 without activity ≠ condensation.

Why it matters 👇 p62 bodies are key hubs for protein degradation & immune signaling—long linked to cancer & neurodegeneration. Our study shows interferon + PARP14-driven ADP-ribosylation rewires their formation, revealing a new immune-regulated condensate class.

🥳 Out now @embojournal! Interferon induces a new class of p62 bodies, with antiviral & immunotherapy implications. p62 is usually linked to autophagy—but not here. These are driven by PARP14-mediated ADP-ribosylation & rely on ubiquitin-proteasome system. embopress.org/doi/full/10.10…