ObarLab

DEADLINE EXTENDED! ⏰ 🔬Apply to Molecular Mycology: Current Approaches to Fungal Pathogenesis by March 25. Financial aid is available. 🔗More info here: go.mbl.edu/MOMY

Right - and yet the WH is still trying to prevent NIH from sending out funding! This is the best investment we make with public funds! fiercebiotech.com/research/despi…

MCB faculty David Leib and Margie Ackerman (and a team including MCB @DartGRAD alum Chaya Patel & MCB MD/PhD alum Iara Backes) were behind a patent last year, detailing medicines and methods to prevent or treat herpesvirus infections in newborns home.dartmouth.edu/news/2026/03/d…

A dream coming true! IMs and AMs in one paper. With our IM-DTR mice from @gigaipl and SPAM-deleter mice from @bart_lambrecht, @WillingerLab demonstrates that upon niche depletion, monocytes are recruited by fibroblasts in a GPR183-dependent manner before differentiating into macs

🤩 MCB Faculty Soni @LacefieldLab @DartmouthBCB was honored with the Ira Herskowitz Award from @GeneticsGSA! This prestigious award recognizes “outstanding contributions in the field of yeast research in the last 20 years” Kudos! genetics-gsa.org/yeast-2026/inv…

GRC Fungal Cell and Molecular Biology!! Delighted to publish the full line-up for this 50th Anniversary GRC. Discounted GRC registration for GRS attendees (selected from abstracts). Limited places available. 2026 Cellular and Molecular Fungal Biology Conference GRC.

By screening viral proteins’ effects on human cells, researchers in Science discover that immune cells can detect infections not only by recognizing pathogens directly, but also by sensing the damage caused by viral attack. The findings show that this plant-like immune defense strategy—known as effector-triggered immunity—also operates in mammals. scim.ag/46gJrrH

Myeloid core of TB granulomas is partitioned into two distinct metabolic environments, one of which is hypoxic & associated with pathological immune cell states that subvert immunity to TB @NatImmunol @Stanford @NIAIDNews @MikeAngeloLab nature.com/articles/s4159…

Open Access: Selective Targeting of IL-1RAP-Dependent Eosinophilic Inflammation in Allergic Fungal Airway Disease. Thomas J. Williams, Darius Armstrong-James Read the article here: doi.org/10.1111/all.70… In a mouse model of fungal allergic airway disease, Williams et al. demonstrate the role of IL-1RAP in driving type 2 inflammation. IL1RAP-deficient mice exhibited a significant reduction in eosinophilia during chronic exposure to Aspergillus fumigatus compared to controls. #Allergy_journal Read more articles published in #Allergy on allergic #asthma here: journalallergy.com/Asthma-Lower-A…

'Universal' intranasal liposomal vaccine combining antigen with TLR4/7/8 provided broad, durable protection in mice vs coronaviruses and bacteria via memory T cells and imprinted alveolar macrophages science.org/doi/10.1126/sc… @ScienceMagazine #Pulendran @Stanford

GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function @JCI_insight @gottschalk_lab insight.jci.org/articles/view/…

Synergistic activation of TLR2 and Dectin-2 by mannose-capped lipoarabinomannan reprograms macrophage lipid metabolism in tuberculosis biorxiv.org/content/10.648… #biorxiv_micrbio

In vivo experimental model of β-glucan-induced innate immune memory biorxiv.org/content/10.648… #biorxiv_immuno

Excessive #inflammation? We uncover @immunity that #IFN‑I via #ISG15 in #macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self‑limits #ISG amplification: a built‑in brake that promotes resolution. Open-access: sciencedirect.com/science/articl…

Why are pDCs so good at producing type I interferons? We set out to address this long unanswered question in our recent @ImmunityCP study. Again a great collaboration between the Reizis Lab @nyugrossman @UChicago and @agalitzina @leonidmirny @MIT cell.com/immunity/fullt… 1/

Macrophage adaptation to hypoxia in the tuberculous granuloma potentiates mycobacterium-induced mitochondrial damage and granuloma ... biorxiv.org/content/10.648… #biorxiv_micrbio

The landscape of regulated cell death: It’s all downhill from here dlvr.it/TQn53z

🥳🍾Some good afternoon news on our R01 proposal. Now for the fun part — to actually get to do the science and experiments!!

@DaneParkerLab Congratulations Dane!

Persistence pays off!! Taken 10 years since its predecessor!! Don’t give up folks!

Latest research from the lab where we took a deep dive into organ specific immune responses and how these are affected by fungal strain variation. Now online from @JournalSpectrum journals.asm.org/doi/10.1128/sp…